back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpy and AgaP_AGAP004166

DIOPT Version :9

Sequence 1:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster
Sequence 2:	XP_313053.5	Gene:	AgaP_AGAP004166 / 1273990	VectorBaseID:	AGAP004166	Length:	1994	Species:	Anopheles gambiae

Alignment Length:	2328	Identity:	426/2328 - (18%)
Similarity:	665/2328 - (28%)	Gaps:	798/2328 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly  4037 DQTTEFTSEIPTITPMEGSTPTPSHLETTVASITSESTTREVYTIKPFDRSTPTPVSPD------ 4095
            |...||.: :|.:..::.|||    :||.|.:           .||..||..|...:.|
Mosquito   138 DNDPEFIN-LPYVVTLDESTP----IETVVFN-----------RIKAIDRDKPNTPNSDLEYALA 186

  Fly  4096 ---------------TTVPSITFETTTNIPIG----------TTRGQVTEQTTSSPSEKRTTIRV 4135
                           :..||:..:...:...|          :.||       :.|.....||||
Mosquito   187 AKHMKSGDFPFRLEGSQRPSLVLQRALDYDAGWRSMSVQIVASDRG-------NPPRTANATIRV 244

  Fly  4136 EESTLPSRSTDRTTPSESPETPTILPSDSTTRTYSDQTTESTRDVPTT-RPFEASTPSPASLETT 4199
            .     .|..|.            ||...|...|..:..||   .|.| :|...    |..:|..
Mosquito   245 N-----LRDVDD------------LPPIFTRAQYRTRIKES---FPLTGKPIHI----PLYIEPP 285

  Fly  4200 VPSVTLETTTNDPI--GSTGGQVTEQTTSSPSE----VRTTIGLEESTLPSRSTDRTTPSESPET 4258
            :.:.. :.:.|:.:  |...|...:....||..    ::..|.|:..:||    |.|
Mosquito   286 IMAFD-QDSLNETLVYGIVAGNERQLFWISPETGVLFLQKEIDLDSESLP----DNT-------- 337

  Fly  4259 PTTLPSDFITRPHSDQTTESTRDVPTTRPFEASTPSSASLETTVPS-----VTLETTTNVPIGST 4318
                   |..:..:.|..:     ||...|.........|...||.     ..:....|:|.|.:
Mosquito   338 -------FTLQIEAQQIND-----PTKSAFARVDIEVIDLNDNVPEFEVDLYNISIIENLPKGFS 390

  Fly  4319 GGQVT--------------------------------------------EQTTSSPSEVRTTIRV 4339
            ..||.                                            ||.:|....|....||
Mosquito   391 ILQVNAIDRDQGENAEFYYYLMDEEPKGAFMIDHGSGWIVVRDETFLDKEQRSSLKMNVHAVERV 455

  Fly  4340 EESTLPSRSADRTTPSESPETPTTLPSDFTTRPHSEQTTESTRDVPTTRPFEASTPSPASLETTV 4404
            |:       .||:......:...||.......|..||.|
Mosquito   456 EQ-------YDRSRNYGKVQVEITLLDTNDNTPEFEQGT-------------------------- 487

  Fly  4405 PSVTLETTTNVPIGSTGGQV---------TGQTTSSPSEVRTT-------------IRVEESTLP 4447
             ....:|..|..|||..||:         .|:...|...||..             |||.|:...
Mosquito   488 -LYEFKTHCNASIGSKVGQIRALDPDDLGNGKIQYSIKNVRPNLVIPFLLDPDTGDIRVSEALTY 551

  Fly  4448 SRSADRTTPSESPETPTTLPSDF-ITRPHSEKTTESTRDVP-TTRPFEASTPSSASLETTVPSVT 4510
            .:.|......:.|:.|:  .|.| :.....:...:|..|:. ...|:|....:.|:
Mosquito   552 GKIAFFVEARDQPQNPS--ESRFNVALVTIDIVCQSIEDIEFIGAPYEFWVGADAA--------- 605

  Fly  4511 LETTTNVPIGSTGGQVTEQTT---------------SSPSEVRTTIRVEESTLPSRSADRTTLSE 4560
                    |||:.||:  :||               |.|..|...|. |.|.:       .|:.|
Mosquito   606 --------IGSSVGQI--RTTFDMVSDEEIFFDLLHSYPEGVPFAIE-ERSGI-------VTVIE 652

  Fly  4561 SPETPTTLPSDFTIRPHSEQTTESTRDVPTTRPFEASTPSP-ASLETTVPSVTSETTTNVPIG-- 4622
            |.|       .|..|.:..:|..|.......:..|..||.. .|||..:       .|||.|.
Mosquito   653 SME-------KFDRRCYEFETVVSYLPDSAGKNVEQLTPEAYNSLEKII-------VTNVTIHVI 703

  Fly  4623 STGGQVTGQTTAPPSEFRTTIRVEESTLPSRSTDRTTPSESPETPTILPSDSTTRTYSDQTTEST 4687
            .....:...|.|.|.||    ||:|:                 .|..:......:.:.:|.....
Mosquito   704 KHNFMLLRGTNATPIEF----RVKEN-----------------KPNTMIGQLKFQDFQEQCDADE 747

