DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment dpy and AgaP_AGAP000427

DIOPT Version :9

Sequence 1:NP_001260032.1 Gene:dpy / 318824 FlyBaseID:FBgn0053196 Length:22949 Species:Drosophila melanogaster
Sequence 2:XP_310672.5 Gene:AgaP_AGAP000427 / 1271818 VectorBaseID:AGAP000427 Length:1907 Species:Anopheles gambiae


Alignment Length:2391 Identity:444/2391 - (18%)
Similarity:622/2391 - (26%) Gaps:1063/2391 - (44%)


- Green bases have known domain annotations that are detailed below.


  Fly   913 QCQDVDECSVQRGKPACGLNALCKNLPGSYECRCPQGHNGNPFIMCEI----------------- 960
            :|..|..||:      ||.|..            .:|...|||....:                 
Mosquito    23 KCACVLRCSI------CGSNTR------------QEGEKRNPFAATNMRLVVLVATVVLLAANVS 69

  Fly   961 ----------------CNTPECQCQSPYKLVGNSCVLSG--CSSGQACPSGAECISIAGGVSY-- 1005
                            |...|.||::      .:|:.:.  |:..|.|..|::    ..|..|  
Mosquito    70 AGKVESEKKSTAASKSCGAHEFQCEN------GACIPAAGHCNDIQDCADGSD----ESGCDYFL 124

  Fly  1006 CACPKGYQTQPDGSCVDVDECEERGAQLCAFGAQCVNKPGSYSCHCPEGYQGDAYNGLCALAQRK 1070
            |..|..|:.:.:.:|:.       |:..|.....|:......:|   :.|:......||:.|:..
Mosquito   125 CRAPFWYRCRHESTCIS-------GSSRCDGQRDCLGGDDEENC---DNYEVPHRAPLCSKAEFT 179

  Fly  1071 CAADRECAANEKCIQPGECVCP-PPYFLDPQDN--------NKCKSPCERFPCGINAKCTPSDPP 1126
            | .||.|.       |.:.||. ..:.||..|.        .|||.    |.|. |..|..|...
Mosquito   180 C-TDRACI-------PADLVCDGVQHCLDGSDETIGCIDIAGKCKG----FLCR-NKHCLQSHHW 231

  Fly  1127 QCMCEAGFKGDPLLGC---TDEDECSHLPCAYGAYCVNKKGGYQCVCPKDYTGDPYKSGCIFESG 1188
            .|        |.|..|   :||:.|                               .|.|..|.|
Mosquito   232 VC--------DGLDDCGDGSDEEHC-------------------------------LSECTLEHG 257

  Fly  1189 TPKSKCLSNDDCASNLACLEGSCVSPCSSLLCGSNAYCETEQHAGWCRCRVGYVKNGDGDCVSQC 1253
                    ..:||:|..|::                              |..|.||..|     
Mosquito   258 --------KYECANNHTCVD------------------------------VTQVCNGADD----- 279

  Fly  1254 QDVICGDGALCIPTSEGPTCKCPQGQLGNPFPGGSCSTDQCSAARPCGERQICINGRCKERCEGV 1318
                ||||     :.|||.||.|              .|.|.|..                    
Mosquito   280 ----CGDG-----SDEGPGCKVP--------------ADGCKALH-------------------- 301

  Fly  1319 VCGIGATCDRNNGKCICEPNFVGNPDLICMPPIEQAKCSPGCGENAHCEYGLGQSRCACNPGTFG 1383
                                                                             
Mosquito   302 ----------------------------------------------------------------- 301

  Fly  1384 NPYEGCGAQSKNVCQPNSCGPNAECRAVGNHISCLCPQGFSGNPYIG-CQDVDECANKPCGL-NA 1446
                         |.|.:|....:.:.|     |||..||...|..| |.||:|||.  .|| :.
Mosquito   302 -------------CAPQTCKVLPDGKPV-----CLCGVGFRFEPSAGRCVDVNECAR--YGLCSQ 346

