DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpy and Bcr

DIOPT Version :9

Sequence 1:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster
Sequence 2:	NP_001074881.1	Gene:	Bcr / 110279	MGIID:	88141	Length:	1270	Species:	Mus musculus

Alignment Length:	674	Identity:	124/674 - (18%)
Similarity:	219/674 - (32%)	Gaps:	173/674 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly  7493 SSTPRPVTLEIAVPPVTSETTTNVPIGSTGGQVTGQTTATPSEVRTTIGVEESTLPSRSTDRTTP 7557
            :|.|||       ||..::.....|:..:..:..|:  .:||:.|:......:...|...|...|
Mouse    92 ASAPRP-------PPAPADGADPAPVEESEARPDGE--GSPSKGRSASARRPAAAASADRDDRGP 147

  Fly  7558 SESPETPTTLPSDFTTRPHSDQTTESTRDVPTTRPFEASTPSPASLETTVPSVTLETTTNVPIGS 7622
               |.:...|.|:|          |..|..|.         .|.|.:...|..     .||....
Mouse   148 ---PTSVAALRSNF----------EKIRKGPA---------QPGSADAEKPFY-----VNVEFHH 185

  Fly  7623 TGGQVTGQTTATPSEVRTTIGVEESTLPSRSTDRTTPSESPETPTTLPSDFTTRPH-SDQTTEST 7686
            ..|.|..........: :::|.:...:..:.:.::......|.|         ||| ..:::||:
Mouse   186 ERGLVKVNDKEVSDRI-SSLGSQAMQMERKKSQQSAGQGLGEAP---------RPHYRGRSSESS 240

  Fly  7687 RDVPTTRPFEASTPRPVTLETAVPSVTSETTTNVPIGSTVTSETTTNVPIGSTGGQVAGQTTAPP 7751
            ..:  ...:|.:...|..|:   .::.:....|.|....:..:...::.:|  |..|.|:..:|.
Mouse   241 CGL--DGDYEDAELNPRFLK---DNLINANGGNRPPWPPLEYQPYQSIYVG--GMMVEGEGKSPL 298

  Fly  7752 SEVRTTIRVEES-TLPSRSADRTTPSESPETPTTLPSDFTTRPHSEQTTESTRDVPTTRPFEAST 7815
            ...::|...|:. |.|.||.
Mouse   299 LRSQSTSEQEKRLTWPRRSY--------------------------------------------- 318

  Fly  7816 PSPASLETTVPSVTSETTTNVPIGSTGGQLTEQSTSSPSEVRTTIRV--EESTLPSRSTDRTFPS 7878
             ||.|.|.:....|.:.::|..:.|:....:...:|..|...||.|:  ::|..||:::.::|.|
Mouse   319 -SPRSFEDSGGGYTPDCSSNENLTSSEEDFSSGQSSRVSPSPTTYRMFRDKSRSPSQNSQQSFDS 382

  Fly  7879 ESPEKPTTLPSDFTTRPHLE-QTTESTRDVLTTRPFETSTPSPVSLETTVPSVTSETSTNVP--I 7940
            .||      |:....:.|.: |...|...::..|  :|....|...::|... .:::|...|  .
Mouse   383 SSP------PTPQCQKRHRQCQVVVSEATIVGVR--KTGQIWPSDGDSTFQG-EADSSFGTPPGY 438

  Fly  7941 GSTGGQVTEQTTAPPSVRTTETIVKSTHPAVSPDTTIPSEIPATRVPLESTTRLYTDQTIPPGST 8005
            |....|..||......:           |.:       .:.|::...|.|..|    .::..|:.
Mouse   439 GCAADQAEEQRRHQDGL-----------PYI-------DDSPSSSPHLSSKGR----GSLASGAL 481

  Fly  8006 DRTTSSERPDE----------STRLTSEE------------------STETTRPVPTVSPRDALE 8042
            |.|..||...|          |..|.|||                  :..|::||.|....:.:.
Mouse   482 DPTKVSELDLEKGLEMRKWVLSGILASEETYLSHLEALLLPMKPLKAAATTSQPVLTSQQIETIF 546

