DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment dpy and notch3

DIOPT Version :9

Sequence 1:NP_001260032.1 Gene:dpy / 318824 FlyBaseID:FBgn0053196 Length:22949 Species:Drosophila melanogaster
Sequence 2:XP_017948007.1 Gene:notch3 / 100494244 XenbaseID:XB-GENE-6450008 Length:2413 Species:Xenopus tropicalis


Alignment Length:2069 Identity:526/2069 - (25%)
Similarity:732/2069 - (35%) Gaps:640/2069 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   107 GAC----LNGVCHCNDGYGGCNCVDKDENECKQRPCDVFAHCT-NTLGSFTCTCFPGYRGNGFHC 166
            |.|    :..|.....|..|..|:|      ..|||.....|| .:.|...|.|...:.|     
 Frog     5 GLCELIWVTAVLLSRKGIHGFQCLD------SYRPCQNGGRCTMYSNGEAACVCLTSWIG----- 58

  Fly   167 EDIDECQDPAIAARCVENAECCNL----PAHFLCKCKDGYEGDGEVLCTDVDEC-RNPENCGPNA 226
             ::.:.:||.:.:.|:....|.:.    ...:.|.|..|:.|..   |:.:|.| .||  |...|
 Frog    59 -ELCQFKDPCVPSPCINGGACQSSIRGGTVQYECSCAKGFRGQD---CSLIDACASNP--CENGA 117

  Fly   227 LCTNTPGNYTCSCPDGYVGNNPYREGCQ-DVDECSYPNVCGPGAICTNLEGSYRCDCPPGYDGDG 290
            .|||..|.|.|:||.||.|.:     |: |:|||..|.:|..|..|.|..||:||.||.||.|. 
 Frog   118 RCTNWNGRYNCTCPPGYQGRS-----CRVDIDECRTPGLCQNGGQCVNTPGSFRCRCPSGYTGQ- 176

  Fly   291 RSESGCVDQDECARTPCGRNADCLNT-DGSFRCLCPDGYSGDPMNGCE-DVDECATNNPCGLGAE 353
            ..|:..|   .||.:.|.....|..| |.:::|.|..|:.|.   .|| :||:| ..:.|..|..
 Frog   177 FCEAIYV---PCAPSQCQNGGTCRQTGDLTYQCACLPGFEGP---NCEINVDDC-PGHKCMNGGT 234

  Fly   354 CVNLGGSFQCRCPSGFVLEHDPHADQLPQPLNTQQLGYGPGATDIAPYQRTSGAGLACL-DIDEC 417
            ||:...::.|:|                                 ||    ...|..|. |:|||
 Frog   235 CVDGVNTYNCQC---------------------------------AP----EWTGQYCTEDVDEC 262

  Fly   418 N-QPDGVAKCGTNAKCINFPGSYRCLCPSGFQGQGYLHC-ENINECQDNPCGENAICTDTVGSFV 480
            . ||:.   |.....|.|..|.:.|:|.:|:.|:.   | |||::|....|...|.|.|.|.||.
 Frog   263 QLQPNA---CHNGGTCFNTQGGHTCVCVNGWTGES---CSENIDDCATAVCFNGATCHDRVASFY 321

  Fly   481 CTCKPDYTGDPFRGCVDIDECTALDKPCGQHAVCE-NTVPGYN-CKCPQGYDGKPDPKVACEQVD 543
            |.|....||   ..|...|.|  :..||.:.|:|: |.|.|.. |.||.|:.|.     ||:|  
 Frog   322 CECPMGKTG---LLCHLEDAC--VSNPCHKDAMCDTNPVNGRAICTCPPGFTGG-----ACDQ-- 374

  Fly   544 VNILCSSNFDCTNNAECIENQCFCLDGFEPIGSSCVDIDECRTHAEVCGPHAQCLNTPGSYGCEC 608
                                                |:|||...|..|....:|:||.||:.|:|
 Frog   375 ------------------------------------DVDECSIGANPCEHFGRCVNTQGSFQCQC 403

  Fly   609 EAGYVGSPPRMACK---QPCEDVRCGAHAYCKPDQNEAYCVCEDGWTYNPSDVAAGC-VDIDECD 669
            ..||.|  ||  |:   ..|....|...|.|.....|..|:|..|:|      ...| ::|:||:
 Frog   404 GRGYTG--PR--CETDVNECLSTPCQNDATCLDRIGEFTCICMAGFT------GTFCELNINECE 458

  Fly   670 VMHGPFGSCGQNATCTNSAGGFTCACPPGFSGDPHSKC-VDVDECRTGASKCGAGAECVNVPGGG 733
                 ...|.....|.:...||||:||.||:|   |.| :|:|||  .::.|..||:||:.| .|
 Frog   459 -----SSPCVNGGVCKDVVNGFTCSCPAGFTG---SMCQIDIDEC--ASTPCKNGAKCVDRP-NG 512