  Fly  1447 ACLNRAGGFECLCLSGHAGNPYSSCQPIESKFCQDANKCQCNERVECPEGYSCQKGQCKNLCSQA 1511
            .|:|..|.|.|.|:.             :....:|...|:.:...|....|:.||          
Mosquito   347 GCINTPGSFRCTCID-------------QFHLMRDGRTCELSSGTEALMLYTTQK---------- 388

  Fly  1512 SCGPRAICDAGNCICPMGYIGDPHDQVHGCSIRGQCGNDADCLHSEICFQLGKGLRKCVDACSKI 1576
            :.|...:......     |:.....||.|.:..|......|..|.....:     |...|...::
Mosquito   389 AVGAMYLTSLHQY-----YVAKELSQVIGVAYDGSHVYWTDISHKTESIE-----RSLEDGSDRV 443

  Fly  1577 QCGPNALCVSEDHRSSCICSDGFFGNPSNLQVGCQPERTVPEEEDKCKSDQDCSRGYGCQASV-- 1639
            |.....|...||.....:..:.:|.:...:.:..            |.||     ||.|:|.|  
Mosquito   444 QLLTAGLISPEDIALDWLTGNIYFSDSGQMHIAV------------CSSD-----GYHCRAIVQD 491

  Fly  1640 -------------NGIKECINLCSNVVCG-------------------PNELCKINPAGHAICNC 1672
                         ||.....:..:|.:.|                   ||.|....|        
Mosquito   492 ELHKPRGIALLPQNGTLFYSDWGNNAMIGRARMDGTEQQVVVSDGIHWPNGLTLDWP-------- 548

  Fly  1673 AESYVW-NPVVSSCEKPSLPDCTSDANCPDASACRPDVLGVL-----------KCVAICDAFTCP 1725
            .:...| :..:...|.... |.|......|.....|..:.|.           |.:..||.||..
Mosquito   549 NQRLYWIDAKLKRIESMHF-DGTDRVVVLDDVLKHPFSIAVFNDRLYWSDWDTKSIQSCDKFTGK 612

  Fly  1726 ANSVCVARQHQGRCDCLNGFVGNPNDR---------NGCQPAQKHHCRNHAECQESEACIKDEST 1781
            .....|                  :||         :..||...|.|.||.              
Mosquito   613 MRQTLV------------------HDRMIFDVHVYHSSIQPKVSHACANHT-------------- 645

  Fly  1782 QTLGCRPACDTVKCGPRAVCVTNNHQAQCQCPPG------------------------------- 1815
                |...|          .:|:|....|.||.|                               
Mosquito   646 ----CTHLC----------LLTSNATYACACPQGMELSRDKHSCASVAKRQDILLGIGHYLVTIK 696

  Fly  1816 --PFA------GDPYD-------PFNGC--------QSVPCVY---------------------- 1835
              ||.      |:|..       .||..        .|...:|                      
Mosquito   697 HHPFGRHATGRGEPLPVATISRLAFNSLTGELFVADNSRRAIYTVELGSLRTQRLVRSGIGRITA 761

  Fly  1836 -------------------------------------NHDCP------------------PS--- 1842
                                                 ..|.|                  ||   
Mosquito   762 LAFDYLSNTLYWSDAERSTIEIYSLQTRHRSIIQHYLGDDAPVALALIPETGKMFVALRSPSGHT 826

  Fly  1843 -----QMCNRMTHTCFDVCDEE--SCGDNAICLAEDHRAVCQCPPG--------FKGDP------ 1886
                 .|..|..||  .|.:|.  |.|..:..:.:|.|:|.....|        |:||.      
Mosquito   827 HIDRQDMTGRGPHT--HVIEERLGSNGTISFAVDQDLRSVFWSDSGTNRIEITSFEGDTRHLFRE 889

