DRSC/TRiP Functional Genomics Resources

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Protein Alignment dpy and Fbn2

DIOPT Version :9

Sequence 1:NP_001260032.1 Gene:dpy / 318824 FlyBaseID:FBgn0053196 Length:22949 Species:Drosophila melanogaster
Sequence 2:NP_034311.2 Gene:Fbn2 / 14119 MGIID:95490 Length:2907 Species:Mus musculus


Alignment Length:3223 Identity:796/3223 - (24%)
Similarity:1091/3223 - (33%) Gaps:1146/3223 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    26 QPQPFKTNLRANSRFRGEVFYLNLENGYFGCQ-VNESTEYLQLFNLSKLCDGTQ----------D 79
            ||||.:         ||  |..|:..|  .|| |:|...      :..||.|..          .
Mouse   257 QPQPCR---------RG--FIPNIRTG--ACQDVDECQA------IPGLCQGGNCINTVGSFECR 302

  Fly    80 CFLGADELSKELKC--TNDCDKDGTKCTHGACLNGV----CHCNDGY----GGCNCVDKDENECK 134
            |..|..:.....||  .::|......|..|.|.|.|    |.|..|:    .|..|:|:....| 
Mouse   303 CPAGHKQSETTQKCEDIDECSVIPGVCETGDCSNTVGSYFCLCPRGFVTSTDGSRCIDQRAGTC- 366

  Fly   135 QRPCDVFAHCTN---------TLGSFTCTCFPG-------------------YR----------- 160
                  |:...|         .:....|.|.||                   ||           
Mouse   367 ------FSGLVNGRCAQELPGRMAKAQCCCEPGRCWSIGTIPEACPVRGSEEYRRLCLDGLPMGG 425

  Fly   161 ---------------GNGFH---------------------------------------CEDIDE 171
                           |||:.                                       .:.||.
Mouse   426 IPGSSVSRPGGTGSTGNGYGPGGTGFLPIPGDNGFSPGVGGAGVGAGGQGPIITGLTILNQTIDI 490

  Fly   172 CQDPAIAARCVENAECCNLPAHFLCKCKDGYEGDGEVLCTDVDEC-RNPENCGPNALCTNTPGNY 235
            |:..  |..|: |..|....:.:.|:|..||:.|....|.||||| .||  |. |..|.||||:|
Mouse   491 CKHH--ANLCL-NGRCIPTVSSYRCECNMGYKQDANGDCIDVDECTSNP--CS-NGDCVNTPGSY 549

  Fly   236 TCSCPDGYVGNNPYREGCQDVDECSYPNVCGPGAICTNLEGSYRCDCPPGYD--GDGRSESGCVD 298
            .|.|..|: ...|.::.|.|:|||....|......|.|.:||::|.|..|::  .||::   |||
Mouse   550 YCKCHAGF-QRTPTKQACIDIDECIQNGVLCKNGRCVNTDGSFQCICNAGFELTTDGKN---CVD 610

  Fly   299 QDECARTPCGRNADCLNTDGSFRCLCPDGYSGDPMNG--CEDVDECATNNPCGLGAECVNLGGSF 361
            .|||..|....|..|:|.||||:|:|..|:...| ||  |.|||||.|...| :...|:|..|||
Mouse   611 HDECTTTNMCLNGMCINEDGSFKCVCKPGFILAP-NGRYCTDVDECQTPGIC-MNGHCINNEGSF 673

  Fly   362 QCRCPSGFVLEHDPHADQLPQPLNTQQLGYG-----------PGATDIA-------------PYQ 402
            :|.||.|..:..|   .::....:.:...||           |||...:             |.|
Mouse   674 RCDCPPGLAVGVD---GRVCVDTHMRSTCYGEIKKGVCVRPFPGAVTKSECCCANPDYGFGEPCQ 735