  Fly   734 YTCRCPGNTIADPDPSVRCVPIVSCSANEDCPGNSICDATKRCLCPEPNIGNDCR-HPCEALNCG 797
            |.|||.                      |...| .:||.         || :||. .||.     
 Frog   513 YECRCA----------------------EGFEG-PLCDR---------NI-DDCSPDPCH----- 539

  Fly   798 AHAQCMLANGQAQCLCAPGYTGNSALAGGC-NDIDECRANPCAEKAICSNTAGGYLCQCPGGSSG 861
             |.:|........|.|.|||||..     | |.|:||.:|||.....|.:....|||.|..|:||
 Frog   540 -HGKCRDGIASFTCTCEPGYTGYR-----CENQINECHSNPCMHGGKCIDLVNKYLCYCQQGTSG 598

  Fly   862 DPYREGCITSKTVGCSD------ANPCATGETCVQDSYTGNSVCICRQGYERNSENGQCQ-DVDE 919
                        |.|..      :|||..|| | :|...... |:|:.|:    ....|. :|..
 Frog   599 ------------VHCEHNYDDCASNPCDYGE-C-RDGINRYD-CVCKAGF----TGPLCNIEVSP 644

  Fly   920 CSVQRGKPACGLNALCKNLPGSYECRCPQGHNGNPFIMCEICNTPECQCQSPYKLVGNSCVLSGC 984
            |:   ..| |.....|:.....:.|.||:|.....|    :||    ..|.|.|           
 Frog   645 CA---SNP-CRAGGTCQVTQNGFRCLCPEGRGTRDF----LCN----PTQDPDK----------- 686

  Fly   985 SSGQACPSG---AECISIAGGVSYCACPKGYQTQPDGSCVDVDECEERGAQLCA-----FGAQCV 1041
               :.||.|   ..|..::.|.| |.|..|:..:         .|:.||:.:|.     .|..|:
 Frog   687 ---ELCPPGCVHGVCRRLSDGYS-CDCKVGWTGR---------MCDRRGSDVCTPNPCQNGGNCI 738

  Fly  1042 NKPGSYSCHCPEGYQGDAYNGLCALAQRKCAADRECAANEKC---IQPGECVCPPPYFLDPQDNN 1103
            :..|...|.|.:|::|..    |.:...:||: ..|....||   |....|:|..||     ...
 Frog   739 DHQGVPICRCRDGFRGPT----CMIDIDECAS-APCLNGGKCMDGIAGYSCLCTLPY-----TGQ 793

  Fly  1104 KCKS---PCERFPCGINAKCTPS---DPPQCMCEAGFKGDPLLGCTDE-DECSHLPCAYGAYCVN 1161
            ||::   ||...||.....|:|:   :...|.|..|::|:.   |.|: |||:..||..|.:|.|
 Frog   794 KCETILDPCAPDPCHNGGICSPTPDYESHMCQCSPGWRGET---CDDDIDECARSPCKNGGFCTN 855

  Fly  1162 KKGGYQCVCPKDYTGDPYKSGCIFESGTPKSKCLSNDDCASNLACLEGSCVSPCSSLLCGSNAYC 1226
            .:|||.|.|...:.|...::..              :||..| .||.|..   |..   |.|::.
 Frog   856 MQGGYSCACLSGFNGQDCETDI--------------NDCNPN-PCLNGGA---CKD---GINSFA 899

  Fly  1227 ETEQHAGWCRCRVGYVKNGDGDCVSQCQDVICGDGALCIPTSEGPTCKCPQGQLGNPFPGGSCST 1291
                    |.|..|:..:...|.:::|....|.:||.|........|.|..|     :.|..|.|
 Frog   900 --------CSCIPGFTGSRCTDEINECLSNPCRNGATCKDYVNSYVCSCAPG-----YTGPICET 951

  Fly  1292 DQCSAARPCGERQICIN-GRCKERCEGVVCGIGATCDRNNGKCICEPNFVGNPDLICMPPIEQAK 1355
            :    .:.|.|.. |.| |.|   .:||          |:..|.|.|.|.|:.   |...:::..
 Frog   952 N----IQDCTESS-CFNGGTC---VDGV----------NSYTCRCRPGFTGSH---CQNEVDECA 995

  Fly  1356 CSPGCGENAHCEYGLGQSRCACNPGTFGNPYEGCGAQSKN---VCQPNSCGPNAECRAVGNHISC 1417
            ..| |...|.|..|:...||.|       ||...|||.:|   :|:.:.|.....|...|....|
 Frog   996 SRP-CQNGAMCVDGVESYRCIC-------PYGYTGAQCQNLVDLCRRSPCQNGGRCTQTGPSFRC 1052