  Fly  1887 -LPE-VACTKQGGCAAGTCHPS------------AICEVTPEGPVCKCPPLFVGD------AKSG 1931
             |.| |:....|.....||..|            |...::.:.|    |.|.|.|      ::..
Mosquito   890 YLREPVSLAIIGSELFWTCRGSQRLYWSDKHNVGATKRISVQLP----PDLAVPDEMPIAASQPT 950

  Fly  1932 GCRPDGQCPNGDADCPANTIC-AGGVCQNPCDNACGSNAECKVINRKPVCSCPLRFQPISDTAKD 1995
            ..|||..|...:..|  :.|| |||:..:.|                 ||...:.|.        
Mosquito   951 TRRPDHPCTRSNGGC--SHICVAGGLYTSAC-----------------VCPTGMVFN-------- 988

  Fly  1996 GCARTISKCLTDVDCGGALCYNGQC---RIACRNSQDC---SDGESCLKNVCVVACLDHSQCASG 2054
               .|:::...|.......|.:|:|   .:.|....||   ||.:.|           .|:...|
Mosquito   989 ---TTLARVCIDAAACAFRCASGECLARGLRCNGRVDCMDQSDEQGC-----------ESKTPGG 1039

  Fly  2055 LACVEGHCTIGCRSNK-ECKQDQSCIENKCLNPCQSANSC---GPNALCSIDQHHSQC-----SC 2110
            ..      |.|||.|: .|.....||  ...:.|.|...|   ...|.|......:.|     ||
Mosquito  1040 AG------TTGCRWNEFRCADGSRCI--AATSRCDSRPDCADRSDEANCEGYNRRTNCTRYQFSC 1096

  Fly  2111 PEGFEGNPTPEQGCVRVPAPCLASNQCPSG---HMC--IGNQCNLPCTKTASCAVGE-RCYQQVC 2169
            .:||         ||...|.|.....||.|   ..|  :|.:..:..|   :||.|. ||     
Mosquito  1097 ADGF---------CVDATARCDQVPDCPDGSDEQECAGVGGKGGVAAT---TCAAGMFRC----- 1144

  Fly  2170 RKVCYTSNNCLAGE-ICNSDRTCQPGCDSDADCPPT------------ELCLTGKCKCATGF-IG 2220
                 .|..|:.|. .|:....|....|....|.|.            |.|..|:.:|..|| |.
Mosquito  1145 -----NSGQCVPGSWECDGSPDCHDASDEHESCQPAEKKQEEGKGKEQERCGEGRFRCGVGFCIS 1204

  Fly  2221 TPFGCSDIDEC----------------------------TEQPCHASARCENLPGTYRC----VC 2253
            :...|...|:|                            |...|..|..|  ||...||    .|
Mosquito  1205 SALVCDGNDDCGDGTDEEHCVGRIGATAAQCSEQAIANGTAYRCARSGAC--LPAAARCNGTAEC 1267

  Fly  2254 PEGTVGDGYSQPGCSQPRQCHKPDDCA-NNLACIHGKCTDP---CLHTVCGINANCQSEGHEALC 2314
            |.|.     .:.|||         :|. ....|..|:|...   |.|     :.:|.....|.  
Mosquito  1268 PHGE-----DETGCS---------NCGLREFQCSDGQCIRQEWRCDH-----DQDCDDGSDER-- 1311

  Fly  2315 SCPAGFLG------------DPNDTGVGCFKVECIDHVD-CAGDRAC---DAETNRCIKPC--DL 2361
            :|.||..|            |..:.|.|    |||.... |.|.|.|   ..|...|...|  .|
Mosquito  1312 NCTAGADGSTAHTHAIDCGRDTFECGPG----ECIPVAKLCDGRRDCTNGHDEEGACASACTGGL 1372

