DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpy and AgaP_AGAP003211

DIOPT Version :9

Sequence 1:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster
Sequence 2:	XP_312919.4	Gene:	AgaP_AGAP003211 / 1273887	VectorBaseID:	AGAP003211	Length:	637	Species:	Anopheles gambiae

Alignment Length:	542	Identity:	113/542 - (20%)
Similarity:	173/542 - (31%)	Gaps:	202/542 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly 22574 VSCLADGVQVEIHITEPGFNGVLYVKGHSKDEECRRVVNLAGETVPRTEIFRVHFGSCGM--QAV 22636
            |.|....::|.|....| |.|:::.||...|..|   |:|...|...:..|.:...||||  .|.
Mosquito   100 VQCEKTHMRVNIEFDRP-FYGMIFSKGFYSDPHC---VHLKPGTGHLSATFEIFLNSCGMSSSAN 160

  Fly 22637 KDVASF------------VLVIQKHPKLVTYKAQAYNIKCV-YQTGEKNVTL-GFNVSML--TTA 22685
            .:.|||            .::||..|.:.....||..::|. |...||.||. .|.|.||  .||
Mosquito   161 HNAASFGGPTPSGSYVENTIIIQYDPYVQEVWDQARKLRCTWYDFYEKAVTFRPFQVDMLHAVTA 225

  Fly 22686 GTIANTGPPPICQMRIITNEG---EEINS-AEIGDNLKLQVDV-EPATIYGGFARSCIAKTMEDN 22745
            ..:   |....|.|:|...:|   .|::. .:||..:.:.:.: :....:....|:|:|   .|.
Mosquito   226 NFL---GDNLQCWMQIQVGKGPWASEVSGIVKIGQTMTMVLAIKDDENKFDMLVRNCVA---HDG 284

  Fly 22746 VQNEYLVTDENGCATDTSIFGNWE----YNPDTNSL-LASFNAFKFPSSDNIRFQCNIRVCFGRC 22805
            .:....:.|::||.....|...::    :.|..:.: .|.|.|||||.|.|:.|||.|:||...|
Mosquito   285 KRAPIQLVDQHGCVVRPKIMSKFQKIKNFGPSASVVSFAYFQAFKFPDSMNVHFQCVIQVCRYNC 349

  Fly 22806 QPVNCGG---------------------------------------------------YNAFGRR 22819
            ....|.|                                                   ..|:...
Mosquito   350 PEPKCAGGDYGLPALTGNGISGEYGAPGPLSGEYGPPHLSEYGVPPAAYPDPRHPSDASGAYSEN 414

  Fly 22820 RRSI------------ADNSTDA------------------------------------TAIAT- 22835
            :.|:            |:|.:|.                                    |:..|
Mosquito   415 QDSVVPAPQAQTSANSAENKSDGPVNANDRIESQPQSANPSSNDIHDHINMPPPPPPGQTSYVTV 479

  Fly 22836 -------------NSG-----------------VEGQLREEITISSNAILTFEKRSGQGLNDANI 22870
                         |||                 :.|..|...|:|........||..|.:.|.|.
Mosquito   480 TKQQKKDDGLSGENSGNLVSLGGRPRSVEGLDDLRGVRRRRDTMSVVIRPRIYKRDAQEMTDVNT 544

  Fly 22871 KPAAQRV----------------------------EDICVSMVGLIIALVITALLALVAVAVAVS 22907
            :...|.|                            |.||:|:...:..||:  ||.::|||..|:
Mosquito   545 ERIIQVVAPGDVNFALNNASGNETVVIQSQRTVDPETICMSVPSFVGGLVM--LLLVLAVASLVA 607

  Fly 22908 CWLMA----YRRRPKTIAPLPH 22925
            .:|..    :.|:..|.:..||
Mosquito   608 AFLFVRVRHFDRKGTTASRRPH 629

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpy	NP_001260032.1	EGF_3	137..166	CDD:289699
		EGF_CA	212..247	CDD:238011
		EGF_CA	255..>286	CDD:214542
		EGF_CA	298..331	CDD:238011
		EGF_CA	338..373	CDD:238011
		EGF_CA	413..456	CDD:238011
		EGF_CA	457..490	CDD:238011
		EGF_CA	497..>529	CDD:214542
		EGF_CA	580..>612	CDD:214542
		EGF_3	676..702	CDD:289699
		EGF_CA	1022..1056	CDD:214542
		EGF_CA	2227..2260	CDD:238011
		EGF_CA	2393..>2422	CDD:214542
		DUF4758	4088..4282	CDD:292572
		DUF4696	4127..4678	CDD:292395
		DUF4758	4275..4448	CDD:292572
		DUF4758	4377..4574	CDD:292572
		DUF4758	4581..4754	CDD:292572
		DUF4758	4683..4847	CDD:292572
		DUF4758	4785..4964	CDD:292572
		DUF4696	4841..5385	CDD:292395
		DUF4758	4887..5098	CDD:292572
		DUF4758	5193..5371	CDD:292572
		DUF4758	5294..5487	CDD:292572
		DUF4758	5445..5650	CDD:292572
		DUF4758	5700..5877	CDD:292572
		DUF4696	5756..6396	CDD:292395
		DUF4758	5802..5979	CDD:292572
		DUF4758	5964..6171	CDD:292572
		DUF4758	6181..6360	CDD:292572
		DUF4696	6339..6999	CDD:292395
		DUF4758	6662..6839	CDD:292572
		DUF4758	6764..6941	CDD:292572
		DUF4758	6866..7045	CDD:292572
		DUF4758	6968..7179	CDD:292572
		DUF4696	7024..7569	CDD:292395
		DUF4758	7172..7383	CDD:292572
		DUF4696	7330..7964	CDD:292395
		DUF4758	7400..7587	CDD:292572
		DUF4758	7538..7707	CDD:292572
		DUF4758	7798..7979	CDD:292572
		DUF4758	7946..8126	CDD:292572
		YppG	18767..>18832	CDD:290883
		Med25_SD1	18795..18955	CDD:288132
		MISS	19026..19258	CDD:292450
		ZP	22576..22811	CDD:214579	72/262 (27%)
		Zona_pellucida	<22714..22810	CDD:278526	27/101 (27%)
AgaP_AGAP003211	XP_312919.4	ZP	101..354	CDD:214579	72/262 (27%)
AgaP_AGAP003211	XP_312919.4	Zona_pellucida	<247..346	CDD:278526	26/101 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910