DRSC/TRiP Functional Genomics Resources

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Protein Alignment dpy and Ltbp2

DIOPT Version :9

Sequence 1:NP_001260032.1 Gene:dpy / 318824 FlyBaseID:FBgn0053196 Length:22949 Species:Drosophila melanogaster
Sequence 2:NP_001357672.1 Gene:Ltbp2 / 16997 MGIID:99502 Length:1809 Species:Mus musculus


Alignment Length:1130 Identity:336/1130 - (29%)
Similarity:458/1130 - (40%) Gaps:303/1130 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    80 CFLGADELSKELKCTNDCDKDGTKCTHGACL---NGV-CHCNDGY------GGCNCVDKDENECK 134
            ||.||..:                |..|.|:   ||. |.|:.||      ..|.    |:|||.
Mouse   836 CFAGASNI----------------CGPGTCVSLPNGYRCVCSPGYQLHPSQDYCT----DDNECM 880

  Fly   135 QRPCDVFAHCTNTLGSFTCTCFPGYR----GNGFHCEDIDECQDPAIAARCVENAECCNLPAHFL 195
            :.||:....|.|::||::|.|:|||.    .:...|:|||||:.|.:.:    ...|.|....:.
Mouse   881 RNPCEGRGRCVNSVGSYSCLCYPGYTLVTLRDTQECQDIDECEQPGVCS----GGRCSNTEGSYH 941

  Fly   196 CKCKDGYEGDGEVLCTDVDECRNPENCGPNALCTNTPGNYTC-SCPDGYVGNNPYREGCQDVDEC 259
            |:|..||....:..|.|::|||:|..| |:..|.|:||:||| :|.:||||.:   ..|.||:||
Mouse   942 CECDRGYIMVRKGHCQDINECRHPGTC-PDGRCVNSPGSYTCLACEEGYVGQS---GSCVDVNEC 1002

  Fly   260 SYPNVCGPGAICTNLEGSYRCDCPPGYDGDGRSESGCVDQDECA-RTPCGRNADCLNTDGSFRC- 322
            ..|.:|..|. |.|:|||:||.|.|||:.. ..:.||.|.|||| |..|.... ||||:|||.| 
Mouse  1003 LTPGICTHGR-CINMEGSFRCSCEPGYEVT-PDKKGCRDVDECASRASCPTGL-CLNTEGSFTCS 1064

  Fly   323 LCPDGY-SGDPMNGCEDVDECATNNPCGLGAECVNLGGSFQCR-CPSGFVLEHDPHADQLPQPLN 385
            .|..|| ..:....|||:||||....|..|. |.|..|||.|: |..|:          .|.|| 
Mouse  1065 ACQSGYWVNEDGTACEDLDECAFPGVCPTGV-CTNTVGSFSCKDCDRGY----------RPNPL- 1117

  Fly   386 TQQLGYGPGATDIAPYQRTSGAGLACLDIDECNQPDGVAKCGTNAKCINFPGSYRCLCPSGFQGQ 450
                                  |..|.|:|||..|....:.|   :|.|..|||:|||..|||..
Mouse  1118 ----------------------GNRCEDVDECEGPQSSCRGG---ECKNTEGSYQCLCHQGFQLV 1157

  Fly   451 GYLHCENINEC-QDNPCGENAICTDTVGSFVCTCKPDY-TGDPFRGCVDIDECTALDKPC-GQHA 512
            ....||::||| .:..|..:..|.:::|||.|.|.|.: :.:....|.|:|||.|.| || |.| 
Mouse  1158 NGTMCEDVNECVGEEHCAPHGECLNSLGSFFCLCAPGFASAEGGTRCQDVDECAATD-PCPGGH- 1220

  Fly   513 VCENTVPGYNCKCPQGYDGKPDPKVACEQVDVNILCSSNFDCTNNAECIENQCFCLDGFEPIGSS 577
             |.||...::|.|..|:...||                                        ...
Mouse  1221 -CVNTEGSFSCLCETGFQPSPD----------------------------------------SGE 1244

