DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpy and Mag

DIOPT Version :9

Sequence 1:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster
Sequence 2:	NP_001333013.1	Gene:	Mag / 17136	MGIID:	96912	Length:	627	Species:	Mus musculus

Alignment Length:	435	Identity:	91/435 - (20%)
Similarity:	144/435 - (33%)	Gaps:	106/435 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly  6190 TTRPFEASTPSPASLETTVPSVTSETTTNVPI--GSTGGQVTGQTTAPP---SEVRTTIGVEEST 6249
            ||..||..    |||:...|.|..|..::|..  ||....:.|..:.||   :.:|..:.:.|:.
Mouse   224 TTLQFEGY----ASLDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGMVLREAV 284

  Fly  6250 LPSRSTD--RTSPSESPETPTTLPSDFITRPHSEQT-TESTRDVPTTRPFEASTPSPASLKTTVP 6311
            ..|...|  ..:|.|          |.:....:|.. .:..|.|..:..:   .|...::..||.
Mouse   285 AKSLYLDLEEVTPGE----------DGVYACLAENAYGQDNRTVELSVMY---APWKPTVNGTVV 336

  Fly  6312 SVTSEATTNVPIGSTGGQVTEQTTSSPSEVRTTIR--------VEESTLPSRSTDRTTPSESPE- 6367
            :|..|..:          :...|.|:|..:.|..:        :.||.| .......||.:..|
Mouse   337 AVEGETVS----------ILCSTQSNPDPILTIFKEKQILATVIYESQL-QLELPAVTPEDDGEY 390

  Fly  6368 ------------TPTTLPSDFTTRPHSEKTTESTRDVPTTRPFETSTPSPASLETTVPS--VTL- 6417
                        |...|..:|......|....:.||.........|.|.| |:...:||  ||:
Mouse   391 WCVAENQYGQRATAFNLSVEFAPIILLESHCAAARDTVQCLCVVKSNPEP-SVAFELPSRNVTVN 454

  Fly  6418 ETTTSVPMGSTGG-------QVTGQTTAPPSEV---RTTIRVEESTLPSRSTDRTSPSESPETPT 6472
            ||..........|       .:.||..|||..:   |.....:...||.:...|...::......
Mouse   455 ETEREFVYSERSGLLLTSILTIRGQAQAPPRVICTSRNLYGTQSLELPFQGAHRLMWAKIGPVGA 519

  Fly  6473 TLPSD-------FITRPHSEK-TTESTRDVPTTRPFEASTPSSASSGNNCSISY---FR-----N 6521
            .:...       :||:...:| .|||               ||.|.|:|..:.|   ||     :
Mouse   520 VVAFAILIAIVCYITQTRRKKNVTES---------------SSFSGGDNPHVLYSPEFRISGAPD 569

  Fly  6522 HYKCSNRFNRSADRTTPSESPETPTLPSDFTTRPHSEQTTESTRD 6566
            .|: |.:....::|.......|:|.|...::   ||:.....|:|
Mouse   570 KYE-SEKQRLGSERRLLGLRGESPELDLSYS---HSDLGKRPTKD 610

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpy	NP_001260032.1	EGF_3	137..166	CDD:289699
		EGF_CA	212..247	CDD:238011
		EGF_CA	255..>286	CDD:214542
		EGF_CA	298..331	CDD:238011
		EGF_CA	338..373	CDD:238011
		EGF_CA	413..456	CDD:238011
		EGF_CA	457..490	CDD:238011
		EGF_CA	497..>529	CDD:214542
		EGF_CA	580..>612	CDD:214542
		EGF_3	676..702	CDD:289699
		EGF_CA	1022..1056	CDD:214542
		EGF_CA	2227..2260	CDD:238011
		EGF_CA	2393..>2422	CDD:214542
		DUF4758	4088..4282	CDD:292572
		DUF4696	4127..4678	CDD:292395
		DUF4758	4275..4448	CDD:292572
		DUF4758	4377..4574	CDD:292572
		DUF4758	4581..4754	CDD:292572
		DUF4758	4683..4847	CDD:292572
		DUF4758	4785..4964	CDD:292572
		DUF4696	4841..5385	CDD:292395
		DUF4758	4887..5098	CDD:292572
		DUF4758	5193..5371	CDD:292572
		DUF4758	5294..5487	CDD:292572
		DUF4758	5445..5650	CDD:292572
		DUF4758	5700..5877	CDD:292572
		DUF4696	5756..6396	CDD:292395	47/234 (20%)
		DUF4758	5802..5979	CDD:292572
		DUF4758	5964..6171	CDD:292572
		DUF4758	6181..6360	CDD:292572	38/185 (21%)
		DUF4696	6339..6999	CDD:292395	57/278 (21%)
		DUF4758	6662..6839	CDD:292572
		DUF4758	6764..6941	CDD:292572
		DUF4758	6866..7045	CDD:292572
		DUF4758	6968..7179	CDD:292572
		DUF4696	7024..7569	CDD:292395
		DUF4758	7172..7383	CDD:292572
		DUF4696	7330..7964	CDD:292395
		DUF4758	7400..7587	CDD:292572
		DUF4758	7538..7707	CDD:292572
		DUF4758	7798..7979	CDD:292572
		DUF4758	7946..8126	CDD:292572
		YppG	18767..>18832	CDD:290883
		Med25_SD1	18795..18955	CDD:288132
		MISS	19026..19258	CDD:292450
		ZP	22576..22811	CDD:214579
		Zona_pellucida	<22714..22810	CDD:278526
Mag	NP_001333013.1	Interaction with RTN4R and RTN4RL2. /evidence=ECO:0000250\|UniProtKB:P07722	20..325		26/117 (22%)
		IgV_CD33	22..137	CDD:409377
		Ig strand B	38..42	CDD:409377
		Ig strand C	56..60	CDD:409377
		Ganglioside GT1b binding. /evidence=ECO:0000269\|PubMed:27922006	65..67
		Ig strand E	100..104	CDD:409377
		Ig strand F	114..119	CDD:409377
		Ganglioside GT1b binding. /evidence=ECO:0000269\|PubMed:27922006	124..128
		Ig strand G	128..133	CDD:409377
		IgC2_CD33_d2_like	141..235	CDD:409579	6/14 (43%)
		Ig strand B	155..159	CDD:409579
		Ig strand C	171..175	CDD:409579
		Ig strand E	200..204	CDD:409579
		Ig strand F	214..219	CDD:409579
		Ig strand G	229..232	CDD:409579	1/6 (17%)
		Ig_3	239..309	CDD:404760	16/79 (20%)
		Ig strand A	239..242	CDD:409353	1/2 (50%)
		Ig strand A'	248..251	CDD:409353	1/2 (50%)
		Ig strand B	256..264	CDD:409353	1/7 (14%)
		Ig strand C	270..274	CDD:409353	0/3 (0%)
		Ig strand C'	277..280	CDD:409353	0/2 (0%)
		Ig strand E	289..293	CDD:409353	1/3 (33%)
		Ig strand F	301..309	CDD:409353	0/7 (0%)
		Ig strand G	312..322	CDD:409353	2/9 (22%)
		IG	333..409	CDD:214652	16/86 (19%)
		Required for normal axon myelination in the central nervous system. /evidence=ECO:0000269\|PubMed:9482783	578..627		8/36 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4475
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900