DRSC/TRiP Functional Genomics Resources

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Protein Alignment dpy and celsr3

DIOPT Version :9

Sequence 1:NP_001260032.1 Gene:dpy / 318824 FlyBaseID:FBgn0053196 Length:22949 Species:Drosophila melanogaster
Sequence 2:XP_031757039.1 Gene:celsr3 / 100489102 XenbaseID:XB-GENE-852799 Length:3718 Species:Xenopus tropicalis


Alignment Length:2369 Identity:468/2369 - (19%)
Similarity:697/2369 - (29%) Gaps:864/2369 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly  7113 TGGQVTEQTTSSPSEVRTTIRVEESTLPSR--STDRTTPSESP----ETP--------------- 7156
            |.|..:.:..|:|:         |.|.|:.  :.:...||.:|    |.|               
 Frog   532 TEGSTSAEAISAPA---------EGTAPTSQPAAELNPPSFAPGVQHEPPEMEACSLYFPFNSTK 587

  Fly  7157 ----TTLP-SDFTTRPHSDQTT----ESSRDVPTTQPFESSTPRPVTLETAVPPVTSETTTNVPI 7212
                ||.| .|....|:.|.|:    :||:.: ...||.             ||:.:.     |.
 Frog   588 GCLKTTFPIKDLGKHPNIDLTSLLQLQSSKAM-QPDPFH-------------PPLRTH-----PQ 633

  Fly  7213 G----STGGQVTEQTTPSPSEVRTTIRIEESTFPSRSTD-RTTPSESPETPTTLPSDFTTRPHSD 7272
            |    |:|......:.|.....|...|  ...||..:.. :...::.|.||.     .|......
 Frog   634 GVKHRSSGRDRERASLPLIRSRRAANR--HPHFPQYNYQVQVAENQPPGTPV-----ITMSAQDP 691

  Fly  7273 QTTESTR------DVPTTRPFE-----SSTPRPVTLEI------------------AVPPVTSET 7308
            .|.|:.|      .:..::..|     |.|....|:||                  ..|.:::  
 Frog   692 DTGEAGRLRYTMDALMNSKSLELFSIDSVTGLISTIEILDRESMDLHYFRVSAIDHGTPRLSA-- 754

  Fly  7309 TTNVAIGSTGGQVTEQTTSSP----SEVRTTIR--VEES--TLPSRSTDRTTPSES--------- 7356
            ||.|||     .|:::...||    ||.|.:||  |||.  .|..|:||..:.:.:         
 Frog   755 TTMVAI-----TVSDRNDHSPLFEQSEYRESIRENVEEGYPILQLRATDMDSQANANIKYRFVNE 814

  Fly  7357 PETPTTLPSD-----FTTRPHSDQTTESTRDVPTTRPFEASTPSPASLETTVPSVTLETTTSVPM 7416
            ....:....|     .||....|:.......:......:...|.|.|....|....|:...:||.
 Frog   815 QAAHSVFEIDARSGLITTSGQVDREKREKYSLIVEASDQGKDPGPRSSTVKVDITILDENDNVPQ 879

  Fly  7417 GSTGGQVTGQTTAPPSEVRTTIRVEESTLPSRSTDRTPPSESPETPTTLPSDFTTRPHSDQTTES 7481
            .              ||.|..::|.|.........|.       |.|.:..|.....|.:..:.:
 Frog   880 F--------------SEKRYIVQVREDIKTHTEIVRV-------TATDIDKDSNALVHYNIISGN 923

  Fly  7482 SR----------DVPTTQPFESSTPRPVTLEIAV-----PPVTSETTT----------------- 7514
            ||          :|....|.:..|.|..||.:..     ||:::.|.|                 
 Frog   924 SRGQFSIDSVTGEVQIVTPLDFETEREYTLRVRAQDAGRPPLSNNTGTISIQVVDVNDHAPIFVS 988

  Fly  7515 ---------NVPIGST-----------------GGQVTGQTTATPSEVRTTIG------------ 7541
                     |.|:|.:                 ..::||....:|..:.:..|            
 Frog   989 TPFQVSVLENAPLGHSIIHIQAIDADYGENSRVEYKLTGMKPESPFVINSATGWITVSGPLDREM 1053

  Fly  7542 VEESTLPSRSTDRTTPSESPETPTTLPSDFTTRPHSDQTTESTRDVPTTRPFEASTPSPASLETT 7606
            ||:......:.|...||.|.....|:    |....:|...|.|:     |.:.......|::.|:
 Frog  1054 VEQYVFGVEARDHGNPSLSASAGVTI----TIMDVNDNRPEFTQ-----REYFIRLNEDATVGTS 1109

