DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpy and wu:fb80c09

DIOPT Version :9

Sequence 1:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster
Sequence 2:	XP_017208913.2	Gene:	wu:fb80c09 / 103909608	ZFINID:	ZDB-GENE-030131-1776	Length:	946	Species:	Danio rerio

Alignment Length:	702	Identity:	124/702 - (17%)
Similarity:	214/702 - (30%)	Gaps:	154/702 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly  6993 TTVPSVTLETTTNVPIG-STGGQV------TEQTTSSPSEVRTTIRVEESTLPSRSTDRTTPSES 7050
            ||..:|..||...||:. .:.||:      ||..:.|.|        .::..|:|...:...:.:
Zfish    82 TTADAVDSETEQLVPLKLKSEGQLFNCCDGTEDISQSTS--------NDTPAPNRPICQPCGTGA 138

  Fly  7051 PETPTTLPSDFTTRPHSDQTTE--SSRDVPTTQPFEASTPRPV-----TLQTAVLPVTSETTTNV 7108
            .....:|..|..|   |::.:|  |..:..:.:.||......:     .|:..||.|...:....
Zfish   139 QIEDASLEEDEAT---SEEKSEELSQEEAASEEKFEEEAGAELDASDEVLEEEVLDVKEMSDVEA 200

  Fly  7109 PIGSTGGQVTEQTTSSPSEVRTTIRVEESTLPSRSTDRTTPSESPETPTTLPSDFTTRPHSDQTT 7173
            .:|.   :..|:.....|:      :.:.::.....|..|..|:.|...:...:.......:||.
Zfish   201 QLGE---ESLEEGVEEDSQ------ISDESVGEEEEDLQTEDEAGEVKLSQNEEQVIVEEVEQTE 256

  Fly  7174 ESSRDVPTTQPFESSTPRPVTLETAVPPVTSETTTNVPIGSTGGQVTEQTTPSPSEVRTTIRIEE 7238
            |...:...|:.....|...|..|........|......:..|..:|.|:.....:|...   :||
Zfish   257 EEKEEDIQTEDEAFQTEDEVVEEEESLQTEEEVVEEEEVLQTEEEVVEEEEALQTEEEI---VEE 318

  Fly  7239 STFPSRSTDRTTPSESPETPTTLPSDFTTRPHSDQTTESTRDVPTTRPFESSTPRPVTLEIAVPP 7303
            ...       .|..|..|....|    .|...:.|..|           .|...:.|..|..|..
Zfish   319 EAL-------MTKEEVVEEEEVL----QTEDEAGQGEE-----------HSQADKEVVEEEEVLQ 361

  Fly  7304 VTSETTTNVAIGSTGGQVTEQT-TSSPSEVRTTIRVEESTLPSRSTDRTTPSESPETPTTLPSDF 7367
            :..|......:..|..:..|.: ...|.|....:..||.||       |....:||  ......|
Zfish   362 IQDEADVEEEVSQTEEEAAEDSQIEQPLEQVEEVAEEEDTL-------TEEEGAPE--VVEERQF 417

  Fly  7368 TTRPHSDQTTESTRDVPTTRPFEASTPSPASLETTVPSVTLETTTSVPMGSTGGQVTGQTTAPPS 7432
            ...|.:.:....|         |...|:     |.|....:|....|....|..|.|.|..||..
Zfish   418 VEEPKAAEELVET---------EVEEPA-----TDVVEEVVELAQEVNEEPTPEQTTDQEDAPAP 468

  Fly  7433 EVRTTIRVEESTLPSRSTDRTPPSESPETPTTLPSDFTTRPHSDQTTESSRDVPTTQPFESSTPR 7497
            .....:.:....:|:..........:|..|.|     ..|.|.::|...:...|:.:..::....
Zfish   469 AEEAKVELVSEDVPATKASAKVEKNAPSGPVT-----RDRSHIEETLRLATAEPSREYVDALKKL 528