  Fly   403 R-------------TSGAGLAC--LDIDECN-QPDGVAKCGTNAKCINFPGSYRCLCPSGFQ--- 448
            .             :||.|:..  .||:||. .||..|    |..|.|..|||||.|.||::   
Mouse   736 PCPAKNSAEFHGLCSSGIGITVDGRDINECALDPDICA----NGICENLRGSYRCNCNSGYEPDA 796

  Fly   449 -GQGYLHCENINECQDNP--CGENAICTDTVGSFVCTCKPDYTGDPFR----GCVDIDECTALDK 506
             |:   :|.:|:||..|.  | :|.:|.:|.||:.|||.|.|.   ||    .|.|::||.:  .
Mouse   797 SGR---NCIDIDECLVNRLLC-DNGLCRNTPGSYSCTCPPGYV---FRTETETCEDVNECES--N 852

  Fly   507 PCGQHAVCENTVPGYNCKCPQGYDGKPDPKVACEQVD----VNI---LCSSNFD-CTNNAEC--- 560
            || .:..|.|.:..::|:|..|........:..:.:.    :||   .|..|.: .|..:||   
Mouse   853 PC-VNGACRNNLGSFHCECSPGSKLSSTGLICIDSLKGTCWLNIQDNRCEVNINGATLKSECCAT 916

  Fly   561 -----------IENQCFCLDGFEPI-GSSCVDIDECRTHAEVCGPHAQCLNTPGSYGCECEAGYV 613
                       .|....|..||..| |.:|.|::||.....|| |:.:|:|:.||:.|||..|..
Mouse   917 LGAAWGSPCERCELDAACPRGFARIKGVTCEDVNECEVFPGVC-PNGRCVNSKGSFHCECPEGLT 980

  Fly   614 --GSPPRMACKQPCEDVRCGAHAYCKPDQNEAY-----------CVCEDGWTY------------ 653
              |:      .:.|.|:|. .|.:.|.|::|..           |.|..|..:            
Mouse   981 LDGT------GRVCLDIRM-EHCFLKWDEDECIHPVPGKFRMDACCCAVGAAWGTECEECPKPGT 1038

  Fly   654 --------------NPSDVAAG---CVDIDECDVMHG--PFGSCGQNATCTNSAGGFTCACPPGF 699
                          |..|:..|   ..||:||....|  .:|.      |.|:.|.|.|.|..||
Mouse  1039 KEYETLCPRGPGFANRGDILTGRPFYKDINECKAFPGMCTYGK------CRNTIGSFKCRCNNGF 1097

  Fly   700 SGDPHSK-CVDVDECRTGASKCGAGAECVNVPGGGYTCRCPGNTIADPDPSVRCVPIVSCSANED 763
            :.|...: |.|:||||.....||:|. |||.|                                 
Mouse  1098 ALDMEERNCTDIDECRISPDLCGSGI-CVNTP--------------------------------- 1128

  Fly   764 CPGNSICDATKRCLCPEPNIGNDCRHPCEALNCGAHAQCMLANGQAQCLCAPGYTGNSALAGGCN 828
                                                       |..:|.|..||.....:...|.
Mouse  1129 -------------------------------------------GSFECECFEGYESGFMMMKNCM 1150

  Fly   829 DIDECRANP-CAEKAICSNTAGGYLCQCPGGSSGDPYREGCITSKTVGCSDANPCATGETCVQDS 892
            |||||..|| ......|.||.|.:.|.||.|....|.||.|:.......|| |.|..|: ||  :
Mouse  1151 DIDECERNPLLCRGGTCVNTEGSFQCDCPLGHELSPSREDCVDINECSLSD-NLCRNGK-CV--N 1211

  Fly   893 YTGNSVCICRQGYERNSENGQCQDVDECSVQRGKPACGLNALCKNLPGSYECRCPQGHNGNPFIM 957
            ..|...|.|..||:...:...|.|:|||.:..|    |.:..|.|..|||||.|.:|        
Mouse  1212 MIGTYQCSCNPGYQATPDRQGCTDIDECMIMNG----GCDTQCTNSEGSYECSCSEG-------- 1264

