DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpy and AgaP_AGAP011526

DIOPT Version :9

Sequence 1:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster
Sequence 2:	XP_307205.4	Gene:	AgaP_AGAP011526 / 1268644	VectorBaseID:	AGAP011526	Length:	1376	Species:	Anopheles gambiae

Alignment Length:	232	Identity:	48/232 - (20%)
Similarity:	72/232 - (31%)	Gaps:	106/232 - (45%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 EVFYLNLENGYFGCQVNESTEYLQLF----------------------NLSKLCDGTQDCFLGAD 85
            ::..::|.||....:.|.:.:...||                      ||.::.|.|:   |..|
Mosquito  1095 DIIIISLSNGTVRARRNANRDLDVLFTVRNGQTGGFYAGHEIRRVIDENLEEIEDATK---LQID 1156

  Fly    86 ELSKELKCTNDCDKDGTKCTHGACLNGV---------------------------CHCNDGYGGC 123
            |:.|. ||..:      .|.||.|.:.:                           |.|.:||||.
Mosquito  1157 EVVKS-KCLPN------YCIHGECEDRIVLDAKLIHPVSTDVTSFVSARHAHRMECACREGYGGD 1214

  Fly   124 NCVDKDENECKQRPCDVFAHCTNTLGSFTCTCFPGYRGNGFHCEDIDECQDPAIAARCVENAECC 188
            .| ....|||.:.||..:.           ||.|.....|:|
Mosquito  1215 KC-QHAVNECSKAPCPPYK-----------TCIPDSSDQGYH----------------------- 1244

  Fly   189 NLPAHFLCKCKDGYEG---DGEV-LCTDVDECRNPEN 221
                   |.|::|:.|   |.:: ||.| :.|..|.|
Mosquito  1245 -------CTCREGFAGPKCDRDITLCHD-ETCYVPRN 1273

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpy	NP_001260032.1	EGF_3	137..166	CDD:289699	6/28 (21%)
		EGF_CA	212..247	CDD:238011	4/10 (40%)
		EGF_CA	255..>286	CDD:214542
		EGF_CA	298..331	CDD:238011
		EGF_CA	338..373	CDD:238011
		EGF_CA	413..456	CDD:238011
		EGF_CA	457..490	CDD:238011
		EGF_CA	497..>529	CDD:214542
		EGF_CA	580..>612	CDD:214542
		EGF_3	676..702	CDD:289699
		EGF_CA	1022..1056	CDD:214542
		EGF_CA	2227..2260	CDD:238011
		EGF_CA	2393..>2422	CDD:214542
		DUF4758	4088..4282	CDD:292572
		DUF4696	4127..4678	CDD:292395
		DUF4758	4275..4448	CDD:292572
		DUF4758	4377..4574	CDD:292572
		DUF4758	4581..4754	CDD:292572
		DUF4758	4683..4847	CDD:292572
		DUF4758	4785..4964	CDD:292572
		DUF4696	4841..5385	CDD:292395
		DUF4758	4887..5098	CDD:292572
		DUF4758	5193..5371	CDD:292572
		DUF4758	5294..5487	CDD:292572
		DUF4758	5445..5650	CDD:292572
		DUF4758	5700..5877	CDD:292572
		DUF4696	5756..6396	CDD:292395
		DUF4758	5802..5979	CDD:292572
		DUF4758	5964..6171	CDD:292572
		DUF4758	6181..6360	CDD:292572
		DUF4696	6339..6999	CDD:292395
		DUF4758	6662..6839	CDD:292572
		DUF4758	6764..6941	CDD:292572
		DUF4758	6866..7045	CDD:292572
		DUF4758	6968..7179	CDD:292572
		DUF4696	7024..7569	CDD:292395
		DUF4758	7172..7383	CDD:292572
		DUF4696	7330..7964	CDD:292395
		DUF4758	7400..7587	CDD:292572
		DUF4758	7538..7707	CDD:292572
		DUF4758	7798..7979	CDD:292572
		DUF4758	7946..8126	CDD:292572
		YppG	18767..>18832	CDD:290883
		Med25_SD1	18795..18955	CDD:288132
		MISS	19026..19258	CDD:292450
		ZP	22576..22811	CDD:214579
		Zona_pellucida	<22714..22810	CDD:278526
AgaP_AGAP011526	XP_307205.4	Cadherin_repeat	13..108	CDD:206637
		Cadherin_repeat	116..222	CDD:206637
		Cadherin_repeat	230..328	CDD:206637
		Cadherin_repeat	337..430	CDD:206637
		Cadherin_repeat	439..534	CDD:206637
		Cadherin_repeat	542..638	CDD:206637
		Cadherin_repeat	646..743	CDD:206637
		Cadherin_repeat	751..848	CDD:206637
		CA	889..955	CDD:214520
		Cadherin_repeat	972..1054	CDD:206637
		EGF_CA	1220..1256	CDD:238011	14/76 (18%)
		LamG	1274..>1376	CDD:238058	48/232 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1219
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900