  Fly  7607 VPSVT-LETTTNVPIGSTGGQVTGQTTATPSEVRTTIGVEESTLPSRSTDRTTPSESPETPTTLP 7670
            |.||| ::...|..|..   |:||..|.....:.|..|....||                  :||
 Frog  1110 VLSVTAIDRDVNSAITY---QITGGNTRNRYAISTQGGSGLITL------------------SLP 1153

  Fly  7671 SDF-TTRPHSDQTTESTR--------DVPTTRPFEASTPRPVTLETAVPSVTSETTTNVPIGSTV 7726
            .|: ..|.:....|.|.|        .:..|   :|:|.|||......|...:|   :.||||||
 Frog  1154 LDYKQERRYVLTVTASDRILHDNCYVHINIT---DANTHRPVFQSAHYPVDINE---DRPIGSTV 1212

  Fly  7727 TSETTTNVPIGSTGGQVAGQTTAPPSEVRTTIRVEESTLPSRSADRTTPSESPETPTTLPSDFTT 7791
            ...:.::..:|              ...|.|..:|:: :|....|       |:|     ...|.
 Frog  1213 VIISASDEDVG--------------ENARITYSLEDN-IPQFRID-------PDT-----GAITL 1250

  Fly  7792 R---PHSEQTTESTRDVPTTRPFEASTPSPASLETT-VPSVTSETTTNVP-IGST--GGQLTEQS 7849
            |   .:.:|.|.      |..........|...:|| |..:.::...|.| ..:|  .|.::|.:
 Frog  1251 RAMLDYEDQVTY------TLAVIAKDNGIPQKSDTTYVEIMVNDVNDNAPQFANTQYHGIVSEDA 1309

  Fly  7850 TSSPSEVRTTIRVEESTLPSRSTDRTFPSESPEKPTTL-----PSDFTTRPHLEQTTESTRDV-- 7907
            ....|.|:.:           :|||...|....:.|..     ..|||    :|.|:...|.|  
 Frog  1310 PPFTSVVQIS-----------ATDRDSHSNGRVQYTFQNGDDGDGDFT----IEPTSGIIRTVRK 1359

  Fly  7908 ----------LTTRPFETSTP---SPVSLETTVPSVTSE------------TSTNVPIGSTGGQV 7947
                      ||....:...|   |||.::..|..|...            ...|..:||..|::
 Frog  1360 LDRESVPFYELTAYAVDRGMPPLRSPVRIQVAVQDVNDNAPVFPADEFEVYVKENSIVGSVVGKI 1424

  Fly  7948 TEQTTAP---PSVRTTETIVKSTHPAV--------------------SPDTTIPSEIPATRVPLE 7989
              :.|.|   |:.:....||:...|.:                    .|:..|  .:.||..||.
 Frog  1425 --KATDPDEGPNAQIMYQIVEGNIPEIFQMDFFSGELTALIDLDYEAKPEYVI--VVQATSAPLV 1485

  Fly  7990 S--TTRL-YTDQ-----------------------TIPPGSTDRTTSSERPDESTRL--TSEEST 8026
            |  |.|: ..||                       |.|.|...:..:.: ||.|.||  |.|...
 Frog  1486 SRATVRIKLIDQNDNSPVLKNFQILFNNYISNSSNTFPSGVIGKIPAYD-PDVSDRLLYTFERGN 1549

  Fly  8027 E--------------------TTRPVPT---VSPRDALETTVTS------LITETTKTTSGGTPR 8062
            |                    ..||:..   |:..|.:.:....      :|||...:.|     
 Frog  1550 ELSLLIVNHSSGELRLSRKLDNNRPLVASMLVTVTDGIHSVTAQCVLRVLIITEDMLSNS----- 1609

  Fly  8063 GQVTER-----TTKSVSELTTGRSSDVVTERTMPS------NISSTTTV---------------- 8100
              :|.|     ..:.:|.|.|.....|.|....|.      ||.:.|.|                
 Frog  1610 --ITVRLENMSQERFLSPLLTSFLEGVSTVLATPKEDIFIFNIQNDTDVAGSVLNVSFSALAPHG 1672

  Fly  8101 ----FNNSEPVSDNLPTTISITVTDSPTTVPVPTCKTDYDCLDEQTCIGGQCISPCEYFTNLCTV 8161
                |.:||.:.:.|... .:|:|.:.....:|        .|:..|:.    .|||.:....:|
 Frog  1673 DRSQFLSSEDLQEQLYMK-RMTLTSASMLEVLP--------FDDNVCLR----EPCENYMKCISV 1724