  Fly   958 CEICNTPECQCQSPYKLV--GNSCV-LSGCSSGQACPSGAECISIAGGVSY-CACPKGYQTQPD- 1017
                          |.|:  |.||. :..|.:......|.:|.:|.|  .| |.|..|:....| 
Mouse  1265 --------------YALMPDGRSCADIDECENNPDICDGGQCTNIPG--EYRCLCYDGFMASMDM 1313

  Fly  1018 GSCVDVDECEERGAQLCAFGAQCVNKPGSYSCHCPEGYQGDAYNGLCALAQRKCAADRECAANEK 1082
            .:|:||:|| :....:|.|| :|.|..||:.|||..||.                          
Mouse  1314 KTCIDVNEC-DLNPNICMFG-ECENTKGSFICHCQLGYS-------------------------- 1350

  Fly  1083 CIQPGECVCPPPYFLDPQDNNKCKSPCERFPCGINAKCTPSDPP---QCMCEAGFKGDPLLGCTD 1144
             ::.|...|        .|.::|:.....  |.::|.|.  :.|   :|.|..|:.|:. :.|.|
Mouse  1351 -VKKGTTGC--------TDVDECEIGAHN--CDMHASCL--NVPGSFKCSCREGWVGNG-IKCID 1401

  Fly  1145 EDECSH--LPCAYGAYCVNKKGGYQCVCPKDYTGDPYKSGCIFESGTPKSKCLSNDDCASNL-AC 1206
            .|||::  ..|:..|.|||..|.|:|.|.:.:|||.:             .|...|:||.|. .|
Mouse  1402 LDECANGTHQCSINAQCVNTPGSYRCACSEGFTGDGF-------------TCSDVDECAENTNLC 1453

  Fly  1207 LEGSCVSPCSSLLCGSNAYCETEQHAGWCRCRVGYVKNGDGDCVSQCQDV-ICGDGALCI--PTS 1268
            ..|.|::.       ..||        .|.|.:|:....|.   ..|||: .|....:|:  ..:
Mouse  1454 ENGQCLNV-------PGAY--------RCECEMGFTPASDS---RSCQDIDECSFQNICVFGTCN 1500

  Fly  1269 EGP---TCKCPQG-QLGNPFPGGSCS-TDQCSAARPCGERQICINGRCKERCEGVVCGIGATCDR 1328
            ..|   .|.|..| :|..  .||:|: .|:|  |.|..    |:||.|..           |..|
Mouse  1501 NLPGMFHCICDDGYELDR--TGGNCTDIDEC--ADPIN----CVNGLCVN-----------TPGR 1546

  Fly  1329 NNGKCICEPNFVGNPDLICMPPIEQAKCSPGCGEN--AHC----------------EYGLGQSR- 1374
            .  :|.|.|:|..||..:            ||.:|  .:|                |.|:|.|| 
Mouse  1547 Y--ECNCPPDFQLNPTGV------------GCVDNRVGNCYLKFGPRGDGSLSCNTEVGVGVSRS 1597

  Fly  1375 -CACNPG-TFGNPYEGCGAQSKNVCQP-NSCGPNAECRAVGNHISCLCP--QGFSGNPY-IGCQD 1433
             |.|:.| .:|||.|        .|.| ||           .....|||  :||..||. |..:|
Mouse  1598 SCCCSLGKAWGNPCE--------TCPPVNS-----------TEYYTLCPGGEGFRPNPITIILED 1643

  Fly  1434 VDECANKPCGL--NAACLNRAGGFECLCLSGHAGNPYSSCQPIESKFCQDANKCQCNERVECPEG 1496
            :|||...| ||  ...|:|..|.|:|.|..|:    |.|   .|::.|:|.::|..:..|     
Mouse  1644 IDECQELP-GLCQGGNCINTFGSFQCECPQGY----YLS---EETRICEDIDECFAHPGV----- 1695

