DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpy and CENPE

DIOPT Version :9

Sequence 1:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster
Sequence 2:	NP_001804.2	Gene:	CENPE / 1062	HGNCID:	1856	Length:	2701	Species:	Homo sapiens

Alignment Length:	1271	Identity:	202/1271 - (15%)
Similarity:	411/1271 - (32%)	Gaps:	277/1271 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly  3963 ETTTDFINVKYTVMQLANQTEMRTRF-TDIEAE-----NETTGPYTTTTESYKTTKQLSSNPETE 4021
            |..|.:..::..:....:|.|.:.:. .|:|.|     ||.|  ..|:....|..|.|..|.|.|
Human   657 ELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEIT--KLTSLIDGKVPKDLLCNLELE 719

  Fly  4022 TPTTLPSRPTTRPFTDQTTEFTSEIPTITPMEGSTPTPSHLETTVASITSESTTREVYTIKPFDR 4086
            ...|...:...:. .::......|:..::.::.   .||.:|.....|..:|....:.|.:. |:
Human   720 GKITDLQKELNKE-VEENEALREEVILLSELKS---LPSEVERLRKEIQDKSEELHIITSEK-DK 779

  Fly  4087 STPTPVSPDTTVPSITFET-TTNIPIGTTRG--QVTEQ------TTSSPSEKRTTIRVEESTLPS 4142
            .....|..::.|..:..|. .|...:.||:.  :.|:|      |.....|::..:.:||:...:
Human   780 LFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMN 844

  Fly  4143 RSTDRTTPSESPETPTILPSDSTTRTYSDQ-TTESTRDV-PTTRPFEASTPSPASLETTVPSVTL 4205
            :.....: .|:.:..:.|.:..|..:|..| ..|.||:| ......|.......:.::|:.:|..
Human   845 QEIVNLS-KEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVER 908

  Fly  4206 ETTTNDPIGSTGGQVTEQTTSSPSEVRTTIGLEESTLPSRSTDRTTPSESPETPTTLPSDFITRP 4270
            |.|.          :||:...:..||:        ||.....|.....||.:         |.|
Human   909 EKTL----------ITEKLQQTLEEVK--------TLTQEKDDLKQLQESLQ---------IER- 945

  Fly  4271 HSDQTTESTRDVPTTRPFEASTPSSASLETTVPSVTLETTTNVPIGSTGGQVTEQTTSSPSEVRT 4335
              ||......|.     ...:..:...|...:.|:.....|   |.:...:::|       ||..
Human   946 --DQLKSDIHDT-----VNMNIDTQEQLRNALESLKQHQET---INTLKSKISE-------EVSR 993

  Fly  4336 TIRVEESTLPSR--------SADRTTPSESPETPTTLPSDFTTRPHSEQTTESTRDV-------- 4384
            .:.:||:|..::        ..|:....|:..|.|     .|......:..|..|.:
Human   994 NLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQT-----LTADVKDNEIIEQQRKIFSLIQEKN 1053

  Fly  4385 PTTRPFEASTPSPASLETTVP---SVTLETTTNVPIGSTGGQVTGQTTSSPSEVRTTIRVEESTL 4446
            ...:..|:.......|:|.:.   .:|:|....:.:  .|.::..|......|....|:.|...
Human  1054 ELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRL--LGDELKKQQEIVAQEKNHAIKKEGEL- 1115

  Fly  4447 PSRSADRTTPSESPETPTTLPSDFITRPHSEKTTESTRDVPTTRPFEASTPSSASLETTVPSVTL 4511
             ||:.||....|                  ||..|.::.:...:....:.....|
Human  1116 -SRTCDRLAEVE------------------EKLKEKSQQLQEKQQQLLNVQEEMS---------- 1151

  Fly  4512 ETTTNVPIGSTGGQVTEQTTSSPSEVRTTIRVEESTLPSRSADR----TTLSESPETPTTLPSDF 4572
                          ..::..:....::..::.:|.||.....:|    ..|:|:.|...::..:.
Human  1152 --------------EMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKER 1202

  Fly  4573 TIRPHSEQTTESTRDVPTTRPFEASTPSPASLETTVPSVTSETTTNVPIGSTGGQVTGQTTAPPS 4637
            .:....:::.|:.||               .|...:..:               :.||..|  ..
Human  1203 KVLKELQKSFETERD---------------HLRGYIREI---------------EATGLQT--KE 1235

  Fly  4638 EFRTT-IRVEESTLPSRSTDRTTPSESPETPTILPSDSTTRTYSDQTTESTRDVPTTRPFEASTP 4701
            |.:.. |.::|.   ..:.|....|.|.:|..|:.:....:::    |:...::|.....:...|
Human  1236 ELKIAHIHLKEH---QETIDELRRSVSEKTAQIINTQDLEKSH----TKLQEEIPVLHEEQELLP 1293

  Fly  4702 SPASLETTVPSVTLETTTNVPIGSTGGQVTEQTTSSPSEVRTTIRVEESTLPSRSADRTTPSESP 4766
            :...:     |.|.||...:.:      :|||:|:..|.....|.:|...|
Human  1294 NVKEV-----SETQETMNELEL------LTEQSTTKDSTTLARIEMERLRL-------------- 1333