  Fly  1418 LCPQGFSGN----PYIGCQDV----DECANKPCGLNAACLNRAGGFECLCLSGHAG----NPYSS 1470
            .||.|::|:    |.:.|:..    :..|::.|.....|:|......|:|..|:.|    ||.:.
 Frog  1053 ECPAGWAGSYCDVPRVSCEVAAARRNVRADQLCHSGGICMNAGSSHHCICRGGYTGSYCENPINQ 1117

  Fly  1471 CQPIESKFCQDANKCQ-------CNERVECPEGY----------SCQKGQCKNLCSQASCGPRAI 1518
            |.|..   |.:...|.       |    |||.||          .||...|:|       |...|
 Frog  1118 CDPDP---CHNGGACHSYLGGYVC----ECPSGYEGKNCEYDINECQSHPCQN-------GGTCI 1168

  Fly  1519 CDAGN--CICPMGYIGDPHDQVHGCSIRGQCGNDADCLHSEICFQLGKGLRKCVDACSKIQCGPN 1581
            ...|.  |.||.|.:|..      |.|     |:.||....|     .|..||::         |
 Frog  1169 DLIGRYICSCPPGTLGVL------CEI-----NEDDCSPLSI-----SGPPKCLN---------N 1208

  Fly  1582 ALCVSEDHRSSCICSDGFFGNPSNLQVGCQPERTVPEEEDKCKSD-QDCSRGYGCQASVNGIKEC 1645
            ..|:.:.....|.|..|:.|                   ::|:.| .:|..| .|.|  ...:.|
 Frog  1209 GTCIDKVGGYRCNCPPGYTG-------------------ERCEGDINECLSG-PCHA--QNTRHC 1251

  Fly  1646 INLCSNVVCGPNELCKINPAGHAICNCAESYVWNPVVSSCEKPSLPDCTSDANCPDASACRPDVL 1710
            :.|.::..|    :||   :|:....|      ..|:::||  |.|       |.:...|     
 Frog  1252 VQLANDYQC----VCK---SGYTGRRC------QSVMNTCE--SRP-------CQNGGVC----- 1289

  Fly  1711 GVLKCVAICDAFTCPANSVCVARQHQGRCDCLNGFVGNPNDRNGCQPAQKHHCRNHAECQESEAC 1775
                             ||.|.......|.|..||.|                   ..|:     
 Frog  1290 -----------------SVTVNTPLGYTCRCPLGFTG-------------------PSCE----- 1313

  Fly  1776 IKDESTQTLGCRP--ACDTVKCGPRAVCVTNNHQAQCQCPPGPFAGDPYDPFNGCQSVPCVYNHD 1838
                       ||  :|..:.|...:.|:......:|.||||.....|.:     .|.|      
 Frog  1314 -----------RPPLSCRELSCPSGSTCLPPPLGPRCICPPGVLCRTPNN-----SSAP------ 1356

  Fly  1839 CPPSQMCNRMTHTCFDVCDEESCGDNAICLAEDHRAVCQCPPGFKGDPLPEVACTKQGGCAAGTC 1903
             .|:.:          .|....|.:.|.|:...|....||                       .|
 Frog  1357 -TPAPL----------PCSNSPCRNGATCIPNIHFPYYQC-----------------------KC 1387

  Fly  1904 HPSAICEVTPEGPVCKC-PPLFVGDAKSGGCRPDGQCPNGDADCPANTICAGGVCQNPCD-NAC- 1965
            ||..|      ||.|.. .|..:....:.||.| ..||....|         |.|...|: .|| 
 Frog  1388 HPGMI------GPRCDIRTPRILTQTPAPGCTP-SHCPGKAGD---------GHCDRECNVAACK 1436

  Fly  1966 GSNAECKVINRKPVCSCPLRFQPISDTAKDGCARTISKCLTDVDCGGALCY--NGQCRIACRNSQ 2028
            ....:|.:....|..:||          :..|....:....|.:|..|.|.  |..||  .|..:
 Frog  1437 WDGGDCSLSVDDPWRNCP----------RQECRSLFNNSQCDKECTSADCLYDNFDCR--GREER 1489

  Fly  2029 DCSDGESCLKNVCVVACLDHSQCASGLACVEGHCTIGCRSNKECKQD-QSCIEN 2081
            .|:.       |....|:||..        :|.|..||.| :||..| ..|.:|
 Frog  1490 SCNP-------VYEKYCMDHYG--------DGRCDKGCNS-EECGWDGLDCAKN 1527