  Fly  1497 YSCQKGQCKNLCSQASCGPRAICDAGN--CICPMGYIGDPHDQV---HGC-----SIRGQCGNDA 1551
              |..|.|.|             ..||  ||||..|:     ||   |.|     |...:..|..
Mouse  1696 --CGPGTCYN-------------TLGNYTCICPPEYM-----QVNGGHNCMDMRKSFCYRSYNGT 1740

  Fly  1552 DCLHSEICFQLGKGLRKCVDACSKI---QCGPNALCVSEDHRSSCICSDGFFGNPSNLQVGCQPE 1613
            .| .:|:.|.:.|.:..|.....|.   .|.|.....:.|.::.|       ||...........
Mouse  1741 TC-ENELPFNVTKRMCCCTYNVGKAWNKPCEPCPTPGTADFKTIC-------GNIPGFTFDIHTG 1797

  Fly  1614 RTVPEEEDKCKSDQDCSRGYGCQASVNGIKECINLCSNVVCGPNELCKINPAGHAICNCAESYVW 1678
            :.|  :.|:|                   ||...:|:|.||       ||..|...|.|...:.:
Mouse  1798 KAV--DIDEC-------------------KEIPGICANGVC-------INQIGSFRCECPTGFSY 1834

  Fly  1679 NPVVSSCEKPSLPDCTSDANCPDASACRPDVLGVLKCVAICDAFTCPANSVCVARQHQGRCDCLN 1743
            |.::..||  .:.:|::..|                        .|..|:.|:......||:|..
Mouse  1835 NDLLLVCE--DIDECSNGDN------------------------LCQRNADCINSPGSYRCECAA 1873

  Fly  1744 GFVGNPN----DRNGCQPAQKHHCRNHAEC---QESEACI-----KDESTQTLGCRPA--CDTVK 1794
            ||..:||    |||.|  .:..:..:|..|   |.|..||     |....||: |...  |:...
Mouse  1874 GFKLSPNGACVDRNEC--LEIPNVCSHGLCVDLQGSYQCICNNGFKASQDQTM-CMDVDECERHP 1935

  Fly  1795 CGPRAVCVTNNHQAQCQCPPGPFAGDPYDPFNGCQSVPCVYNHDCPPSQMCNRM------THTCF 1853
            || ...|........|.|.||               ....:|:||.....|:..      ...||
Mouse  1936 CG-NGTCKNTVGSYNCLCYPG---------------FELTHNNDCLDIDECSSFFGQVCRNGRCF 1984

  Fly  1854 D-------VCDE--------ESCGDNAICLA---EDHRAVCQ---------CPPGF--------- 1882
            :       :|:|        ::|.|...|:|   ......||         ||||:         
Mouse  1985 NEIGSFKCLCNEGYELTPDGKNCIDTNECVALPGSCSPGTCQNLEGSFRCICPPGYEVRSENCID 2049

  Fly  1883 --KGDPLPEVACTKQGGCAAGTCHPSAICEVTPEGPVCKCPPLFVGDAKSGGCRPDGQ--C---- 1939
              :.|..|.:       |..|:      |..||.|..|.|||.||.......|....|  |    
Mouse  2050 INECDEDPNI-------CLFGS------CTNTPGGFQCICPPGFVLSDNGRRCFDTRQSFCFTNF 2101

  Fly  1940 PNGDADCPA--NTICAGGVCQ--------NPCDNACGSNAECKVINRKPVCSCPL---RFQPISD 1991
            .||....|.  ||..|...|.        :||: .|..:.|....:     .||.   ....:.|
Mouse  2102 ENGKCSVPKAFNTTKAKCCCSKMPGEGWGDPCE-LCPKDDEVAFQD-----LCPYGHGTVPSLHD 2160

  Fly  1992 TAKDGCARTISKCLTDVDCGGALCYNGQC-----RIACRNSQDCSDGESCLKNVCVVACLDHSQC 2051
            |.:|     :::||.    ...:|.||||     ...|    :|..|.:.  :...|.|:|..:|
Mouse  2161 TRED-----VNECLE----SPGICSNGQCINTDGSFRC----ECPMGYNL--DYTGVRCVDTDEC 2210

