DRSC/TRiP Functional Genomics Resources

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Protein Alignment dpy and FILIP1L

DIOPT Version :9

Sequence 1:NP_001260032.1 Gene:dpy / 318824 FlyBaseID:FBgn0053196 Length:22949 Species:Drosophila melanogaster
Sequence 2:NP_001374779.1 Gene:FILIP1L / 11259 HGNCID:24589 Length:1190 Species:Homo sapiens


Alignment Length:1309 Identity:230/1309 - (17%)
Similarity:404/1309 - (30%) Gaps:400/1309 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly  3984 MRTRFTDIEAENETTGPYTTTTESYKTTK-----QLSSNPETETPTTLPSRPTTRPFT---DQTT 4040
            ||:|.:|.|...:...|..|...|::..|     |...:..:|:...||.....:|.:   .|..
Human     1 MRSRGSDTEGSAQKKFPRHTKGHSFQGPKNMKHRQQDKDSPSESDVILPCPKAEKPHSGNGHQAE 65

  Fly  4041 EFTSE--IPTITPMEGSTPTPSH--------------LETTVASITS----ESTTREVYTIKPFD 4085
            :.:.:  :..::.:||.......              ||.....:|.    |:..|:.:..|   
Human    66 DLSRDDLLFLLSILEGELQARDEVIGILKAEKMDLALLEAQYGFVTPKKVLEALQRDAFQAK--- 127

  Fly  4086 RSTP-------TPVSPDTTVPSITFETTTNIPIGTTRGQVTEQTTSSPSEKRTTIRVEESTLPSR 4143
             |||       .|::....|.....|:...|     .||:   ..:..|.::|.:.:||    .:
Human   128 -STPWQEDIYEKPMNELDKVVEKHKESYRRI-----LGQL---LVAEKSRRQTILELEE----EK 179

  Fly  4144 STDRTTPSESPETPTILPS---------DSTTRTYSDQTTESTRDVPTTRPFEASTPSPASL--- 4196
            ...:....:|.|...:|..         |...::..::..|..:.|.|.:.......|.|.:   
Human   180 RKHKEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVD 244

  Fly  4197 --ETTVPSVTLETTTNDPIGSTGGQVTEQTTSSPSEVRTTIGLEESTLPSRSTDRTTPSESPETP 4259
              :.....:||:.           |..::.|::..|..|.:.|.|:.:.......|...:..:|.
Human   245 EQQRLTAQLTLQR-----------QKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQ 298

  Fly  4260 TTLPSDFITRPHSDQ-------TTESTRDVPTTRPFEASTPSSASLETTVPSV---------TLE 4308
            |       |:.|.||       |.|.:::....:...|.:.....||.|..|:         ..|
Human   299 T-------TKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKE 356

  Fly  4309 TTTNVPIGSTGGQVTEQTTSSPSEVRTTI----------------------RVEESTLPSR---- 4347
            ..:....|:.|      ..:...|:|..:                      |:|..||.|:    
Human   357 KISKGEYGNAG------IMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKL 415

  Fly  4348 ---------------------------------SADRTT---------------------PSESP 4358
                                             ..:|.|                     .|...
Human   416 EVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLE 480

  Fly  4359 ETPTTLPSDFTTRPH------SEQTTESTRDVPTTRPFEASTPSPASLETTVPSVTLETTTNVPI 4417
            :|..||..|.|....      .|:.|.|.:...|....:|     ||.:..|....:.|.|...|
Human   481 KTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQA-----ASSQLQVEQNKVTTVTEKLI 540

  Fly  4418 GSTGGQVTGQT---------TSSPSEVRTTIRVEE---STLPSRSADRTTPSESPETPTTLPSDF 4470
            ..|...:..:|         |....:::..::.||   :.|.||........:|.|   .:..||
Human   541 EETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLE---AIEKDF 602

  Fly  4471 I------------TRPHSE--KTTESTRDV------------------PTTRPFEASTPSSASLE 4503
            :            |..|.|  |..|.:::|                  .|...:|......|:..
Human   603 LKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYANER 667

  Fly  4504 TTVPSVTLETTTNVPIGSTGGQVTEQT-TSSPSEVRTTIRVEESTLPSRSADRTTLSE------- 4560
            .....::.| ..:|.:.....::.|:| ||....:...::.||:.....|.:...|.|       
Human   668 DKAQFLSKE-LEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMA 731

  Fly  4561 SPETPTTLPSDFTI------------RPHSEQTTESTRDVPTTRPFEAS-TPSPASLETTVPSVT 4612
            :.:....|..|.::            |....:....|:::...|.|..| .||            
Human   732 TEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKSLRPS------------ 784

  Fly  4613 SETTTNVPIGSTGGQVTGQTTAPPSEFRTTIRVEESTLPSRSTDRTTPSESPETPTILPSDSTT- 4676
                           :.|:..:.|..|...::.|           ...:|.|:..:::|.:... 
Human   785 ---------------LNGRRISDPQVFSKEVQTE-----------AVDNEPPDYKSLIPLERAVI 823