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dpyNP_001260032.1 EGF_3 137..166 CDD:289699 8/29 (28%)
EGF_CA 212..247 CDD:238011 17/35 (49%)
EGF_CA 255..>286 CDD:214542 15/30 (50%)
EGF_CA 298..331 CDD:238011 9/33 (27%)
EGF_CA 338..373 CDD:238011 9/34 (26%)
EGF_CA 413..456 CDD:238011 15/44 (34%)
EGF_CA 457..490 CDD:238011 13/32 (41%)
EGF_CA 497..>529 CDD:214542 12/33 (36%)
EGF_CA 580..>612 CDD:214542 13/31 (42%)
EGF_3 676..702 CDD:289699 10/25 (40%)
EGF_CA 1022..1056 CDD:214542 10/38 (26%)
EGF_CA 2227..2260 CDD:238011
EGF_CA 2393..>2422 CDD:214542
DUF4758 4088..4282 CDD:292572
DUF4696 4127..4678 CDD:292395
DUF4758 4275..4448 CDD:292572
DUF4758 4377..4574 CDD:292572
DUF4758 4581..4754 CDD:292572
DUF4758 4683..4847 CDD:292572
DUF4758 4785..4964 CDD:292572
DUF4696 4841..5385 CDD:292395
DUF4758 4887..5098 CDD:292572
DUF4758 5193..5371 CDD:292572
DUF4758 5294..5487 CDD:292572
DUF4758 5445..5650 CDD:292572
DUF4758 5700..5877 CDD:292572
DUF4696 5756..6396 CDD:292395
DUF4758 5802..5979 CDD:292572
DUF4758 5964..6171 CDD:292572
DUF4758 6181..6360 CDD:292572
DUF4696 6339..6999 CDD:292395
DUF4758 6662..6839 CDD:292572
DUF4758 6764..6941 CDD:292572
DUF4758 6866..7045 CDD:292572
DUF4758 6968..7179 CDD:292572
DUF4696 7024..7569 CDD:292395
DUF4758 7172..7383 CDD:292572
DUF4696 7330..7964 CDD:292395
DUF4758 7400..7587 CDD:292572
DUF4758 7538..7707 CDD:292572
DUF4758 7798..7979 CDD:292572
DUF4758 7946..8126 CDD:292572
YppG 18767..>18832 CDD:290883
Med25_SD1 18795..18955 CDD:288132
MISS 19026..19258 CDD:292450
ZP 22576..22811 CDD:214579
Zona_pellucida <22714..22810 CDD:278526
notch3XP_017948007.1 EGF_CA 105..139 CDD:238011 17/40 (43%)
EGF_CA 142..179 CDD:238011 18/37 (49%)
DSL <164..217 CDD:366627 20/59 (34%)
EGF_CA 220..256 CDD:238011 12/73 (16%)
EGF_CA 258..295 CDD:238011 14/42 (33%)
EGF_CA 298..333 CDD:238011 14/37 (38%)
EGF_CA 375..413 CDD:238011 18/41 (44%)
EGF_CA 415..451 CDD:238011 9/41 (22%)
EGF_CA 453..489 CDD:238011 15/43 (35%)
EGF_CA 491..526 CDD:238011 17/60 (28%)
EGF_CA 529..564 CDD:238011 15/46 (33%)
EGF_CA 567..602 CDD:238011 15/46 (33%)
EGF 726..756 CDD:333761 8/29 (28%)
EGF_CA 760..796 CDD:238011 11/41 (27%)
EGF_CA 838..874 CDD:238011 14/35 (40%)
EGF_CA 876..912 CDD:238011 12/64 (19%)
EGF_CA 915..950 CDD:238011 9/39 (23%)
EGF_CA 952..988 CDD:238011 14/56 (25%)
EGF_CA 991..1026 CDD:238011 13/42 (31%)
EGF_CA 1029..1063 CDD:238011 9/33 (27%)
EGF_CA 1115..1150 CDD:238011 10/41 (24%)
EGF_CA 1152..1188 CDD:238011 12/48 (25%)
EGF_CA 1190..1232 CDD:238011 13/74 (18%)
EGF_CA 1234..1272 CDD:238011 12/53 (23%)
EGF_CA 1276..1313 CDD:238011 14/86 (16%)
Notch 1410..1443 CDD:365847 11/42 (26%)
Notch 1451..1484 CDD:365847 8/42 (19%)
Notch 1498..1524 CDD:365847 11/34 (32%)
NOD 1531..1582 CDD:369091
NODP 1602..1655 CDD:369464
PHA03095 <1796..>2007 CDD:222980
ANK repeat 1805..1851 CDD:293786
ANK repeat 1853..1884 CDD:293786
ANK repeat 1887..1918 CDD:293786
ANK repeat 1920..1951 CDD:293786
Ank_2 1925..2017 CDD:372319
ANK repeat 1953..1984 CDD:293786
ANK repeat 1986..2017 CDD:293786
Ank_2 1991..>2047 CDD:393464
Med15 2116..>2410 CDD:312941
Atrophin-1 2278..>2412 CDD:367360
DUF3454 2335..2389 CDD:371809
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 45 1.000 Domainoid score I12014
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
22.000

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