DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpy and ldlr

DIOPT Version :9

Sequence 1:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster
Sequence 2:	XP_002942891.1	Gene:	ldlr / 100495826	XenbaseID:	XB-GENE-962372	Length:	894	Species:	Xenopus tropicalis

Alignment Length:	575	Identity:	134/575 - (23%)
Similarity:	174/575 - (30%)	Gaps:	239/575 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly  1901 GTCHPSAICEVTPEGPVCKCPPLFVGDAKSGGCRPDGQCPNGDADC-PANTICAGGVCQNPCDNA 1964
            |.||.|||.||.      ||.            |.:.||  ||..| |...||.|
Frog    16 GLCHVSAISEVR------KCD------------RSEFQC--GDGKCIPYKWICDG---------- 50

  Fly  1965 CGSNAECKVINRKPVCSCPLRFQPISDTAKDGCARTISKCLTD-VDCGGALCYNGQC---RIACR 2025
               :||||               ..||.:.:.|  .:..|..| ..|||.|   .:|   ...|.
Frog    51 ---SAECK---------------DGSDESPETC--KVVTCGADHFSCGGRL---NRCIPLLWKCD 92

  Fly  2026 NSQDCSDGESCLKNVCVVACLDHSQCASGLACVEGHCTIGCRSNKECKQDQ-SCIENKCLNPCQS 2089
            ...||.:|..                       |..||     .|.|..|| :|...||::
Frog    93 GQTDCENGSD-----------------------ENDCT-----RKVCADDQFTCRSGKCIS---- 125

  Fly  2090 ANSCGPNALCSIDQHHSQCSCPEGFEGNPTPEQGCVRVPAPCL--ASNQCPSGHMCIGNQCNLPC 2152
                 .:.:|..|     ..|.:|     :.|..|   |||..  |..||....:||....
Frog   126 -----LDFVCDED-----LDCDDG-----SDESYC---PAPTCNPAMFQCKDKGICIPKLW---- 168

  Fly  2153 TKTASCAVGERCYQQVCRKVCYTSNNCLAGEICNSDRTCQPGCD-----------SDADCPPTEL 2206
                                           .|:.|..|:.|.|           :|..|.|.|.
Frog   169 -------------------------------ACDGDPDCEDGSDEQHCEGREPIKTDKPCSPLEF 202

  Fly  2207 -CLTGKC-----KCATGFIGTPFGC---SDIDECTEQPC-------------HASARCENLPGTY 2249
             |.:|:|     ||..|     :.|   ||..:|.:..|             |.|.:|:.   .|
Frog   203 HCGSGECIHMSWKCDGG-----YDCKDKSDEKDCVKPTCRPDEFQCNDGTCIHGSRQCDR---EY 259

  Fly  2250 RCVCPEGTVGDGYSQPGCSQPRQCHKPDDCANNLACIHGKCTDPCLHTVCGINANCQSEGHEALC 2314
            .|       .|...:.||....:|..||    ...|..|:|.  .:..||....:|:....|.:.
Frog   260 DC-------KDLSDEEGCVNVTKCEGPD----VFKCRSGECI--TMDKVCNKKRDCRDWSDEPIK 311

  Fly  2315 SCPAGFLGDPNDTGVGCFKVECIDHVDCAGDRACDAETNRCIKPCDLTSCGKGNCQVRDHKATCA 2379
            .|                           |:..|......|...|:....|          ..|.
Frog   312 EC---------------------------GENECMRNNGGCAHICNDLKIG----------YECL 339

  Fly  2380 CYEGYQLVNDV-CEDINECLSQPCHSTAFCNNLPGSYSCQCPEGLIGDPLQAGCR 2433
            |.|||:||:.. ||||||| ..|...:..|.||.|.|.|:|.||...||:.|.|:
Frog   340 CNEGYRLVDKKRCEDINEC-ENPNTCSQICINLDGGYKCECREGYQMDPVTASCK 393

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpy	NP_001260032.1	EGF_3	137..166	CDD:289699
		EGF_CA	212..247	CDD:238011
		EGF_CA	255..>286	CDD:214542
		EGF_CA	298..331	CDD:238011
		EGF_CA	338..373	CDD:238011
		EGF_CA	413..456	CDD:238011
		EGF_CA	457..490	CDD:238011
		EGF_CA	497..>529	CDD:214542
		EGF_CA	580..>612	CDD:214542
		EGF_3	676..702	CDD:289699
		EGF_CA	1022..1056	CDD:214542
		EGF_CA	2227..2260	CDD:238011	8/45 (18%)
		EGF_CA	2393..>2422	CDD:214542	13/28 (46%)
		DUF4758	4088..4282	CDD:292572
		DUF4696	4127..4678	CDD:292395
		DUF4758	4275..4448	CDD:292572
		DUF4758	4377..4574	CDD:292572
		DUF4758	4581..4754	CDD:292572
		DUF4758	4683..4847	CDD:292572
		DUF4758	4785..4964	CDD:292572
		DUF4696	4841..5385	CDD:292395
		DUF4758	4887..5098	CDD:292572
		DUF4758	5193..5371	CDD:292572
		DUF4758	5294..5487	CDD:292572
		DUF4758	5445..5650	CDD:292572
		DUF4758	5700..5877	CDD:292572
		DUF4696	5756..6396	CDD:292395
		DUF4758	5802..5979	CDD:292572
		DUF4758	5964..6171	CDD:292572
		DUF4758	6181..6360	CDD:292572
		DUF4696	6339..6999	CDD:292395
		DUF4758	6662..6839	CDD:292572
		DUF4758	6764..6941	CDD:292572
		DUF4758	6866..7045	CDD:292572
		DUF4758	6968..7179	CDD:292572
		DUF4696	7024..7569	CDD:292395
		DUF4758	7172..7383	CDD:292572
		DUF4696	7330..7964	CDD:292395
		DUF4758	7400..7587	CDD:292572
		DUF4758	7538..7707	CDD:292572
		DUF4758	7798..7979	CDD:292572
		DUF4758	7946..8126	CDD:292572
		YppG	18767..>18832	CDD:290883
		Med25_SD1	18795..18955	CDD:288132
		MISS	19026..19258	CDD:292450
		ZP	22576..22811	CDD:214579
		Zona_pellucida	<22714..22810	CDD:278526
ldlr	XP_002942891.1	Ldl_recept_a	27..60	CDD:365841	17/80 (21%)
		Ldl_recept_a	68..106	CDD:365841	12/63 (19%)
		LDLa	111..145	CDD:238060	11/52 (21%)
		Ldl_recept_a	149..185	CDD:365841	10/70 (14%)
		Ldl_recept_a	195..231	CDD:365841	12/40 (30%)
		Ldl_recept_a	235..270	CDD:365841	7/44 (16%)
		LDLa	278..308	CDD:381805	8/35 (23%)
		FXa_inhibition	318..352	CDD:373209	11/43 (26%)
		EGF_CA	354..384	CDD:214542	15/30 (50%)
		LY	419..457	CDD:214531
		Ldl_recept_b	439..482	CDD:278487
		Ldl_recept_b	486..525	CDD:278487
		Ldl_recept_b	529..569	CDD:278487
		LY	555..595	CDD:214531
		Ldl_recept_b	616..655	CDD:278487
		FXa_inhibition	674..711	CDD:373209
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910