  Fly  4677 --RTY--SDQTTESTRDVPTTRPFEA--STPSPASLETTVP----------SVTLETTTNVPIGS 4725
              :.|  |:...|...|..:...|:.  |||.|.:.:..:|          :..::|..|.....
Human   824 NGQLYEESENQDEDPNDEGSVLSFKCSQSTPCPVNRKLWIPWMKSKEGHLQNGKMQTKPNANFVQ 888

  Fly  4726 TGGQVTEQTTSSPSEVRTTIRVEESTLPSRSADRTTPSESPETPTTL------PSDFIT------ 4778
            .|..|...|...|..::.|....::|........||.|....|.|.:      |...||      
Human   889 PGDLVLSHTPGQPLHIKVTPDHVQNTATLEITSPTTESPHSYTSTAVIPNCGTPKQRITILQNAS 953

  Fly  4779 -RPHSEKTTESTRDVPTTRPFEASTPSSASLETTVPSVTLETTTNVPIGSTGGQVTEQTTSSPSE 4842
             .|...||  ||.|:             .:||..:..:|:.|........:.|.:|.:.|.||.:
Human   954 ITPVKSKT--STEDL-------------MNLEQGMSPITMATFARAQTPESCGSLTPERTMSPIQ 1003

  Fly  4843 VRTTIRVEESTLPSRSADRTTPSESPETPTTLPSD---FITRPHSEKTTESTRDVPTTRPFEAST 4904
            |...         :.||.......||| ||.:.:.   |...|..:.:.:          |:.|.
Human  1004 VLAV---------TGSASSPEQGRSPE-PTEISAKHAIFRVSPDRQSSWQ----------FQRSN 1048

  Fly  4905 PSSASLETTVPSVTLETTTNVPIGS-----TGGQVTEQTTSSPSEVRTTIRVEESTLPSRSTDRT 4964
            .:|:|:.||.     :...::.:||     ....|...:.|:|.:...|..:....| :::|::.
Human  1049 SNSSSVITTE-----DNKIHIHLGSPYMQAVASPVRPASPSAPLQDNRTQGLINGAL-NKTTNKV 1107

  Fly  4965 TPSESPETPTTLPSDFTTRPHSEQTTESTRDVPTTRPFEASTPSPAS-----LETTVPSVTLETT 5024
            | |....|||..|     .|...|.|  .::|...| ..|..|.|.|     :.|..|:|.::. 
Human  1108 T-SSITITPTATP-----LPRQSQIT--IKEVCKQR-IPARIPKPKSTGITKISTKAPTVPMDK- 1162

  Fly  5025 TNVPIGSTG 5033
               ||...|
Human  1163 ---PIYQNG 1168

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dpyNP_001260032.1 EGF_3 137..166 CDD:289699
EGF_CA 212..247 CDD:238011
EGF_CA 255..>286 CDD:214542
EGF_CA 298..331 CDD:238011
EGF_CA 338..373 CDD:238011
EGF_CA 413..456 CDD:238011
EGF_CA 457..490 CDD:238011
EGF_CA 497..>529 CDD:214542
EGF_CA 580..>612 CDD:214542
EGF_3 676..702 CDD:289699
EGF_CA 1022..1056 CDD:214542
EGF_CA 2227..2260 CDD:238011
EGF_CA 2393..>2422 CDD:214542
DUF4758 4088..4282 CDD:292572 38/221 (17%)
DUF4696 4127..4678 CDD:292395 112/734 (15%)
DUF4758 4275..4448 CDD:292572 42/279 (15%)
DUF4758 4377..4574 CDD:292572 44/248 (18%)
DUF4758 4581..4754 CDD:292572 31/190 (16%)
DUF4758 4683..4847 CDD:292572 40/188 (21%)
DUF4758 4785..4964 CDD:292572 37/186 (20%)
DUF4696 4841..5385 CDD:292395 45/206 (22%)
DUF4758 4887..5098 CDD:292572 35/157 (22%)
DUF4758 5193..5371 CDD:292572
DUF4758 5294..5487 CDD:292572
DUF4758 5445..5650 CDD:292572
DUF4758 5700..5877 CDD:292572
DUF4696 5756..6396 CDD:292395
DUF4758 5802..5979 CDD:292572
DUF4758 5964..6171 CDD:292572
DUF4758 6181..6360 CDD:292572
DUF4696 6339..6999 CDD:292395
DUF4758 6662..6839 CDD:292572
DUF4758 6764..6941 CDD:292572
DUF4758 6866..7045 CDD:292572
DUF4758 6968..7179 CDD:292572
DUF4696 7024..7569 CDD:292395
DUF4758 7172..7383 CDD:292572
DUF4696 7330..7964 CDD:292395
DUF4758 7400..7587 CDD:292572
DUF4758 7538..7707 CDD:292572
DUF4758 7798..7979 CDD:292572
DUF4758 7946..8126 CDD:292572
YppG 18767..>18832 CDD:290883
Med25_SD1 18795..18955 CDD:288132
MISS 19026..19258 CDD:292450
ZP 22576..22811 CDD:214579
Zona_pellucida <22714..22810 CDD:278526
FILIP1LNP_001374779.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..65 15/63 (24%)
CortBP2 66..248 CDD:401608 30/197 (15%)
SMC_prok_B 224..>773 CDD:274008 91/581 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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