  Fly  2362 TSCGKGNCQVRDHKATCACYEGYQLVND--VCEDINECL-SQPCHSTAFCNNLPGSYSCQCPEGL 2423
            ..|.: .||.....:.|||.|||:|..|  .|.|:|||. .|||...  |.|:.|||.|.|.:|.
Mosquito  1373 GPCAQ-ICQKSPAGSICACLEGYELAGDRKTCTDVNECARGQPCAQQ--CANVHGSYRCACHDGF 1434

  Fly  2424 IGDPLQAGCRD----PNECLSDADCPASASCQNSRCRSPCERQNACGLNANCQAQAHQAICTCPL 2484
            :..|.:|.|:.    |:...:..|                              |..|      |
Mosquito  1435 MLRPDKASCKSVGPAPHLLYTALD------------------------------QVRQ------L 1463

  Fly  2485 NSRGDPTIECV------HIECADNDDCSGEKACLDSKCIDPCSLPNACGALARCSVQNHIGVCSC 2543
            ..:..|.|:.|      .|...|.|                              |:..      
Mosquito  1464 TLQQPPRIDTVLRANGSRITALDLD------------------------------VRQR------ 1492

  Fly  2544 EAGSTGDAKLGCVQLQYCQQDGQCAQGSICSHGICSPLCSTNRDCI------SEQLCLQGVCQGT 2602
                         :|.|..::|    .::..|.:     .||...:      .::|.:..|....
Mosquito  1493 -------------RLYYAAENG----AALYEHDL-----RTNETRVLANVGRPDRLAVDWVAGNV 1535

  Fly  2603 CKSNSSCPQFQFCSNNICTKELECRSDSECGEDETCLSDAYGRAKCESVCLGRAACGRNAECVAR 2667
            ..::::.|..:.|.                                    .||.||.|.|....|
Mosquito  1536 YFADATEPSLKVCH------------------------------------FGRGACARVASFSQR 1564

  Fly  2668 SH----APDCLCKEGFFGDAKSGCRKIECTSDDDCSNDKSCDNHMCK----IACLIGQPCGE--- 2721
            ::    |.|.:.:..|:....|...::..|.......|.|....:.|    ::.|...|..:   
Mosquito  1565 NYVKAVAVDPVNRYLFYALLFSWIFQVPHTIVYRARLDGSLQEIVTKQAGIVSALAVDPQAQLLY 1629

  Fly  2722 ------NALCTTEHHQQ----VCHCQPGFSGDPRVRCDVID----FCRDAPCGPGARCRNARGSY 2772
                  |.|...::..|    :...|||....| |:..|.:    ....||.|...:|: ..|.|
Mosquito  1630 YTELAGNTLRRVDYLGQGQRVLAEDQPGLLHQP-VQLSVYENQALVVNRAPPGSIGQCQ-LYGQY 1692

  Fly  2773 KCTCPPGLVGDPYNEGCRSS----VECETNEDCPPHAACTKTNGVAKCRDVCAQLQCGPNAECVP 2833
            :|        :||......:    |..|:.:...|: .|.:.|        |..|       ||.
Mosquito  1693 RC--------EPYRVNVPPTGLLLVVQESRQPMVPN-VCDRAN--------CTHL-------CVA 1733

  Fly  2834 KGHVAQCACRSGYD-------GQPADRVAGCKP--------LPSPCQVTGD 2869
            .|.||:|.|.:|.:       .:|.|.....||        ..:|.|.|.|
Mosquito  1734 VGPVARCICENGLEIAEGDRCAEPKDGARAMKPYRGTVLVGAAAPAQPTTD 1784