  Fly  2052 ASGLACVEGHCTIGCRSNKECKQDQSCIENKCLNPCQSANSCGPNALCSIDQHHSQCSCPEGFEG 2116
            :.|..|..|.||                                |.:.|.     :|:|.|||| 
Mouse  2211 SIGNPCGNGTCT--------------------------------NVIGSF-----ECTCNEGFE- 2237

  Fly  2117 NPTPEQGCVRVPAPCLASNQCPSGHMCIGNQCNLPCTKT-----ASCAVGERCYQQVCRKVCYTS 2176
             |.|...|..:       |:|....:.    |...|..|     .:|.||....:.  :|:|...
Mouse  2238 -PGPMMNCEDI-------NECAQNPLL----CAFRCMNTFGSYECTCPVGYALRED--QKMCKDL 2288

  Fly  2177 NNCLAG-EICNS-DRTCQPGCDSDADCPPTELCLTGKCKCATGFIGTP--FGCSDIDECTEQP-- 2235
            :.|..| ..|.| ...|:            .|..|..|.|..|....|  .||.|.:||..:|  
Mouse  2289 DECAEGLHDCESRGMMCK------------NLIGTFMCICPPGMARRPDGEGCVDENECRTKPGI 2341

  Fly  2236 CHASARCENLPGTYRCVCPEGTVGDGYSQPGCSQPRQCHKPDDCANNLACIHGKCTDPCLHTVCG 2300
            |. :.||.|:.|:|||.|.||..... |...|...||               |.|....|.|:|.
Mouse  2342 CE-NGRCVNIIGSYRCECNEGFQSSS-SGTECLDNRQ---------------GLCFAEVLQTMCQ 2389

  Fly  2301 I-----NANCQSE---------GHEA-LCSCPAGFLGDPNDTGVGCFKVECIDHVDCAGDRACDA 2350
            :     |...:||         ||:. ||..|          |...:|..|......|.|     
Mouse  2390 MASSSRNLVTKSECCCDGGRGWGHQCELCPLP----------GTAQYKKICPHGPGYATD----- 2439

  Fly  2351 ETNRCIKPCDL--TSCGKGNCQVRDHKATCACYEGY--QLVNDVCEDINECLSQPCHSTAFCNNL 2411
              .|.|..|.:  :.|..|.|........|.|..||  .:....|.|::||...|......|.|.
Mouse  2440 --GRDIDECKVMPSLCTNGQCVNTMGSFRCFCKVGYTTDISGTACVDLDECSQSPKPCNFICKNT 2502

  Fly  2412 PGSYSCQCPEGLIGDPLQAGCRDPNECLSDADCPASASCQNSRCRSPCERQNACGLNANCQAQAH 2476
            .|||.|.||.|.:.......|:|.:||.:                    :|:.|           
Mouse  2503 KGSYQCSCPRGYVLQEDGKTCKDLDECQT--------------------KQHNC----------- 2536

  Fly  2477 QAICTCPLNSRGDPTIECV------HIECADNDDCSGEKACLDSKCIDPCSLPNACGALARCSVQ 2535
            |.:|   :|:.|..|.:|.      |..|.||::|.              |.|:.|||...|  |
Mouse  2537 QFLC---VNTLGGFTCKCPPGFTQHHTACIDNNECG--------------SQPSLCGAKGIC--Q 2582

  Fly  2536 NHIG--VCSCEAGSTGDAK-LGCVQLQYCQQDGQCAQGSICSHGICSPLCSTNRDCISEQLCLQG 2597
            |..|  .|.|:.|.:.||. |.|..:..|..:.:|..|  |.:.:....|.          |.||
Mouse  2583 NTPGSFSCECQRGFSLDASGLNCEDVDECDGNHRCQHG--CQNILGGYRCG----------CPQG 2635

