DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment dpy and otog

DIOPT Version :9

Sequence 1:NP_001260032.1 Gene:dpy / 318824 FlyBaseID:FBgn0053196 Length:22949 Species:Drosophila melanogaster
Sequence 2:XP_021333298.1 Gene:otog / 103911405 ZFINID:ZDB-GENE-120228-1 Length:3214 Species:Danio rerio


Alignment Length:2692 Identity:585/2692 - (21%)
Similarity:813/2692 - (30%) Gaps:1088/2692 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly  2900 GQCFNPCLQPQACGQNAECVMQNHLKQCHCPEGFTGDSAKECVRVP-------VAC--------- 2948
            |:|.:|||      ....||   |...|:|.  ....:...|..||       :.|         
Zfish   153 GECASPCL------NGGRCV---HPDSCNCT--LYQAAGTRCQTVPNLGFEREMTCRSWGQYNYE 206

  Fly  2949 ---------DGECGPGYT----CRDSMCLPV---CHNDLECASNE-KC----------------- 2979
                     .|:|  .||    |.|:....|   .|||.||:|:. .|                 
Zfish   207 TFDGLYYYFPGKC--SYTLLRDCEDNARSSVHIQVHNDPECSSSPYSCTRSISLFLPWEGEIRLQ 269

  Fly  2980 -----LKGSCMLTCRVDNDC-----------------------------------FLGHVCLHNK 3004
                 .||..:|.....:|.                                   |:||.|  ..
Zfish   270 HFSVTFKGQSVLLPHHIHDVELERISDYIVVSQPHVFTLAWQGLTSSVYIKMSPEFVGHTC--GL 332

  Fly  3005 C-VYGCHVDDDCSASESCRNDKCVNPC---------------LEN--PCG----------PNAAC 3041
            | .:.....||...|..    ||...|               |::  .|.          .|:..
Zfish   333 CGNFNADTQDDLKTSYG----KCCFICCICYIVSILFCQVFSLDSIVVCSGVFTQDLAMFGNSWA 393

  Fly  3042 SVSNHRASCSCLESMVPNPTPQVGCVRSPPLECRENRDCGNGLACFESVCRPLCADD-------- 3098
            ......|.|:.:.|:.|:|     |....|          :.|...|.||..|..:.        
Zfish   394 EEEPELARCTVVPSLYPSP-----CATLDP----------HVLLKVEEVCSTLLREPFQSCHEFV 443

  Fly  3099 ------AGCLTNERCQQG-----VCKPLCRHDNECGHGELCL--GLNCVPGCRSDQGCPPELSCV 3150
                  |.| :|:.|..|     ||:....:...|.|.:..|  .....|.|..|  ||.||  :
Zfish   444 SPYSYMASC-SNDLCLSGPNGAVVCQVFTEYARACAHADHPLHDWRTHFPVCNVD--CPDEL--L 503

  Fly  3151 GQQCVDPCADPTACGTNAHCQTIDHRKQCL----CPEGLDGNANVACKVPRIACGRN-------- 3203
            .::|:..|  |..|.....|  ||.:.|||    ||:.|.....|..|.....|..:        
Zfish   504 FRECITCC--PMHCKIEQMC--IDSKLQCLDGCYCPDDLIFEDGVCVKASDCPCEHHGMLYPSGH 564

  Fly  3204 ---EDCQSNQLCYAG-------SCQGKCRNDQNCL---ADER--CMRGTCRTV------------ 3241
               ||| :|..|:.|       :|.|:|....:..   .|.|  ....||:.|            
Zfish   565 IIQEDC-NNCTCFGGIWNCTEHNCPGECSVTGDMFFQSFDGRVYTFPATCQYVLAKSRNSGKFTV 628

  Fly  3242 --------CNTDEACAQGQICENRMCQTGCRTDLSCA-----------------TDE-------- 3273
                    .|.|.||.|.   .|.:.....||:::.:                 :|:        
Zfish   629 TIQNAPCGANLDGACIQS---VNLVVNEDPRTEITMSHSGEVFLASQFRISLPYSDDMFQIQELS 690