  Fly   578 CVDIDECRTHAE-VCGPHAQCLNTPGSYGC--ECEAGYVGSPPRMACKQPCEDVR-------CGA 632
            |:|||||....: |||.. :|.|:||||.|  :|:.|:..:|     ...|.|:.       ||.
Mouse  1245 CLDIDECEDREDPVCGAW-RCENSPGSYRCILDCQPGFYVAP-----NGDCIDIDECANDTVCGN 1303

  Fly   633 HAYCKPDQNEAYCVCEDGWTYNPSDVAAGCVDIDECDVMHGPFGSCGQNATCTNSAGGFTCACPP 697
            |.:|........|:|:.|:..:||  ...|||::||::|   ...|| :|.|.|..|.|.|.|  
Mouse  1304 HGFCDNTDGSFRCLCDQGFETSPS--GWECVDVNECELM---MAVCG-DALCENVEGSFLCLC-- 1360

  Fly   698 GFSGDPHSKCVDVDECRTGASKCGAGA------------------ECVNVPGGGYTCRCPGNTIA 744
              :.|......:...||...    |||                  ||.:...||..|   ...:.
Mouse  1361 --ASDLEEYDAEEGHCRPRV----AGAQRIPEVRTEDQAPSLIRMECYSEHNGGPPC---SQILG 1416

  Fly   745 DPDPSVRCVPIVSCS-------ANEDCPGNSICDATKRCLCPEPNIGNDCRHPCE---------- 792
            .......|    .|:       |...||.....:.::.|...:..|      |.|          
Mouse  1417 QNSTQAEC----CCTQGARWGKACAPCPSEDSVEFSQLCPSGQGYI------PVEGAWTFGQTMY 1471

  Fly   793 --ALNCGAHAQCMLANGQAQ-------CLCAPGYTGNSALAGGCNDIDECRANPCAEKAICSNTA 848
              |..|......:..||:..       |||.||| ...|.:..|.|.:||:...| |...|.||.
Mouse  1472 TDADECVLFGPALCQNGRCLNIVPGYICLCNPGY-HYDASSRKCQDHNECQDLAC-ENGECVNTE 1534

  Fly   849 GGYLCQCPGGSSGDPYREGCI--TSKTVGCSD----ANPC---ATGETCVQ---DSYTGNSVCIC 901
            |.:.|.|....:.|...:.|:  ||.|....|    .:.|   .|.:.|.|   ..:|..:.|.|
Mouse  1535 GSFHCLCNPPLTLDLSGQRCVNSTSSTEDFPDHDIHMDICWKKVTNDVCSQPLRGHHTTYTECCC 1599

  Fly   902 RQGY----------ERNSE-NGQCQDVDECSVQRG-----KPAC----GLNALCKNLPG------ 940
            :.|.          .|:|| ..|..:|.....:||     :|..    ||:.|.:||.|      
Mouse  1600 QDGEAWSQQCALCPPRSSEVYAQLCNVARIEAERGAGIHFRPGYEYGPGLDDLPENLYGPDGAPF 1664

  Fly   941 -SY---ECRCPQGHNGNPFIMCEICNTP---------ECQCQSPYKLVGNS-------------C 979
             :|   |...|:....||... ...|||         |.|   |:.|..:|             |
Mouse  1665 YNYLGPEDTAPEPPFSNPASQ-PGDNTPVLEPPLQPSELQ---PHYLASHSEPLASFEGLQAEEC 1725

  Fly   980 -VLSGCSSGQACPSGAECISIAGGVSYCACPKGYQTQ-PDGSCVDVDECEERG--AQLCAFGAQC 1040
             :|:||.:|:       |:.:..|.: |.|.:|:|.. ...:||||:|||:..  |.|||.| .|
Mouse  1726 GILNGCENGR-------CVRVREGYT-CDCFEGFQLDAAHMACVDVNECEDLNGPAALCAHG-HC 1781

  Fly  1041 VNKPGSYSCHCPEGYQGDAYNGLCA 1065
            .|..|||.|||..||..:.....||
Mouse  1782 ENTEGSYRCHCSPGYVAEPGPPHCA 1806

