DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpy and AgaP_AGAP011529

DIOPT Version :9

Sequence 1:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster
Sequence 2:	XP_307203.4	Gene:	AgaP_AGAP011529 / 1268641	VectorBaseID:	AGAP011529	Length:	652	Species:	Anopheles gambiae

Alignment Length:	604	Identity:	123/604 - (20%)
Similarity:	187/604 - (30%)	Gaps:	197/604 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly  7296 TLEIAVPPVTSETTTN----------------------VAIGSTGGQVTEQTTSSPSEVRTTIR- 7337
            |...|:|.:...:.||                      :..|...|....:.|..|.|....:.
Mosquito   107 TYAFALPDILENSNTNIFGIVRVTDKDKGVHGQIKSLDIVDGDPDGHFRIKPTDRPGEYVIEVHR 171

  Fly  7338 -VEESTLPS------RSTDRTTPSESP--ETPTTLPSDFTTRPHSDQTTESTRDVPTTRPFEAST 7393
             ::..|.|:      |:.||..|.:..  .||..| :|.     :|......|::     :|.|.
Mosquito   172 LLDRETAPAGYNLTLRAVDRGVPPKQSYLVTPVRL-ADI-----NDNAPVFNREI-----YEVSV 225

  Fly  7394 PSPASLETTVPSVTLETT-------TSVPMGSTGGQVTGQTTAPPSEVRTTIRVEESTLPSRSTD 7451
            |..:...|  |.:.|:.|       ..|.:...||...|:           .||
Mosquito   226 PETSPPNT--PVIRLKVTDRDEGKNAKVFLEIVGGNEGGE-----------FRV----------- 266

  Fly  7452 RTPPSESPETP---TTLPSD-----FTTRPHS--DQTTESSRDVPTTQPFESSTPRPVTLEIAVP 7506
                  :|||.   |.:|.|     |.|...|  ||....:|.       :||....:.::
Mosquito   267 ------NPETGMLYTAVPLDAELKAFYTLTVSAIDQGNPGTRK-------QSSAKVKINVQ---- 314

  Fly  7507 PVTSETTTNVPIGSTGGQVTGQTTATPSEVRTTIGVEESTLPSRSTDRTTP-----------SES 7560
                :|..|.||..|              ...||.|:|:.....|..:.|.           |.|
Mosquito   315 ----DTNDNDPIFET--------------ANLTIYVDENEPAGTSVTKVTARDKDLGENAYISYS 361

  Fly  7561 PETPTTLPSDF-----TTRPHSDQTTESTRDVPTTRP--------FEASTPSPASLETTVPSVTL 7612
            ......:|.|.     |.|.......||.|.....|.        ::...|. .|:...:|...|
Mosquito   362 IANLNDVPFDIDHFSGTVRTSKLLDYESMRREYVLRDEYLLNITVYDLGKPQ-KSISKILPLTIL 425

  Fly  7613 ETTTNVP------------IGSTGGQVTGQTTATPSEVRTTIGVEESTLPSRSTDRTTPSESPET 7665
            :...|||            ..:..|.:..:..||.::    :|.......|..||.......|||
Mosquito   426 DENDNVPKFEKSLASFRVTENAINGTIIFRVKATDAD----LGQNAKITYSLVTDTKDFRVDPET 486

  Fly  7666 ---PTTLPSDFTTRPHSD------QTTESTRDVPTTRPFEASTPRPVTL--------ETAVPSVT 7713
               ....|.|   |...:      :.|:...|..|...:..:..| ||:        |.||..:|
Mosquito   487 GVLTVVAPLD---RERQEVYELKIRATDGGGDQNTPALYSDALVR-VTVDDINDNAPEFAVQDLT 547

  Fly  7714 SETTTNVPIGSTVT--------SETTTNV--PIGSTG-GQVAGQTTAPPSEVRTT--IRVEESTL 7765
            .....:||.|:.||        |.|::.:  ..|..| |:.:.:.......:||.  :..||..:
Mosquito   548 VRIREDVPRGTVVTVVSAIDLDSGTSSEIVYSFGENGDGEGSFRIDKQSGTIRTARMLDFEERQV 612

  Fly  7766 PS---RSADRTTPSESPET 7781
            .|   ::.||.|||.|.||
Mosquito   613 HSLIVKAIDRGTPSLSSET 631

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpy	NP_001260032.1	EGF_3	137..166	CDD:289699
		EGF_CA	212..247	CDD:238011
		EGF_CA	255..>286	CDD:214542
		EGF_CA	298..331	CDD:238011
		EGF_CA	338..373	CDD:238011
		EGF_CA	413..456	CDD:238011
		EGF_CA	457..490	CDD:238011
		EGF_CA	497..>529	CDD:214542
		EGF_CA	580..>612	CDD:214542
		EGF_3	676..702	CDD:289699
		EGF_CA	1022..1056	CDD:214542
		EGF_CA	2227..2260	CDD:238011
		EGF_CA	2393..>2422	CDD:214542
		DUF4758	4088..4282	CDD:292572
		DUF4696	4127..4678	CDD:292395
		DUF4758	4275..4448	CDD:292572
		DUF4758	4377..4574	CDD:292572
		DUF4758	4581..4754	CDD:292572
		DUF4758	4683..4847	CDD:292572
		DUF4758	4785..4964	CDD:292572
		DUF4696	4841..5385	CDD:292395
		DUF4758	4887..5098	CDD:292572
		DUF4758	5193..5371	CDD:292572
		DUF4758	5294..5487	CDD:292572
		DUF4758	5445..5650	CDD:292572
		DUF4758	5700..5877	CDD:292572
		DUF4696	5756..6396	CDD:292395
		DUF4758	5802..5979	CDD:292572
		DUF4758	5964..6171	CDD:292572
		DUF4758	6181..6360	CDD:292572
		DUF4696	6339..6999	CDD:292395
		DUF4758	6662..6839	CDD:292572
		DUF4758	6764..6941	CDD:292572
		DUF4758	6866..7045	CDD:292572
		DUF4758	6968..7179	CDD:292572
		DUF4696	7024..7569	CDD:292395	62/332 (19%)
		DUF4758	7172..7383	CDD:292572	22/118 (19%)
		DUF4696	7330..7964	CDD:292395	114/548 (21%)
		DUF4758	7400..7587	CDD:292572	44/219 (20%)
		DUF4758	7538..7707	CDD:292572	42/221 (19%)
		DUF4758	7798..7979	CDD:292572
		DUF4758	7946..8126	CDD:292572
		YppG	18767..>18832	CDD:290883
		Med25_SD1	18795..18955	CDD:288132
		MISS	19026..19258	CDD:292450
		ZP	22576..22811	CDD:214579
		Zona_pellucida	<22714..22810	CDD:278526
AgaP_AGAP011529	XP_307203.4	Cadherin_repeat	2..93	CDD:206637
		Cadherin_repeat	115..212	CDD:206637	17/102 (17%)
		Cadherin_repeat	220..319	CDD:206637	28/148 (19%)
		Cadherin_repeat	329..430	CDD:206637	20/101 (20%)
		Cadherin_repeat	440..537	CDD:206637	19/104 (18%)
		Cadherin_repeat	547..643	CDD:206637	24/85 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1219
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900