  Fly  3274 -ACVNKKCQNPC---------------------RTPGQC----GQCADCLVVNHGVQCQCPAAFM 3312
             ..|..|.....                     .|.|.|    |...|..:...|:....|..|.
Zfish   691 SMFVQVKLSQGLWLQYNWKEFRLYLQLEEQWRDNTLGLCGTFNGNIQDDFLAPSGMIESTPFLFG 755

  Fly  3313 GDGLTGCQLPPERCHPDCE-CD---ENGAYCAPKCS-RTED--CACGQ---------QCARGKCR 3361
            ..........|....|..: ||   :..:|...||. .|::  .||.:         ||....| 
Zfish   756 NAWRVSSACVPRPSLPQLDPCDTHQQAASYAVEKCDVLTQEVFSACHEYVSPVGFQLQCRADVC- 819

  Fly  3362 NKCGPKRQCTV----GQLCERGA-----------CIAGCKSN---GDC--AADQSCVNGKCSDPC 3406
             |||....|::    .:.|.|..           |...|.|.   |.|  |..:.|:......||
Zfish   820 -KCGALCLCSILAHYARTCRRHGVIIEFRSHLPECAVSCPSTMEYGVCVSACQRRCLFLSLPQPC 883

  Fly  3407 ANEKACGRNALCTVSEHRMLCYCPDGYEGEPSKECVQFECRVDTDCDSNKRCDQGKCRNPCLEYG 3471
            .:|...|             |.||:|         ..|.....| |.....|       ||...|
Zfish   884 GDECEEG-------------CVCPEG---------TYFNMHTHT-CVPRNEC-------PCSFLG 918

  Fly  3472 ACGTNAQCRVVGRKAQCSCPPDFFGNPTSECRPLEGGCSS----KPCGENSKCTEVPGGYECACM 3532
            |..:.....:.....|. |..   |...|:...:|..|.:    :.||..              :
Zfish   919 ADYSPGDVIITSSGVQI-CQD---GKLVSQTSIIETLCPAGQFYEDCGNR--------------V 965

  Fly  3533 DGCIGDAHQGCLCGGPLVNACRDQPCG---LNAACHVLENNQAECYCPED-FPNGDAYVQCYLTT 3593
            ||  ..|.:|..|         :|.|.   ||..|...|.....|.||.. ..:||   :|:   
Zfish   966 DG--PSASKGLAC---------EQTCETYLLNLTCSTHEPCVPGCVCPAGLLKHGD---ECF--- 1013

  Fly  3594 PKQDCRTLGCEVGGCVRQGYEY-------------VCQQDTEQCYSDTDCPSEKSCLQGHCSDPC 3645
                 :...|.   |:.:|.||             |||..|.|| ....|||           .|
Zfish  1014 -----KPRACP---CLWKGKEYYPGDKVSSPCHQCVCQHGTFQC-EFRPCPS-----------MC 1058

  Fly  3646 TMR----------------GVC-------GLNA----------------LCKTVLH--------- 3662
            |..                |||       .|:|                :|:..||         
Zfish  1059 TAYGDRHYRTFDGFLFDYIGVCKVYLVKSSLDAMLTVTAENVDCFESGVICRKSLHISVGRSFIV 1123

  Fly  3663 ------RPRCSCPSCHIGRPE----------------------------IECKSDPKCVAEDT-- 3691
                  ||.   ||..|.|..                            |..::.|:.....|  
Zfish  1124 FDDDTGRPN---PSSVIDRQRAYIWQAGYYTIVHLLGEDLTVLWDRKTTIHIQAGPRWQGRLTGL 1185

  Fly  3692 ----DPKTKEQI--PCSTDSECPE-------TLQCGQYGQCTDPCN-NPLFICESNKKCETRRHQ 3742
                |.||..::  |.:.||..|:       ..:|........||| |||....:.::|.....:
Zfish  1186 CGNFDQKTANEMRTPENIDSSTPQEFGNSWTAAECVNSPDIRHPCNLNPLREPFAKRQCGILLSE 1250