  Fly  7498 PVTLEIAVPPV---------------TSETTTNVPIGSTGGQVTGQTTATPSEVRTTIGVEESTL 7547
            ......|:.|:               .:|.|:...:...|....|::    |.:...:|:|||
Zfish   529 QEVYNTAIKPLEKAYKYNELRQHEVSDAEITSKPMVLFLGPWSVGKS----SMINYLLGLEES-- 587

  Fly  7548 PSRSTDRTTPSESPETPTTLPSDFTTRPHSDQTTESTRDVPTTRPFEASTPSPASLETTVPSVTL 7612
               |....|.:|    |||  |::|...|..:                                |
Zfish   588 ---SQQLYTGAE----PTT--SEYTVLMHGKK--------------------------------L 611

  Fly  7613 ETTTNVPIGSTGGQ-VTGQTTATPSEVRTTIGVEESTLPSRSTDRTTPSESP 7663
            .|...:.:.:.|.: .|.........:...:|:|   :|.:..:|.|..::|
Zfish   612 RTVEGIVMAADGSRSFTALEKFGQGFLEKLVGIE---MPHKLLERVTFVDTP 660

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpy	NP_001260032.1	EGF_3	137..166	CDD:289699
		EGF_CA	212..247	CDD:238011
		EGF_CA	255..>286	CDD:214542
		EGF_CA	298..331	CDD:238011
		EGF_CA	338..373	CDD:238011
		EGF_CA	413..456	CDD:238011
		EGF_CA	457..490	CDD:238011
		EGF_CA	497..>529	CDD:214542
		EGF_CA	580..>612	CDD:214542
		EGF_3	676..702	CDD:289699
		EGF_CA	1022..1056	CDD:214542
		EGF_CA	2227..2260	CDD:238011
		EGF_CA	2393..>2422	CDD:214542
		DUF4758	4088..4282	CDD:292572
		DUF4696	4127..4678	CDD:292395
		DUF4758	4275..4448	CDD:292572
		DUF4758	4377..4574	CDD:292572
		DUF4758	4581..4754	CDD:292572
		DUF4758	4683..4847	CDD:292572
		DUF4758	4785..4964	CDD:292572
		DUF4696	4841..5385	CDD:292395
		DUF4758	4887..5098	CDD:292572
		DUF4758	5193..5371	CDD:292572
		DUF4758	5294..5487	CDD:292572
		DUF4758	5445..5650	CDD:292572
		DUF4758	5700..5877	CDD:292572
		DUF4696	5756..6396	CDD:292395
		DUF4758	5802..5979	CDD:292572
		DUF4758	5964..6171	CDD:292572
		DUF4758	6181..6360	CDD:292572
		DUF4696	6339..6999	CDD:292395	2/5 (40%)
		DUF4758	6662..6839	CDD:292572
		DUF4758	6764..6941	CDD:292572
		DUF4758	6866..7045	CDD:292572	15/58 (26%)
		DUF4758	6968..7179	CDD:292572	37/199 (19%)
		DUF4696	7024..7569	CDD:292395	99/567 (17%)
		DUF4758	7172..7383	CDD:292572	39/211 (18%)
		DUF4696	7330..7964	CDD:292395	61/350 (17%)
		DUF4758	7400..7587	CDD:292572	38/201 (19%)
		DUF4758	7538..7707	CDD:292572	23/127 (18%)
		DUF4758	7798..7979	CDD:292572
		DUF4758	7946..8126	CDD:292572
		YppG	18767..>18832	CDD:290883
		Med25_SD1	18795..18955	CDD:288132
		MISS	19026..19258	CDD:292450
		ZP	22576..22811	CDD:214579
		Zona_pellucida	<22714..22810	CDD:278526
wu:fb80c09	XP_017208913.2	RNase_E_G	<408..501	CDD:331378	21/113 (19%)
		EHD_N	528..558	CDD:318972	2/29 (7%)
		EHD	563..804	CDD:206740	26/148 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910