  Fly  4688 RDVPT---------------------------TRPFEASTPSPASLETTVPSVTLETTTNVPIGS 4725
            :.:|.                           .|.|.......::.....|.|..:..    ..|
Mosquito   748 KGLPPLISVRGDKNRADRQVFQLNGGKNRTRYARRFSRDVSRQSNFIRLYPLVAFDAV----FSS 808

  Fly  4726 TG-GQVTEQTTSSPS-----------EVRTTIRV--EESTLPSRSADRTTPSESPETPTTLPSDF 4776
            || |....:.:.:|:           :|..|:|:  :...:..:..||   .:......|:.:::
Mosquito   809 TGNGTRKARNSRNPTSGVQYSLVNSYDVADTVRLTNDGKLMTIKGLDR---EKQDVIRVTIIAEY 870

  Fly  4777 ITRPHSEKT----------TESTRDVPTT--RPF-----EASTPSSASLETTVPSVTLETTTNVP 4824
            .   :.::|          .|...|.|.|  :||     ..::|....:....|.:..:.....|
Mosquito   871 F---YKQRTFAGIYQVVIVVEDENDNPPTFNQPFFLGVIAENSPIGTEIVLNNPIIISDMDAAGP 932

  Fly  4825 --------IGSTGGQVTEQTTSSPSEVRTTIRVEESTLPSRSADRTTPSESPETPTTLPSDFITR 4881
                    .|.:...|.:.:.|:.|....|:......|...:.|   |.||...|     |:  |
Mosquito   933 NSEYELLLSGESNSFVAQFSNSTLSNYNKTVAHIFRNLQIANID---PGESRLRP-----DY--R 987

  Fly  4882 PHSEKTTESTRDVPTTRPFEASTPSSASLETTVPSVTLETTTNVPIGSTGGQVTEQTTSSPSEVR 4946
            |:.:           ..|..||||....|                            ...|:::.
Mosquito   988 PNKQ-----------LEPGNASTPHYNIL----------------------------FMGPNKLD 1013

  Fly  4947 TTIRVEESTLPSRSTDRTTPSESPETPTTLPSDFTTRPHSE----------QTTESTRDVPTTRP 5001
            .. .:|..||...:|||.......|....:.......|..|          :..|:|.|:.....
Mosquito  1014 RE-EIESLTLKMMATDRDNLMSEVELKILILDVNDCAPVFERIAIFRKSRCEMIENTSDLELMYL 1077

  Fly  5002 FEASTP-SPASLETTVPSVTLETTTNVPIGSTGGQVTEQTTSSPSEVRTTIRVEESTLPSRSADR 5065
            .|..|. .|..|:..:    :|..:.|..|.  ..:.|...|:|......:...:|.:.:|:|||
Mosquito  1078 DEIETEVLPEFLDAGL----MEMNSRVSYGV--DSLFEMVQSAPYVGMPRLYDSQSVMVNRTADR 1136

  Fly  5066 TTPSESPETPTTLPSDFIT---RTYSD---QTTESTRDVPTTRPFEASTPSPASLETTVPSVTSE 5124
                           :.:|   :.|..   |...:||.|......:.:.|....:...:..:|:.
Mosquito  1137 ---------------EHLTMRRKLYKQKVRQRGRNTRAVAKKSQLKFALPENVEVGKVIFKLTAN 1186

  Fly  5125 TTTNVPIGSTGGQVTGQTTAPPSEFRTTIRVEESTLPSRSTDRTTPSESPETPTTLPSDFTTRP- 5188
            ............:|.|||.....|..:..|::.:....|..:|.    .|||...|  :.|.:.
Mosquito  1187 DDDFEKNSKVFYEVVGQTELNSGERVSYFRIDRNNGELRVANRL----PPETDVKL--NITAKDV 1245

  Fly  5189 --HSDQTTESTR--DVPTTRP-FEASTPSPASLETTVPSVTLETTTNVPIGS---TG---GQVTE 5242
              .||......|  ||....| ||...                .|.||..||   ||   |||
Mosquito  1246 GGLSDMLQVQFRVYDVNDNAPVFEKQW----------------YTFNVDEGSYPITGKKIGQV-- 1292

  Fly  5243 QTTSSPSEVRTTIRVEESTLPSRSADRTTPSESPETPTLPSDFTTRPHSEQTTESTRDVPATRPF 5307
                                  |:.|..|......|..|.:|      .:|..          ||
Mosquito  1293 ----------------------RANDEDTGMNGNVTYMLITD------GDQKI----------PF 1319

  Fly  5308 EASTPSPASLETTVPSVTSEATTNVPIGSTGGQVTEQTTSSPSEVRTTIRVEESTLPSRSTDRTS 5372
            ..|     .|:.|: .|:.|....: |.|...:|.....:...::...:.||...:     ||.
Mosquito  1320 SIS-----PLDGTI-RVSGEIDREM-IASYRFRVLASDNNFDLKLSAMVDVEVIVM-----DRN- 1371