  Fly  3743 PVCICK-----SGFIVNEYGELTCAPDKRECYRDDDC---ASNMACSDGKC---------RNPCI 3790
            ...:|.     :.|.:|      |..|...|.|..||   .:::|....:|         |:|.|
Zfish  1251 VFQVCHPVVDVTWFYMN------CLVDTCGCNRGGDCECFCTSVAAYAHRCCQKGIPIDWRSPSI 1309

  Fly  3791 VP---------LG-----------RAAICAENKSCEVQNHKPVCICMRD------------CQPS 3823
            .|         ||           |..:.|.||:..:...|      ||            ..|.
Zfish  1310 CPYDCEYYNKALGKGPLKLLTYRERGTLLAANKTSGLVFPK------RDLTSVDENLVLFMMTPG 1368

  Fly  3824 IS-----------------------------------------------ICLRDAGCPASQACRK 3841
            ||                                               :..||...|...:...
Zfish  1369 ISKARPHDSSLVSFEAADRPNYFLKAEQGSQLRLGKWEDTPAFWDAATFVLHRDTWIPGFDSLES 1433

  Fly  3842 L---------------------------------------------------KCVDPCEFATCAP 3855
            |                                                   .||.|| |.||:.
Zfish  1434 LARPGFFLHFMLSRLQLQKYSHSDRYRRATLFKLTGAIPHYPMGPRCQWRFESCVRPC-FRTCSD 1497

  Fly  3856 NS-----------PCIVEDHKPICKFCPAGFIADAKNGCQKAKPGGNCTSNTDCSQAHQCGSSGK 3909
            .|           .|:.:        ||:..:.|                    ...|:|.|...
Zfish  1498 PSGLSCTSILKIEGCLPQ--------CPSHMVLD--------------------EVTHRCVSLED 1534

  Fly  3910 CIDPCLTSCAGGVKCVVSAHRVTICTCPATLTNNTDSNCTSTDITVGTTTQRIETTTDFINVKYT 3974
            ||.|.:..                   |.||.:.|.|   ||..:...|:.....:|..|:    
Zfish  1535 CIRPPVVP-------------------PFTLPSTTIS---STPFSEDYTSSIPAVSTALIS---- 1573

  Fly  3975 VMQLANQTEMRTRFTDIEAENETTGPYTTTTESYKTTKQLSSNPETETPTTLPSRPTTRPFTDQT 4039
                                       |..:||..||...:..|.||.|||.|.||         
Zfish  1574 ---------------------------TAVSESSATTTPTTHMPTTEKPTTSPIRP--------- 1602

  Fly  4040 TEFTSEIPTITPMEGS-TPTPSHLETTVA-SITSESTTREVYTIKPFDRSTPTPVSPDTTVP--- 4099
             |....|.|:|....| :|..|...||.| ||||..|:.......|...|.|..|:..|:.|   
Zfish  1603 -EVVEVITTLTTSSSSWSPLASTERTTKAPSITSSPTSSTTLYTSPVSISAPVSVTSTTSSPTES 1666

  Fly  4100 SITFETTTNIPIGTTRGQVTEQTTSSPSEKRTTIRVEESTLPSRSTDRTTPSESPETPTILPSDS 4164
            |..|..||.||...:...|...|:||...:.:|:.|    ||..::...|.:.||......|..|
Zfish  1667 STPFTRTTTIPSQPSSSPVLRSTSSSEQTRVSTLPV----LPVSTSMGPTEATSPTVKVSSPLTS 1727

  Fly  4165 TTRTYSDQTTESTRDVPTTRPFEASTPSPASLETTVPSVTLETTTNDPIGSTGGQVTEQTTSSPS 4229
            .|.              |.|..||.||:.   :||.|:|:....:..|..|.  .:|:.|:.|  
Zfish  1728 ITE--------------TARVSEAITPTE---KTTTPTVSSSGISQFPAESI--SMTKFTSLS-- 1771

  Fly  4230 EVRTTIGLEESTLPSRSTDRTTPSESPETPTTLPSDFITRPHSDQTTESTRDVPTTRPFEASTPS 4294
              .||..||..|  |.:|....||.|.:|                               ..||.
Zfish  1772 --TTTPVLEWRT--SGTTAEMAPSTSLDT-------------------------------LKTPE 1801

