DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpy and KRT40

DIOPT Version :9

Sequence 1:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster
Sequence 2:	NP_001372146.1	Gene:	KRT40 / 125115	HGNCID:	26707	Length:	431	Species:	Homo sapiens

Alignment Length:	572	Identity:	103/572 - (18%)
Similarity:	154/572 - (26%)	Gaps:	253/572 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly  2447 SASCQNSRCRSPCERQNACGLNANCQAQAHQAICTCPLNSRGDPTIECVHIECADNDDCSGEKAC 2511
            ::.|.::.| ||    .:||..:.|          .|.:|                  ||.|.||
Human     2 TSDCSSTHC-SP----ESCGTASGC----------APASS------------------CSVETAC 33

  Fly  2512 LDSKCIDPCSLPNACGALARCSVQNHIGVCSCEAGSTGDAKLGCVQLQYCQQDGQCAQGSICSHG 2576
            |...|           |.:||...:.:   |...|.|     ||  |..|...|.|  .|.|..|
Human    34 LPGTC-----------ATSRCQTPSFL---SRSRGLT-----GC--LLPCYFTGSC--NSPCLVG 75

  Fly  2577 ICSPLCSTNRDCISEQLCLQGVCQGTCKSNSSCPQFQFCSNNICT------------KELECRSD 2629
            .|:             .|..||.....|..     .||.::.:.:            .|||.|..
Human    76 NCA-------------WCEDGVFTSNEKET-----MQFLNDRLASYLEKVRSLEETNAELESRIQ 122

  Fly  2630 SECGEDETCLSDAYGRAKCESVCLGRAACGRNAECVARSHAPDCLCKEGFFGDAKSGCRKIECTS 2694
            .:|.:|            ...||                  ||   .:.:|...:...:||.||.
Human   123 EQCEQD------------IPMVC------------------PD---YQRYFNTIEDLQQKILCTK 154

  Fly  2695 DDDCSNDKSCDNHMCKIA-----------------------CLIG----------------QPCG 2720
            .::.......||  ||:|                       .|.|                :...
Human   155 AENSRLAVQLDN--CKLATDDFKSKYESELSLRQLLEADISSLHGILEELTLCKSDLEAHVESLK 217

  Fly  2721 ENALCTTEHHQQVCHCQPGFSGDPRVRCDVIDFCRDAPCGPGARCRNARGSYKCTCPPGLVGDPY 2785
            |:.||..::|::..:......||   |..|     :....|...........:|.|...|..:..
Human   218 EDLLCLKKNHEEEVNLLREQLGD---RLSV-----ELDTAPTLDLNRVLDEMRCQCETVLANNRR 274

  Fly  2786 N-----------------------EGCRS------------SVECETNEDCPPHAACTKTNGVAK 2815
            .                       :||:.            .:|.:..:.......||.....|:
Human   275 EAEEWLAVQTEELNQQQLSSAEQLQGCQMEILELKRTASALEIELQAQQSLTESLECTVAETEAQ 339

  Fly  2816 CRDVCAQLQC-GPNAECVPKGHVAQCAC---------------RSGYDGQ---------PADRVA 2855
            .....||:|| ..|.|    ..:|:..|               ::..:|:         ..|...
Human   340 YSSQLAQIQCLIDNLE----NQLAEIRCDLERQNQEYQVLLDVKARLEGEINTYWGLLDSEDSRL 400

  Fly  2856 GCKPLPSPCQVTGDCPTNTYCSDSVCKPACVLDTECGAFEVCQGGQCFNPCL 2907
            .|    |||..|  |     .|.:.|:|       |.|:.:|....|   ||
Human   401 SC----SPCSTT--C-----TSSNTCEP-------CSAYVICTVENC---CL 431

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpy	NP_001260032.1	EGF_3	137..166	CDD:289699
		EGF_CA	212..247	CDD:238011
		EGF_CA	255..>286	CDD:214542
		EGF_CA	298..331	CDD:238011
		EGF_CA	338..373	CDD:238011
		EGF_CA	413..456	CDD:238011
		EGF_CA	457..490	CDD:238011
		EGF_CA	497..>529	CDD:214542
		EGF_CA	580..>612	CDD:214542
		EGF_3	676..702	CDD:289699
		EGF_CA	1022..1056	CDD:214542
		EGF_CA	2227..2260	CDD:238011
		EGF_CA	2393..>2422	CDD:214542
		DUF4758	4088..4282	CDD:292572
		DUF4696	4127..4678	CDD:292395
		DUF4758	4275..4448	CDD:292572
		DUF4758	4377..4574	CDD:292572
		DUF4758	4581..4754	CDD:292572
		DUF4758	4683..4847	CDD:292572
		DUF4758	4785..4964	CDD:292572
		DUF4696	4841..5385	CDD:292395
		DUF4758	4887..5098	CDD:292572
		DUF4758	5193..5371	CDD:292572
		DUF4758	5294..5487	CDD:292572
		DUF4758	5445..5650	CDD:292572
		DUF4758	5700..5877	CDD:292572
		DUF4696	5756..6396	CDD:292395
		DUF4758	5802..5979	CDD:292572
		DUF4758	5964..6171	CDD:292572
		DUF4758	6181..6360	CDD:292572
		DUF4696	6339..6999	CDD:292395
		DUF4758	6662..6839	CDD:292572
		DUF4758	6764..6941	CDD:292572
		DUF4758	6866..7045	CDD:292572
		DUF4758	6968..7179	CDD:292572
		DUF4696	7024..7569	CDD:292395
		DUF4758	7172..7383	CDD:292572
		DUF4696	7330..7964	CDD:292395
		DUF4758	7400..7587	CDD:292572
		DUF4758	7538..7707	CDD:292572
		DUF4758	7798..7979	CDD:292572
		DUF4758	7946..8126	CDD:292572
		YppG	18767..>18832	CDD:290883
		Med25_SD1	18795..18955	CDD:288132
		MISS	19026..19258	CDD:292450
		ZP	22576..22811	CDD:214579
		Zona_pellucida	<22714..22810	CDD:278526
KRT40	NP_001372146.1	Head	1..89		35/155 (23%)
		Filament	88..399	CDD:365827	53/362 (15%)
		Coil 1A	90..124		7/38 (18%)
		Linker 1	125..135		4/39 (10%)
		Coil 1B	136..236		16/101 (16%)
		Linker 12	237..252		5/22 (23%)
		Coil 2	253..396		18/146 (12%)
		Tail	397..431		14/54 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910