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dpyNP_001260032.1 EGF_3 137..166 CDD:289699 11/32 (34%)
EGF_CA 212..247 CDD:238011 19/35 (54%)
EGF_CA 255..>286 CDD:214542 16/30 (53%)
EGF_CA 298..331 CDD:238011 18/35 (51%)
EGF_CA 338..373 CDD:238011 15/35 (43%)
EGF_CA 413..456 CDD:238011 17/42 (40%)
EGF_CA 457..490 CDD:238011 11/34 (32%)
EGF_CA 497..>529 CDD:214542 15/32 (47%)
EGF_CA 580..>612 CDD:214542 16/34 (47%)
EGF_3 676..702 CDD:289699 9/25 (36%)
EGF_CA 1022..1056 CDD:214542 19/35 (54%)
EGF_CA 2227..2260 CDD:238011
EGF_CA 2393..>2422 CDD:214542
DUF4758 4088..4282 CDD:292572
DUF4696 4127..4678 CDD:292395
DUF4758 4275..4448 CDD:292572
DUF4758 4377..4574 CDD:292572
DUF4758 4581..4754 CDD:292572
DUF4758 4683..4847 CDD:292572
DUF4758 4785..4964 CDD:292572
DUF4696 4841..5385 CDD:292395
DUF4758 4887..5098 CDD:292572
DUF4758 5193..5371 CDD:292572
DUF4758 5294..5487 CDD:292572
DUF4758 5445..5650 CDD:292572
DUF4758 5700..5877 CDD:292572
DUF4696 5756..6396 CDD:292395
DUF4758 5802..5979 CDD:292572
DUF4758 5964..6171 CDD:292572
DUF4758 6181..6360 CDD:292572
DUF4696 6339..6999 CDD:292395
DUF4758 6662..6839 CDD:292572
DUF4758 6764..6941 CDD:292572
DUF4758 6866..7045 CDD:292572
DUF4758 6968..7179 CDD:292572
DUF4696 7024..7569 CDD:292395
DUF4758 7172..7383 CDD:292572
DUF4696 7330..7964 CDD:292395
DUF4758 7400..7587 CDD:292572
DUF4758 7538..7707 CDD:292572
DUF4758 7798..7979 CDD:292572
DUF4758 7946..8126 CDD:292572
YppG 18767..>18832 CDD:290883
Med25_SD1 18795..18955 CDD:288132
MISS 19026..19258 CDD:292450
ZP 22576..22811 CDD:214579
Zona_pellucida <22714..22810 CDD:278526
Ltbp2NP_001357672.1 Glutenin_hmw <72..>170 CDD:281191
Heparin-binding. /evidence=ECO:0000250 94..115
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 103..152
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 220..305
Heparin-binding. /evidence=ECO:0000250 226..243
Heparin-binding. /evidence=ECO:0000250 329..339
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 492..524
TB 547..>580 CDD:334208
EGF_CA 606..>635 CDD:214542
TB 667..709 CDD:334208
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 727..758
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 784..816
EGF_CA 875..909 CDD:238011 15/33 (45%)
EGF_CA 918..>948 CDD:214542 10/33 (30%)
EGF_CA 958..993 CDD:238011 19/35 (54%)
EGF_CA 998..1029 CDD:214542 17/31 (55%)
EGF_CA 1039..1079 CDD:311536 18/40 (45%)
EGF_CA 1081..1121 CDD:311536 19/73 (26%)
EGF_CA 1123..1163 CDD:214542 17/42 (40%)
EGF_CA 1164..1205 CDD:214542 11/40 (28%)
EGF_CA 1206..1245 CDD:311536 18/81 (22%)
EGF_CA 1291..1324 CDD:214542 8/32 (25%)
TB 1411..1452 CDD:334208 6/47 (13%)
EGF_CA 1473..1506 CDD:214542 10/33 (30%)
TB 1583..1625 CDD:334208 10/41 (24%)
C-terminal domain. /evidence=ECO:0000250|UniProtKB:Q14767 1627..1809 57/193 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1667..1713 13/49 (27%)
EGF_CA 1762..>1796 CDD:214542 18/34 (53%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 50 1.000 Domainoid score I11570
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D4721at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm43451
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
33.010

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