  Fly  8043 TTVTSLITETTKTTSGGTPRGQVTERTTKSVSELTTGRSSDVVTERTMPSNISSTTTVFN----- 8102
            ..|..|.....:...|..||.|......: |.:|....:|.:...|....|.........
Mouse   547 FKVPELYEIHKEFYDGLFPRVQQWSHQQR-VGDLFQKLASQLGVYRAFVDNYGVAMETAEKCCQA 610

  Fly  8103 NSE--PVSDNLPTTISITVTDSPT 8124
            |::  .:|:||....:..|.||.|
Mouse   611 NAQFAEISENLRARSNKDVKDSTT 634

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpy	NP_001260032.1	EGF_3	137..166	CDD:289699
		EGF_CA	212..247	CDD:238011
		EGF_CA	255..>286	CDD:214542
		EGF_CA	298..331	CDD:238011
		EGF_CA	338..373	CDD:238011
		EGF_CA	413..456	CDD:238011
		EGF_CA	457..490	CDD:238011
		EGF_CA	497..>529	CDD:214542
		EGF_CA	580..>612	CDD:214542
		EGF_3	676..702	CDD:289699
		EGF_CA	1022..1056	CDD:214542
		EGF_CA	2227..2260	CDD:238011
		EGF_CA	2393..>2422	CDD:214542
		DUF4758	4088..4282	CDD:292572
		DUF4696	4127..4678	CDD:292395
		DUF4758	4275..4448	CDD:292572
		DUF4758	4377..4574	CDD:292572
		DUF4758	4581..4754	CDD:292572
		DUF4758	4683..4847	CDD:292572
		DUF4758	4785..4964	CDD:292572
		DUF4696	4841..5385	CDD:292395
		DUF4758	4887..5098	CDD:292572
		DUF4758	5193..5371	CDD:292572
		DUF4758	5294..5487	CDD:292572
		DUF4758	5445..5650	CDD:292572
		DUF4758	5700..5877	CDD:292572
		DUF4696	5756..6396	CDD:292395
		DUF4758	5802..5979	CDD:292572
		DUF4758	5964..6171	CDD:292572
		DUF4758	6181..6360	CDD:292572
		DUF4696	6339..6999	CDD:292395
		DUF4758	6662..6839	CDD:292572
		DUF4758	6764..6941	CDD:292572
		DUF4758	6866..7045	CDD:292572
		DUF4758	6968..7179	CDD:292572
		DUF4696	7024..7569	CDD:292395	16/75 (21%)
		DUF4758	7172..7383	CDD:292572
		DUF4696	7330..7964	CDD:292395	85/477 (18%)
		DUF4758	7400..7587	CDD:292572	20/93 (22%)
		DUF4758	7538..7707	CDD:292572	28/169 (17%)
		DUF4758	7798..7979	CDD:292572	34/185 (18%)
		DUF4758	7946..8126	CDD:292572	42/214 (20%)
		YppG	18767..>18832	CDD:290883
		Med25_SD1	18795..18955	CDD:288132
		MISS	19026..19258	CDD:292450
		ZP	22576..22811	CDD:214579
		Zona_pellucida	<22714..22810	CDD:278526
Bcr	NP_001074881.1	Kinase. /evidence=ECO:0000250\|UniProtKB:P11274	1..428		79/443 (18%)
		Bcr-Abl_Oligo	3..75	CDD:286168
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	67..173		23/111 (21%)
		Binding to ABL SH2-domain. /evidence=ECO:0000250	198..387		43/257 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	201..249		8/59 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	295..396		28/152 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	412..481		15/91 (16%)
		RhoGEF	501..689	CDD:279015	28/135 (21%)
		PH-like	683..876	CDD:302622
		C2_ABR	912..1032	CDD:176068
		RhoGAP_Bcr	1051..1251	CDD:239852
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910