  Fly  2598 VCQGTCKSNSSCPQFQFCSNNICTKELECRSDSECGEDETCLSDAYGRAKCESVCLGRAACGRNA 2662
            ..|          .:|:   |.|..|.||.:...||                           :|
Mouse  2636 YVQ----------HYQW---NQCVDENECSNPGACG---------------------------SA 2660

  Fly  2663 ECVARSHAPDCLCKEGF-FGDAKSGCRKIECTSDDDCSNDKSCDNHMCKIACLIGQPCGENALCT 2726
            .|.....:..|.|..|| |....|.|..:     ::||:.|:                       
Mouse  2661 SCYNTLGSYKCACPSGFSFDQFSSACHDV-----NECSSSKN----------------------- 2697

  Fly  2727 TEHHQQVCHCQPGFSGDPRVRCDVIDFCRDAPCGPGARCRNARGSYKCTCPPG---------LVG 2782
                                           ||..|  |.|..|.|.|.||||         :.|
Mouse  2698 -------------------------------PCSYG--CSNTEGGYLCGCPPGYFRVGQGHCVSG 2729

  Fly  2783 DPYNEGCRSSVECETNED---CPPHAA--CTKTNGVAK 2815
            ..:|:|...||:.|..:|   ..|.|.  | |.||..|
Mouse  2730 MGFNKGQYLSVDAEAEDDENALSPEACYEC-KINGYTK 2766

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
dpyNP_001260032.1 EGF_3 137..166 CDD:289699 11/121 (9%)
EGF_CA 212..247 CDD:238011 18/35 (51%)
EGF_CA 255..>286 CDD:214542 11/30 (37%)
EGF_CA 298..331 CDD:238011 15/32 (47%)
EGF_CA 338..373 CDD:238011 16/34 (47%)
EGF_CA 413..456 CDD:238011 19/47 (40%)
EGF_CA 457..490 CDD:238011 15/34 (44%)
EGF_CA 497..>529 CDD:214542 9/31 (29%)
EGF_CA 580..>612 CDD:214542 13/31 (42%)
EGF_3 676..702 CDD:289699 9/25 (36%)
EGF_CA 1022..1056 CDD:214542 15/33 (45%)
EGF_CA 2227..2260 CDD:238011 15/34 (44%)
EGF_CA 2393..>2422 CDD:214542 12/28 (43%)
DUF4758 4088..4282 CDD:292572
DUF4696 4127..4678 CDD:292395
DUF4758 4275..4448 CDD:292572
DUF4758 4377..4574 CDD:292572
DUF4758 4581..4754 CDD:292572
DUF4758 4683..4847 CDD:292572
DUF4758 4785..4964 CDD:292572
DUF4696 4841..5385 CDD:292395
DUF4758 4887..5098 CDD:292572
DUF4758 5193..5371 CDD:292572
DUF4758 5294..5487 CDD:292572
DUF4758 5445..5650 CDD:292572
DUF4758 5700..5877 CDD:292572
DUF4696 5756..6396 CDD:292395
DUF4758 5802..5979 CDD:292572
DUF4758 5964..6171 CDD:292572
DUF4758 6181..6360 CDD:292572
DUF4696 6339..6999 CDD:292395
DUF4758 6662..6839 CDD:292572
DUF4758 6764..6941 CDD:292572
DUF4758 6866..7045 CDD:292572
DUF4758 6968..7179 CDD:292572
DUF4696 7024..7569 CDD:292395
DUF4758 7172..7383 CDD:292572
DUF4696 7330..7964 CDD:292395
DUF4758 7400..7587 CDD:292572
DUF4758 7538..7707 CDD:292572
DUF4758 7798..7979 CDD:292572
DUF4758 7946..8126 CDD:292572
YppG 18767..>18832 CDD:290883
Med25_SD1 18795..18955 CDD:288132
MISS 19026..19258 CDD:292450
ZP 22576..22811 CDD:214579
Zona_pellucida <22714..22810 CDD:278526
Fbn2NP_034311.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 26..58
Interaction with MFAP4. /evidence=ECO:0000250|UniProtKB:P35556 149..359 30/120 (25%)