  Fly  5373 PSESPETPTTLPSDFTTRPHSDQTTECTRDVPTTRPFEASTPSSASLETTVPSVTLETTTNVPIG 5437
             ..:||        ||.   .|.......::.....:.|....:|.:.|.|..|....:.....|
Mosquito  1372 -DNNPE--------FTA---YDDLRSDRNNIKRLPVYVAYLDVNAKVGTFVKQVMARDSDFRENG 1424

  Fly  5438 STGGQVTEQTTSSPSEVRTTIRVEESTLPSRSADRTTPSESPETPT--------LPSDFTTRPHS 5494
            :  |.|....|.....::.:|..::..:  .:|.:.||||:....|        :.|||.|.|.|
Mosquito  1425 N--GLVIYSLTGQSDVLQFSIDPKDGVV--TTASKFTPSEAGTRKTYEHLNVTVVASDFGTPPRS 1485

  Fly  5495 EQT---TESTRDVPTTRPFEASTP----SSASLE----TTVPSVTLETT-----TNVP-----IG 5538
            ...   .....|.....|.|...|    ....:|    ...|.:.|..|     .|.|     :|
Mosquito  1486 SMALLIVNLQGDTLQQHPVEERPPLFPYKYYEIELRENDPAPRIVLNVTLSKRYANDPFRWEIVG 1550

  Fly  5539 STGGQVTEQTTSSPSEFRTTIRVEE---STLPSRSADRTTPSESPETPTLPSDFTTRPHSEQTTE 5600
            .|              |....|::|   |....|..||    |..::      :..|...::...
Mosquito  1551 DT--------------FDDQFRIDERNGSLWLLRPLDR----EERDS------YDVRIRVQKIKR 1591

  Fly  5601 STRDVPTTRPFEASTPSPASLETTVPSVTSETTTNVPIGSTGGQVTGQTTAPPSEVRTTIRVEES 5665
            .||::|:..         .:||..|...:.....|                   ||...|:|.:
Mosquito  1592 ETRNIPSVL---------YALENPVKRKSHRLFDN-------------------EVEIMIKVVD- 1627

  Fly  5666 TLPSRSTDRTTPSESPETP--TILPSDSTTRTYSDQTTESTRDVPTTRPFEASTPSPASLETTVP 5728
                 ..|..........|  :::| |:....|:....|:|.|       :|.:......
Mosquito  1628 -----VNDNAPVFRDNYGPIISVVP-DTANYGYAVMKVEATDD-------DAGSNGEVRY----- 1674

  Fly  5729 SVTLETTTNVP-----IGSTGGQVTGQTTATPSEVRTTIGVEESTLPSRSTDRTSPSESPETPTT 5788
                 |..|.|     |.|..||:. ...:..|......|.:     .::|||....:.   .:|
Mosquito  1675 -----TLLNEPPRLFAIDSLTGQIR-LLNSLASFKEKVFGFD-----VKATDREGADDG---KST 1725

  Fly  5789 LPSDFTTRPHSDQTTESTRDVPTTRPFEAS---TPSPASLETTVPSVTSETTTNVPIGSTGGQVT 5850
            :.:.|....|:.|              |..   ...|..:|..:..::|..:|     :||..:.
Mosquito  1726 IANVFVYVLHAHQ--------------EVCLILAGLPVDIEKQLGMISSSLST-----ATGYDIR 1771

  Fly  5851 EQTTSSPSEV------------RTTIGLEESTLPSRSTDRTSPSE-SPETP----TTLPSDFITR 5898
            .:...:.::|            |.|.||.|.|...||..|...|. .|..|    |.|..:.| .
Mosquito  1772 IRALETNTKVDDATNLYLYAIDRKTNGLVEMTELQRSLSRLDMSNLKPNLPIIELTELAVNSI-E 1835

  Fly  5899 PHSDQTTESTRDVPTTRPFEASTPSPASLETTVPS---VTSETTTN-----------VPI----- 5944
            |||               |:|:......|.|.|..   ....|.|.           :|:
Mosquito  1836 PHS---------------FDAAGMKGIELATVVIGGLIFAGGTATALCIACARYRRLIPLPNGVG 1885

  Fly  5945 --GSTGGQVTG----QTTAPPSEVRTTIGVEESTLPSRSTDRTSPSESPET-----PTTLPSD-- 5996
              |..||...|    .|:|....||.|:    |.|...|.:.|:.|..|.|     |....||
Mosquito  1886 SGGGAGGAGVGGGSSNTSAEDVRVRGTV----SRLGLGSNNNTTGSTRPITGADIQPVINRSDLK 1946

  Fly  5997 -----------FITRPHSEQTTESTRDVPTTRPFEASTPSPASLKTTVPSVTS 6038
                       |:|...:|...|.:.:...:..:|      .|||.::.|.||
Mosquito  1947 SSIFHPNFHRQFVTNISTEAVPEHSNEGNNSDSYE------DSLKDSLTSNTS 1993

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.