DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpy and LOC101732121

DIOPT Version :9

Sequence 1:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster
Sequence 2:	XP_031752740.1	Gene:	LOC101732121 / 101732121	-ID:	-	Length:	659	Species:	Xenopus tropicalis

Alignment Length:	676	Identity:	161/676 - (23%)
Similarity:	248/676 - (36%)	Gaps:	189/676 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly  3719 CTDPCNNPLFICESNKKCETRRHQPVCICKSGFIVNEY--------GELTCAPDKRECYRDDDCA 3775
            |:|        |.||..|.|:.:...|.||:||..|..        ..::|.|...:..:
Frog    90 CSD--------CNSNAVCTTKTNYVTCSCKTGFAGNGINCTEIVFCSSVSCCPPGYQWNQ----- 141

  Fly  3776 SNMACSD-GKCRNPCIVPLGRAAICAENKSCEVQNHKPVCICMRDCQPSISICLRDAGCPASQAC 3839
            .::|||| .:|.||  :.|...|.|.......:            |..::.:......||....|
Frog   142 GSLACSDINECLNP--LNLCYPATCTNKVGSYI------------CGSTVGMSCGGIYCPNDLDC 192

  Fly  3840 RKLK----CVDPCEFATCAPNSPCIVEDHK----PICKF------CPAGFIADAKNGCQKAKPGG 3890
            ..:.    |.|||:::.....:..:...:.    |..:|      ...||         |.|.|
Frog   193 IYINGTPTCADPCKYSKQLDGASRLYTINSTGVFPTDQFNIGWFHYTPGF---------KMKEG- 247

  Fly  3891 NCTSNTDCSQAHQCGSSG-----------------KCIDPCLTSCAGGVKCVVSAHRVTICTCP- 3937
                   |....:|||:|                 ..|...:|.|..|....|.|       |.
Frog   248 -------CIGPLKCGSAGPFTLSSHPNIGDGIKLKSTIVNTVTGCIPGSSIPVKA-------CDG 298

  Fly  3938 -------ATLTNNTDSNCTSTDITVGTTTQRIETTTDFINVKYTVMQLANQTEMRTRFTDIEAEN 3995
                   .||.    |....:||:..|||....|||
Frog   299 FYVYKFLGTLW----SEVYCSDISAATTTLTTTTTT----------------------------- 330

  Fly  3996 ETTGPYTTT--TESYKTTKQLSSNPETETPTTLPSRPTTRPFTDQTTEFTSEIPTITPMEGSTPT 4058
             ||.|.|||  |.|..||...::.|.|.|.||.|:..||.  |..||..|:..||.|.   :|.|
Frog   331 -TTSPATTTTPTTSTTTTTPTTTAPTTTTTTTAPTTTTTT--TAPTTTTTTTAPTTTT---TTTT 389

  Fly  4059 PSHLETTVASITSESTTREVYTIKPFDRSTPTPVSPDTTVPSITFETTTNIP-IGTTRGQVTEQT 4122
            |:....|..|.|:.:||..:.|..|...|:.||.:..:       :.:.::| :.::.|::....
Frog   390 PTTTTITTPSTTTPTTTMPITTTTPLFISSATPATSHS-------QFSASLPLLSSSTGELNIPA 447

  Fly  4123 TSSPSEKRTTIRVEES----TLPSRSTDRTTPSESPETP---------TI-----LPSDSTTRTY 4169
            ||:||.  ||::...:    |..|.:.:.:|.|.||:||         ||     .|.::.|.|:
Frog   448 TSNPSP--TTLKSSTATTNFTTQSHNLNTSTTSSSPKTPCANITSQPITIPVSQPYPEENITITH 510

  Fly  4170 SDQTTESTRDVPTTRPFEASTPSPASLETTVPSVTLETTTNDPIGSTGGQVTEQTTS-SPSEVRT 4233
            ....:..|..:.:.:..:..|.|....|||:.::.::|.|.:.|      .|:.||| ||:.:..
Frog   511 VSSRSILTVRIVSQKTEDIDTKSLEINETTIVNIEVKTITPNNI------YTKTTTSVSPTSILI 569

  Fly  4234 TI-GLEESTLPSRSTDRTTPSE--SPETPTTLPSDFITRPHSDQTTESTRDVPTTRPFEASTPSS 4295
            .: |....:|..|.....|.||  :|.|....|..:.::|...:||..|......|   .|:..|
Frog   570 HVAGSAPESLADRPDTIVTSSETTTPNTEIFQPDSYCSQPAQTKTTTETSSTAGNR---CSSIVS 631

  Fly  4296 ASLETTVPSVTLETTTN--VPIGSTG 4319
            |:..||:      |||.  :.:|..|
Frog   632 ATTTTTI------TTTEEIIVLGPRG 651

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpy	NP_001260032.1	EGF_3	137..166	CDD:289699
		EGF_CA	212..247	CDD:238011
		EGF_CA	255..>286	CDD:214542
		EGF_CA	298..331	CDD:238011
		EGF_CA	338..373	CDD:238011
		EGF_CA	413..456	CDD:238011
		EGF_CA	457..490	CDD:238011
		EGF_CA	497..>529	CDD:214542
		EGF_CA	580..>612	CDD:214542
		EGF_3	676..702	CDD:289699
		EGF_CA	1022..1056	CDD:214542
		EGF_CA	2227..2260	CDD:238011
		EGF_CA	2393..>2422	CDD:214542
		DUF4758	4088..4282	CDD:292572	51/216 (24%)
		DUF4696	4127..4678	CDD:292395	55/217 (25%)
		DUF4758	4275..4448	CDD:292572	14/47 (30%)
		DUF4758	4377..4574	CDD:292572
		DUF4758	4581..4754	CDD:292572
		DUF4758	4683..4847	CDD:292572
		DUF4758	4785..4964	CDD:292572
		DUF4696	4841..5385	CDD:292395
		DUF4758	4887..5098	CDD:292572
		DUF4758	5193..5371	CDD:292572
		DUF4758	5294..5487	CDD:292572
		DUF4758	5445..5650	CDD:292572
		DUF4758	5700..5877	CDD:292572
		DUF4696	5756..6396	CDD:292395
		DUF4758	5802..5979	CDD:292572
		DUF4758	5964..6171	CDD:292572
		DUF4758	6181..6360	CDD:292572
		DUF4696	6339..6999	CDD:292395
		DUF4758	6662..6839	CDD:292572
		DUF4758	6764..6941	CDD:292572
		DUF4758	6866..7045	CDD:292572
		DUF4758	6968..7179	CDD:292572
		DUF4696	7024..7569	CDD:292395
		DUF4758	7172..7383	CDD:292572
		DUF4696	7330..7964	CDD:292395
		DUF4758	7400..7587	CDD:292572
		DUF4758	7538..7707	CDD:292572
		DUF4758	7798..7979	CDD:292572
		DUF4758	7946..8126	CDD:292572
		YppG	18767..>18832	CDD:290883
		Med25_SD1	18795..18955	CDD:288132
		MISS	19026..19258	CDD:292450
		ZP	22576..22811	CDD:214579
		Zona_pellucida	<22714..22810	CDD:278526
LOC101732121	XP_031752740.1	EGF_CA	92..121	CDD:419698	12/36 (33%)
LOC101732121	XP_031752740.1	EGF_CA	148..181	CDD:214542	8/46 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910