DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpy and LOC101882968

DIOPT Version :9

Sequence 1:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster
Sequence 2:	XP_021335855.1	Gene:	LOC101882968 / 101882968	-ID:	-	Length:	997	Species:	Danio rerio

Alignment Length:	712	Identity:	153/712 - (21%)
Similarity:	215/712 - (30%)	Gaps:	284/712 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly  6580 PASLETTVPSVTSETTTNVP----IGSTGGQV--TGQTTAPPSEVRTTIRVEESTLPSRSTDRTT 6638
            |.|:.....::.:.|..|||    ..:|.|.|  |..||..|:  .||:   .:|:|
Zfish   198 PDSVNGNYRNLKNTTNVNVPGRWAFNATSGSVYNTSNTTVTPA--TTTL---STTVP-------- 249

  Fly  6639 PSESPETPTILPSDFTTRPHSDQTTESTRDVPTTR-----PFEAS---TPRPVTLETAVPSVTLE 6695
                |||.|     |||.|   .....|...|.|.     ||.::   |.:.|..:.::.||.|.
Zfish   250 ----PETTT-----FTTVP---PVVAMTSAQPWTAPAIFYPFGSAVGDTEQTVYNDESLYSVGLS 302

  Fly  6696 TTTNVPIGSTGGQV----TGQTTATPSEVRTTIRVEESTLPSRSTDRTTPSESPETPTTLPSD-- 6754
            |.... .|.|...:    ||..|.|.:.|.|:   ..:..|.|..|        :....|.||
Zfish   303 TPFTF-FGHTYTMLYLMHTGLLTFTITSVATS---GPNYTPIRGND--------DFIAALWSDID 355

  Fly  6755 ------------FTTRPHSDQTTESTRDVPTTRPFEA-----------STPSPASL--------- 6787
                        :|.....|:.|:......:|..|.|           |.|:||.|
Zfish   356 DYYNIGLFSYQQYTNGSVLDRATQDINQYFSTTNFSASWVFVVTWKYGSQPNPAILFQAVLISGS 420

  Fly  6788 -ET---------------------TVPSVTS--------------ETTTNVPI------GSTGGQ 6810
             |:                     |:.|::.              :.||||.:      .:|.|.
Zfish   421 GESFFLLNYGDCAVLYEAVEAGFDTINSISKFIIPDSVNGNYRNLKNTTNVNVSGRWAFNATSGS 485

  Fly  6811 VTEQTTSSPSEVRTTIGLEESTLPSRSTDRTSPSESPETPTTLPSDFITRPHSDQTTESTRDVPT 6875
            |    .|:|:   ||:                      ||.|             ||.:|..:.|
Zfish   486 V----YSAPN---TTV----------------------TPAT-------------TTSTTTTITT 508

  Fly  6876 T-RPFEA-STPSPASLETTVPSVTSETTTNVPIGSTGGQVTEQTTSSPSEVRTTI---------- 6928
            | .|..| |:..|    .|.|:|.      .|.||..|......|.|.|:|...:
Zfish   509 TVAPVVAMSSAQP----WTAPAVF------YPFGSAVGDTEYSETGSESQVSVALSTPFTFFGHT 563

  Fly  6929 ---------GLEESTLPSRSTDRTSPSESPETPTTLPSDFITRPHSD------------QTT--- 6969
                     ||...|:.|.|....||....|       |||....:|            |.|
Zfish   564 YNSLYVIYNGLLTFTITSTSGPYYSPFRGRE-------DFIAALWNDFDDYLTGVISYQQYTNGS 621

  Fly  6970 ---ESTRDV-----PTTRPFEASTPSSASLETTV---PSVTLETTTNVPIGSTGG---------- 7013
               .:|:|:     |..  |:||....|:....:   |.:..:.   |.|..:||
Zfish   622 VLNRATQDINQHFSPVN--FQASWVFVATWRYNLQPNPQILFQV---VLISGSGGSFFLMNYGDC 681

  Fly  7014 ----QVTE---QTTSS------PSEVRTTIRVEESTLPSRSTDRTTPSESPETPTTLPSDFTTRP 7065
                :|||   .|.:|      |..:....|..:||     |:...|..........|:.|  .|
Zfish   682 ASLYEVTEAGFDTINSISKFVIPDSINGNYRNLKST-----TNVNVPGRWAFNAWAAPAIF--YP 739

  Fly  7066 HSDQTTESSRDV---PTTQPFEASTP---------RPVTLQTAVLPVTSETTTNVPIGSTGG 7115
            ......::...|   ..:.|...|||         ....:.|.||..|...|.||.|...||
Zfish   740 FGSTVGDTEHHVNYDENSYPVALSTPFTFFGHTYNSLYAIYTGVLSFTISPTLNVDINPFGG 801

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpy	NP_001260032.1	EGF_3	137..166	CDD:289699
		EGF_CA	212..247	CDD:238011
		EGF_CA	255..>286	CDD:214542
		EGF_CA	298..331	CDD:238011
		EGF_CA	338..373	CDD:238011
		EGF_CA	413..456	CDD:238011
		EGF_CA	457..490	CDD:238011
		EGF_CA	497..>529	CDD:214542
		EGF_CA	580..>612	CDD:214542
		EGF_3	676..702	CDD:289699
		EGF_CA	1022..1056	CDD:214542
		EGF_CA	2227..2260	CDD:238011
		EGF_CA	2393..>2422	CDD:214542
		DUF4758	4088..4282	CDD:292572
		DUF4696	4127..4678	CDD:292395
		DUF4758	4275..4448	CDD:292572
		DUF4758	4377..4574	CDD:292572
		DUF4758	4581..4754	CDD:292572
		DUF4758	4683..4847	CDD:292572
		DUF4758	4785..4964	CDD:292572
		DUF4696	4841..5385	CDD:292395
		DUF4758	4887..5098	CDD:292572
		DUF4758	5193..5371	CDD:292572
		DUF4758	5294..5487	CDD:292572
		DUF4758	5445..5650	CDD:292572
		DUF4758	5700..5877	CDD:292572
		DUF4696	5756..6396	CDD:292395
		DUF4758	5802..5979	CDD:292572
		DUF4758	5964..6171	CDD:292572
		DUF4758	6181..6360	CDD:292572
		DUF4696	6339..6999	CDD:292395	120/559 (21%)
		DUF4758	6662..6839	CDD:292572	50/264 (19%)
		DUF4758	6764..6941	CDD:292572	51/259 (20%)
		DUF4758	6866..7045	CDD:292572	56/248 (23%)
		DUF4758	6968..7179	CDD:292572	42/197 (21%)
		DUF4696	7024..7569	CDD:292395	23/104 (22%)
		DUF4758	7172..7383	CDD:292572
		DUF4696	7330..7964	CDD:292395
		DUF4758	7400..7587	CDD:292572
		DUF4758	7538..7707	CDD:292572
		DUF4758	7798..7979	CDD:292572
		DUF4758	7946..8126	CDD:292572
		YppG	18767..>18832	CDD:290883
		Med25_SD1	18795..18955	CDD:288132
		MISS	19026..19258	CDD:292450
		ZP	22576..22811	CDD:214579
		Zona_pellucida	<22714..22810	CDD:278526
LOC101882968	XP_021335855.1	NIDO	95..222	CDD:322035	6/23 (26%)
		NIDO	351..479	CDD:322035	20/127 (16%)
		NIDO	601..728	CDD:322035	26/136 (19%)
		NIDO	808..937	CDD:322035
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910