  Fly  4767 ETPTTLPSDFITRPHSEKTTESTRDVPTTRPFEASTPSSASLETTVPSVTLETTTNVPIGSTGGQ 4831
                           :||..||..::      ::.|....:|:|...::.::          ..|
Human  1334 ---------------NEKFQESQEEI------KSLTKERDNLKTIKEALEVK----------HDQ 1367

  Fly  4832 VTEQTTSSPSEVRTTIRVEESTLPSRSADRTTPSESPETPTTLPSDF---------------ITR 4881
            :.|....:.::::.:...:|.:|..:..|..|.....|.....|.|.               :..
Human  1368 LKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQE 1432

  Fly  4882 PHSEKTTESTRDVPTTRPFEASTPSSASLETTVPSVT---LETTTNVPIGSTGGQVTEQTTSSPS 4943
            .|.|..:.:.......|..|.....|..|:..:..:.   |||...:.:.....:..|:|.   :
Human  1433 SHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETI---N 1494

  Fly  4944 EVRTTIRVEESTLPSRSTDRTTPSESPETPTTLPSDFTTRPHSEQTTESTRDVPTTRPFEASTPS 5008
            |:|..:..:|:.:.:........::..:.......:...:.:.:|.:|....|...:.|:....:
Human  1495 ELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKA 1559

  Fly  5009 PASLETTVPSVTLETTTNVPIGSTGGQVTEQTTSSPSEVRTTIRVEESTLPSRSADRTTP-SESP 5072
            ..|...::.|..||.|..:.......|:..:.......|:..:::|...|...:.:.... .||.
Human  1560 KDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQ 1624

  Fly  5073 ETPTTLPSDFITRTYSDQTTESTRDVPTTR-PFEASTPSPASLETTVPSVTSETTTNVPIGSTGG 5136
            |.    ...|:..|..::|.|...::...: .||....:..::||....:|.....|:
Human  1625 EK----EYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENL------- 1678

  Fly  5137 QVTGQTTAPPSEFRT---TIRVEESTLPSRSTDRTT 5169
            :.....|....:.|:   |::||...|.....:..|
Human  1679 EEMRSVTKERDDLRSVEETLKVERDQLKENLRETIT 1714

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpy	NP_001260032.1	EGF_3	137..166	CDD:289699
		EGF_CA	212..247	CDD:238011
		EGF_CA	255..>286	CDD:214542
		EGF_CA	298..331	CDD:238011
		EGF_CA	338..373	CDD:238011
		EGF_CA	413..456	CDD:238011
		EGF_CA	457..490	CDD:238011
		EGF_CA	497..>529	CDD:214542
		EGF_CA	580..>612	CDD:214542
		EGF_3	676..702	CDD:289699
		EGF_CA	1022..1056	CDD:214542
		EGF_CA	2227..2260	CDD:238011
		EGF_CA	2393..>2422	CDD:214542
		DUF4758	4088..4282	CDD:292572	39/204 (19%)
		DUF4696	4127..4678	CDD:292395	89/576 (15%)
		DUF4758	4275..4448	CDD:292572	28/191 (15%)
		DUF4758	4377..4574	CDD:292572	28/211 (13%)
		DUF4758	4581..4754	CDD:292572	30/173 (17%)
		DUF4758	4683..4847	CDD:292572	24/163 (15%)
		DUF4758	4785..4964	CDD:292572	28/196 (14%)
		DUF4696	4841..5385	CDD:292395	54/352 (15%)
		DUF4758	4887..5098	CDD:292572	32/214 (15%)
		DUF4758	5193..5371	CDD:292572
		DUF4758	5294..5487	CDD:292572
		DUF4758	5445..5650	CDD:292572
		DUF4758	5700..5877	CDD:292572
		DUF4696	5756..6396	CDD:292395
		DUF4758	5802..5979	CDD:292572
		DUF4758	5964..6171	CDD:292572
		DUF4758	6181..6360	CDD:292572
		DUF4696	6339..6999	CDD:292395
		DUF4758	6662..6839	CDD:292572
		DUF4758	6764..6941	CDD:292572
		DUF4758	6866..7045	CDD:292572
		DUF4758	6968..7179	CDD:292572
		DUF4696	7024..7569	CDD:292395
		DUF4758	7172..7383	CDD:292572
		DUF4696	7330..7964	CDD:292395
		DUF4758	7400..7587	CDD:292572
		DUF4758	7538..7707	CDD:292572
		DUF4758	7798..7979	CDD:292572
		DUF4758	7946..8126	CDD:292572
		YppG	18767..>18832	CDD:290883
		Med25_SD1	18795..18955	CDD:288132
		MISS	19026..19258	CDD:292450
		ZP	22576..22811	CDD:214579
		Zona_pellucida	<22714..22810	CDD:278526
CENPE	NP_001804.2	KISc	6..336	CDD:214526
		KISc_CENP_E	6..329	CDD:276825
		SbcC	345..915	CDD:223496	52/275 (19%)
		Mplasa_alph_rch	660..1366	CDD:275316	145/904 (16%)
		NUDE_C	828..>911	CDD:282704	16/83 (19%)
		Mplasa_alph_rch	1151..1951	CDD:275316	101/697 (14%)
		Smc	1676..2482	CDD:224117	8/46 (17%)
		Kinetochore-binding domain	2126..2476
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2355..2376
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2508..2533
		Globular autoinhibitory domain. /evidence=ECO:0000250	2510..2698
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2588..2701
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910