DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpy and Krt18

DIOPT Version :9

Sequence 1:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster
Sequence 2:	NP_034794.2	Gene:	Krt18 / 16668	MGIID:	96692	Length:	423	Species:	Mus musculus

Alignment Length:	427	Identity:	82/427 - (19%)
Similarity:	132/427 - (30%)	Gaps:	142/427 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly  7789 FTTRPHSEQTTEST--RDVPTTRPFEASTPS----PASLETTV--------------PSVTSETT 7833
            ||||    .||.||  |.:.:.|     |||    |||...:|              .||...:.
Mouse     3 FTTR----STTFSTNYRSLGSVR-----TPSQRVRPASSAASVYAGAGGSGSRISVSRSVWGGSV 58

  Fly  7834 TNVPIGSTGGQLTEQSTSSPSEVR--------TTIRVEESTLPSRSTD----------------- 7873
            .:..:...||..||:.|......|        .::..|...|.|:..:
Mouse    59 GSAGLAGMGGIQTEKETMQDLNDRLASYLDKVKSLETENRRLESKIREHLEKKGPQGVRDWGHYF 123

  Fly  7874 --------RTFPSESPEKPTTLPSD------------FTTRPHLEQTTESTRDVLTTRPFETSTP 7918
                    :.|.:........|..|            :.|...:.|:.||  |:...|.....|.
Mouse   124 KIIEDLRAQIFANSVDNARIVLQIDNARLAADDFRVKYETELAMRQSVES--DIHGLRKVVDDTN 186

  Fly  7919 -SPVSLETTVPSVTSE------------TSTNVPIGSTGGQVTEQTTAPPSVRTTETI--VKSTH 7968
             :.:.|||.:.::..|            ......|.|:|  :|.:..||.|...::.:  :::.:
Mouse   187 ITRLQLETEIEALKEELLFMKKNHEEEVQGLEAQIASSG--LTVEVDAPKSQDLSKIMADIRAQY 249

  Fly  7969 PAVSPDTTIPSEIPATRVPLESTTRLYTDQTIPPGSTDRTT-SSERPDESTRLTSEESTETTRPV 8032
            .|::         ...|..|:.    |..|.|...:|..|| |:|..|..|.||....|..|..:
Mouse   250 EALA---------QKNREELDK----YWSQQIEESTTVVTTKSAEIRDAETTLTELRRTLQTLEI 301

  Fly  8033 PTVSPR---------------------DALETTVTSLITETTKTTSGGTPRGQVTER----TTKS 8072
            ...|.:                     :.|...:..|.:|..:|.:.|..:.|..|.    ..|.
Mouse   302 DLDSMKNQNINLENSLGDVEARYKAQMEQLNGVLLHLESELAQTRAEGQRQAQEYEALLNIKVKL 366

  Fly  8073 VSELTTGRS----------SDVVTERTMPSNISSTTT 8099
            .:|:.|.|.          :|.:........:..|||
Mouse   367 EAEIATYRRLLEDGEDFSLNDALDSSNSMQTVQKTTT 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpy	NP_001260032.1	EGF_3	137..166	CDD:289699
		EGF_CA	212..247	CDD:238011
		EGF_CA	255..>286	CDD:214542
		EGF_CA	298..331	CDD:238011
		EGF_CA	338..373	CDD:238011
		EGF_CA	413..456	CDD:238011
		EGF_CA	457..490	CDD:238011
		EGF_CA	497..>529	CDD:214542
		EGF_CA	580..>612	CDD:214542
		EGF_3	676..702	CDD:289699
		EGF_CA	1022..1056	CDD:214542
		EGF_CA	2227..2260	CDD:238011
		EGF_CA	2393..>2422	CDD:214542
		DUF4758	4088..4282	CDD:292572
		DUF4696	4127..4678	CDD:292395
		DUF4758	4275..4448	CDD:292572
		DUF4758	4377..4574	CDD:292572
		DUF4758	4581..4754	CDD:292572
		DUF4758	4683..4847	CDD:292572
		DUF4758	4785..4964	CDD:292572
		DUF4696	4841..5385	CDD:292395
		DUF4758	4887..5098	CDD:292572
		DUF4758	5193..5371	CDD:292572
		DUF4758	5294..5487	CDD:292572
		DUF4758	5445..5650	CDD:292572
		DUF4758	5700..5877	CDD:292572
		DUF4696	5756..6396	CDD:292395
		DUF4758	5802..5979	CDD:292572
		DUF4758	5964..6171	CDD:292572
		DUF4758	6181..6360	CDD:292572
		DUF4696	6339..6999	CDD:292395
		DUF4758	6662..6839	CDD:292572
		DUF4758	6764..6941	CDD:292572
		DUF4758	6866..7045	CDD:292572
		DUF4758	6968..7179	CDD:292572
		DUF4696	7024..7569	CDD:292395
		DUF4758	7172..7383	CDD:292572
		DUF4696	7330..7964	CDD:292395	49/254 (19%)
		DUF4758	7400..7587	CDD:292572
		DUF4758	7538..7707	CDD:292572
		DUF4758	7798..7979	CDD:292572	46/260 (18%)
		DUF4758	7946..8126	CDD:292572	37/192 (19%)
		YppG	18767..>18832	CDD:290883
		Med25_SD1	18795..18955	CDD:288132
		MISS	19026..19258	CDD:292450
		ZP	22576..22811	CDD:214579
		Zona_pellucida	<22714..22810	CDD:278526
Krt18	NP_034794.2	Head	2..71		21/76 (28%)
		Necessary for interaction with PNN. /evidence=ECO:0000250	62..366		55/320 (17%)
		Interaction with TRADD. /evidence=ECO:0000250	69..121		7/51 (14%)
		Filament	72..383	CDD:306535	56/327 (17%)
		Coil 1A	72..107		6/34 (18%)
		Linker 1	108..125		0/16 (0%)
		Coil 1B	126..217		14/92 (15%)
		Linker 12	218..241		7/24 (29%)
		Interaction with DNAJB6. /evidence=ECO:0000250	236..384		29/160 (18%)
		Coil 2	242..380		29/150 (19%)
		Tail	381..423		4/23 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910