  Fly  4295 SASLETTVPSVTLETTTNVPIGSTGGQVTEQTTSSPSEVRTTIRVEESTLPSRSADRTTPSESPE 4359
            |.| ||..||.    ||.:|             :||::.:.:  ....|:.|.|:...||   |.
Zfish  1802 STS-ETQKPSY----TTTIP-------------TSPTDTKAS--TTYITVKSTSSAFATP---PA 1843

  Fly  4360 TPTTL--PSDFTTRPHSEQTTESTRDVPTTRPFEASTPSPASLETT-------VPSVTLETTTNV 4415
            |.|||  ||..:.:|.:.:||.|           .||.:|.||.|.       ||:.|...||..
Zfish  1844 TQTTLYTPSTTSEQPETSKTTVS-----------FSTAAPTSLTTVSSQAPAFVPTKTTAKTTYQ 1897

  Fly  4416 PIGSTGGQVTGQTTSSPSE-----VRTTIRVEESTLPSRSADRTTPSESP-ETPTTLPSDFITRP 4474
            |.........|.||....:     ::||....|.|..|:.:.||  :|:| .|.||:|..:  .|
Zfish  1898 PTSVIYTYPDGPTTDRALQTDWRVIQTTSTQLELTETSQISVRT--AETPLTTYTTMPPTW--AP 1958

  Fly  4475 HSEKTTESTRDVPTTRPFEASTPS-SASLETTVPSVTLETTTNVPIGSTGGQVTEQTTSSP---- 4534
            ..|.||..|..:..|....:..|| |.:|..|..|.:|.:||::        .||:.::||    
Zfish  1959 TEETTTLLTSQMSPTDKTTSRVPSTSTTLGYTESSWSLSSTTSL--------YTEKVSTSPIHPH 2015

  Fly  4535 --SEVRTTIRVEE------STLPSRSADRTTLSESPETPTTLPSDFTIRPHSEQTTESTRDVPTT 4591
              :.|.||..:.|      |.|.|..:..|::|::|          ||      |||:.  |.:.
Zfish  2016 YTTTVATTPALSEISSASPSILTSSVSQTTSISQTP----------TI------TTETA--VTSE 2062

  Fly  4592 RPFEASTPSPAS-LETTVPSVTSETTTNVPIGSTGGQVTGQ----TTAPPSEFRTTIRVEESTLP 4651
            :|...||.:... :.||..|.|:..|.::...:|...:...    |||..::..|.:....||:|
Zfish  2063 KPLLTSTAAEEEVVSTTQTSTTTHLTIHLDTETTKASLDTDRAVITTAATAQTPTLVHETSSTIP 2127

  Fly  4652 S----RSTDRTTPSESPETPTILPSDSTTRTYSDQTTESTRDVPTTRPFEASTPSPASLETTVPS 4712
            |    |.|.|.||        :|    |:|...|...::.:||.||     |...|..:|||   
Zfish  2128 STMAPRLTTRITP--------VL----TSRVGVDTIRQTPQDVATT-----SISPPTRIETT--- 2172

  Fly  4713 VTLETTTNVPIGSTGGQVTEQTTSSPSEVRTTIRVEESTLPSRSADRTTPSESPETPTTLPSDFI 4777
            :|..||.:          ||:.||    |.|||    .:..:.|:..|||  .||.|.      .
Zfish  2173 MTTSTTVS----------TEKETS----VSTTI----PSTAAASSTLTTP--IPEIPE------F 2211

  Fly  4778 TRPHSEKT--TESTRDVPTTRPFEASTPSSASLETT-VPSVTLETT--TNVPIGSTGGQVTEQTT 4837
            |...:|.|  :.||..:|:   |..:||:.....|| |.||..:||  |::|..|.      .||
Zfish  2212 TSGFTEYTAVSGSTTTLPS---FTGTTPTRTGTTTTPVASVLTQTTISTHLPTSSI------VTT 2267

  Fly  4838 SSPSEVRTTIRVEESTLPSRSADRTTPSESPETPTTLPSDFITRPHSEKTTESTRDVPTTRPFEA 4902
            |||           .|..|.|.:.....|||.. ||||                   ||  |..|
Zfish  2268 SSP-----------ITSSSTSTEHHLVDESPMV-TTLP-------------------PT--PDTA 2299