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dpyNP_001260032.1 EGF_3 137..166 CDD:289699
EGF_CA 212..247 CDD:238011
EGF_CA 255..>286 CDD:214542
EGF_CA 298..331 CDD:238011
EGF_CA 338..373 CDD:238011
EGF_CA 413..456 CDD:238011
EGF_CA 457..490 CDD:238011
EGF_CA 497..>529 CDD:214542
EGF_CA 580..>612 CDD:214542
EGF_3 676..702 CDD:289699
EGF_CA 1022..1056 CDD:214542 4/33 (12%)
EGF_CA 2227..2260 CDD:238011 13/64 (20%)
EGF_CA 2393..>2422 CDD:214542 14/29 (48%)
DUF4758 4088..4282 CDD:292572
DUF4696 4127..4678 CDD:292395
DUF4758 4275..4448 CDD:292572
DUF4758 4377..4574 CDD:292572
DUF4758 4581..4754 CDD:292572
DUF4758 4683..4847 CDD:292572
DUF4758 4785..4964 CDD:292572
DUF4696 4841..5385 CDD:292395
DUF4758 4887..5098 CDD:292572
DUF4758 5193..5371 CDD:292572
DUF4758 5294..5487 CDD:292572
DUF4758 5445..5650 CDD:292572
DUF4758 5700..5877 CDD:292572
DUF4696 5756..6396 CDD:292395
DUF4758 5802..5979 CDD:292572
DUF4758 5964..6171 CDD:292572
DUF4758 6181..6360 CDD:292572
DUF4696 6339..6999 CDD:292395
DUF4758 6662..6839 CDD:292572
DUF4758 6764..6941 CDD:292572
DUF4758 6866..7045 CDD:292572
DUF4758 6968..7179 CDD:292572
DUF4696 7024..7569 CDD:292395
DUF4758 7172..7383 CDD:292572
DUF4696 7330..7964 CDD:292395
DUF4758 7400..7587 CDD:292572
DUF4758 7538..7707 CDD:292572
DUF4758 7798..7979 CDD:292572
DUF4758 7946..8126 CDD:292572
YppG 18767..>18832 CDD:290883
Med25_SD1 18795..18955 CDD:288132
MISS 19026..19258 CDD:292450
ZP 22576..22811 CDD:214579
Zona_pellucida <22714..22810 CDD:278526
AgaP_AGAP000427XP_310672.5 LDLa 86..120 CDD:238060 9/43 (21%)
LDLa 128..161 CDD:238060 6/39 (15%)
LDLa 173..204 CDD:238060 11/38 (29%)
LDLa 218..248 CDD:238060 11/38 (29%)
LDLa 257..286 CDD:238060 14/80 (18%)
EGF_CA 334..373 CDD:214542 14/53 (26%)
Ldl_recept_b 419..459 CDD:278487 8/44 (18%)
NHL <449..604 CDD:302697 28/180 (16%)
NHL repeat 453..485 CDD:271320 8/48 (17%)
NHL repeat 493..535 CDD:271320 4/41 (10%)
LY 530..572 CDD:214531 8/50 (16%)
NHL repeat 540..572 CDD:271320 8/40 (20%)
NHL repeat 581..604 CDD:271320 3/22 (14%)
FXa_inhibition 643..675 CDD:291342 10/59 (17%)
NHL 726..>882 CDD:302697 19/157 (12%)
LY 749..791 CDD:214531 0/41 (0%)
NHL repeat 759..799 CDD:271320 0/39 (0%)
NHL repeat 803..845 CDD:271320 8/43 (19%)
LDLa 1003..1032 CDD:238060 8/28 (29%)
LDLa 1045..1080 CDD:238060 10/36 (28%)
LDLa 1089..1123 CDD:238060 12/42 (29%)
LDLa 1136..1168 CDD:197566 10/41 (24%)
LDLa 1190..1224 CDD:238060 9/33 (27%)
LDLa 1279..1313 CDD:238060 8/40 (20%)
LDLa 1329..1362 CDD:238060 11/36 (31%)
FXa_inhibition 1373..1403 CDD:291342 11/30 (37%)
EGF_CA 1405..1437 CDD:238011 15/33 (45%)
LY 1513..1550 CDD:214531 4/72 (6%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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