  Fly  4903 STPSSASLETTVPSVTLETTTNVPIGSTGGQVTEQTTSSPSEVRTTIRVEESTLPSRSTDRTTPS 4967
            .|..|.|::|::| .|:||.         ..:|.||.:.|                    :||..
Zfish  2300 QTTRSTSVKTSLP-YTIETE---------HWMTSQTQAVP--------------------KTTAH 2334

  Fly  4968 ESPETPTTLPSDFTTRPHSEQTTESTR 4994
            |        ||...|.|:||...|.|:
Zfish  2335 E--------PSRVCTAPYSEVVDECTK 2353

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dpyNP_001260032.1 EGF_3 137..166 CDD:289699
EGF_CA 212..247 CDD:238011
EGF_CA 255..>286 CDD:214542
EGF_CA 298..331 CDD:238011
EGF_CA 338..373 CDD:238011
EGF_CA 413..456 CDD:238011
EGF_CA 457..490 CDD:238011
EGF_CA 497..>529 CDD:214542
EGF_CA 580..>612 CDD:214542
EGF_3 676..702 CDD:289699
EGF_CA 1022..1056 CDD:214542
EGF_CA 2227..2260 CDD:238011
EGF_CA 2393..>2422 CDD:214542
DUF4758 4088..4282 CDD:292572 50/196 (26%)
DUF4696 4127..4678 CDD:292395 152/587 (26%)
DUF4758 4275..4448 CDD:292572 48/186 (26%)
DUF4758 4377..4574 CDD:292572 60/222 (27%)
DUF4758 4581..4754 CDD:292572 50/181 (28%)
DUF4758 4683..4847 CDD:292572 51/168 (30%)
DUF4758 4785..4964 CDD:292572 48/183 (26%)
DUF4696 4841..5385 CDD:292395 37/154 (24%)
DUF4758 4887..5098 CDD:292572 27/108 (25%)
DUF4758 5193..5371 CDD:292572
DUF4758 5294..5487 CDD:292572
DUF4758 5445..5650 CDD:292572
DUF4758 5700..5877 CDD:292572
DUF4696 5756..6396 CDD:292395
DUF4758 5802..5979 CDD:292572
DUF4758 5964..6171 CDD:292572
DUF4758 6181..6360 CDD:292572
DUF4696 6339..6999 CDD:292395
DUF4758 6662..6839 CDD:292572
DUF4758 6764..6941 CDD:292572
DUF4758 6866..7045 CDD:292572
DUF4758 6968..7179 CDD:292572
DUF4696 7024..7569 CDD:292395
DUF4758 7172..7383 CDD:292572
DUF4696 7330..7964 CDD:292395
DUF4758 7400..7587 CDD:292572
DUF4758 7538..7707 CDD:292572
DUF4758 7798..7979 CDD:292572
DUF4758 7946..8126 CDD:292572
YppG 18767..>18832 CDD:290883
Med25_SD1 18795..18955 CDD:288132
MISS 19026..19258 CDD:292450
ZP 22576..22811 CDD:214579
Zona_pellucida <22714..22810 CDD:278526
otogXP_021333298.1 VWD 197..350 CDD:306577 27/160 (17%)
C8 427..490 CDD:312319 13/63 (21%)
TIL 498..551 CDD:307783 19/58 (33%)
VWC 553..>589 CDD:327433 8/36 (22%)
VWD 580..745 CDD:214566 24/167 (14%)
C8 789..849 CDD:312319 14/61 (23%)
TIL 857..912 CDD:307783 17/77 (22%)
TIL 952..1018 CDD:307783 20/101 (20%)
VWD 1058..1202 CDD:306577 23/146 (16%)
C8 1237..1311 CDD:214843 15/79 (19%)
Fascin <1376..1443 CDD:329072 4/66 (6%)
Herpes_BLLF1 <1749..2213 CDD:330317 162/612 (26%)
VWD 2392..2558 CDD:214566
C8 2594..2663 CDD:214843
TIL 2666..2725 CDD:307783
CT 3131..3213 CDD:214482
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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