  Fly  8162 -----------QNLTICRTLNHTT--KCYCDTDDDVNRPDCSMKAEIGCASSDECPSQQACINAL 8213
                       ....:.|.::..|  :|.|...                .:.|.|..:   || |
 Frog  1725 LKFDSSAPFIASESILFRPIHPITGLRCRCPQG----------------FTGDYCEIE---IN-L 1769

  Fly  8214 CVDPCTFNNPCSRNEDCRVFNHQPLCSAEHGRTPGCEHCPPGANC--DPTTGACIKANVTITTIT 8276
            |     ::|||.....|        ...|.|.|..|.....|.||  |..:|.|:..      :.
 Frog  1770 C-----YSNPCQNGGVC--------ARREGGYTCMCRERFTGDNCEVDSGSGRCVPG------VC 1815

  Fly  8277 TKNSTSTKIPTKPRTTANPNTG---------VKTTPTTTRVTTRNTTTTTTTTTTSSTSTESSTI 8332
            ....|...:.....|...|:.|         .::.|..:.|..|........:.:.|.:|:....
 Frog  1816 RNGGTCVNLAEGGFTCQCPSGGFEKPFCELSTRSFPPKSFVMFRGLRQRFHMSLSLSFATKERNG 1880

  Fly  8333 TSATNQTSKNQKPDTESTTSHTDATR-RYRDGENNITDTPTPRPTI-----QTTTLR-----GEG 8386
            ....| ...|:|.|..:...:....: :|..||::...||.....:     .|..||     ..|
 Frog  1881 LLFYN-GRLNEKHDFIAVEINDGQVQLKYSTGESSTLVTPYVAGGVSDGRWHTVLLRYYNKPKTG 1944

  Fly  8387 VMGDSQRRSTTTPKMKTTRLDTSNEVPDTTSPWPIELPTTEGTTTEVYNTMFAPVVNTTDTS--L 8449
            .||.:|  ..:..|:....:|..:          |.:....|:....|:.....|.:::..|  |
 Frog  1945 SMGVAQ--GPSREKIAVLAVDDCD----------ISVALKFGSEIGNYSCAAEGVQSSSKKSLDL 1997

  Fly  8450 INPCTVDTNCAPNEHCKLGHCRKKEPPGSPKTPEPCQSNNDCIESEACYMGLCQD------PCEF 8508
            ..|..            ||        |.|..||    |......|  ::|..:|      ..:|
 Frog  1998 TGPLL------------LG--------GVPNLPE----NFPVAHRE--FIGCMRDLYVDNKKIDF 2036

  Fly  8509 AKICA---ATAKCTAKSHRPVCTCPQGHEGNPMVKCVTTQTSIECTDDSDCGVTEACINQLCQHP 8570
            |...|   .:|.|..|  ...|      :.||            |.:...|.||....|      
 Frog  2037 ASYIANNGTSAGCHGK--HTFC------DSNP------------CKNGGTCSVTWGSFN------ 2075

  Fly  8571 CDVHDPCATNAVCINSNHAADCSCADGFQG-------------NG------------------FV 8604
                                 |:|..||.|             ||                  |:
 Frog  2076 ---------------------CNCPLGFGGKDCRIALQYAYQFNGSSLLSWDFKNDVKISVPWFL 2119

  Fly  8605 GCQ---------PARSHVCQYNEDCPPTKLCDRLNRRCINPCQEDSCGENA-------------- 8646
            |..         ..::|..||.     |.||..::..........|...:|              
 Frog  2120 GLAFRTRRADGVLLQAHAGQYT-----TILCQLVSGLISFSVSRGSSRTSALLLDQMLVNDGKWH 2179

  Fly  8647 ----ECIPVNHGTECRCL------PGF----------LGNAYVQCLPSQGCRSDSECDSS-QACI 8690
                |...|..|.|.|.:      .||          |....|:.|...|.....|..:. :.||
 Frog  2180 DLQMELRDVRSGRETRYVISINLDYGFYQDTVTVGSELHGLRVKNLYIGGVSGPREVQNGFEGCI 2244

  Fly  8691 NGKCSSPCQCGAYALCDVVNHRGVCKCPPGYNGNPKVGCSPPQDPCDPNPCGLNALCELDNGNPI 8755
            .|     .:.|.       ...|:....|....|.|.||..| :.||.|||..|:.|..:..:..
 Frog  2245 QG-----VRLGE-------TPSGITLPKPSSALNVKPGCGVP-NMCDSNPCPGNSSCVNEWMSYS 2296

  Fly  8756 CYCPKGLTGNPFKNCIPEGDECTPNPCGPNSGCRRVGGNPV---CFCLPEYEGQPPSIPCE---- 8813
            |.|..|..|   :|||   |.|..|||.....||.....|:   |.|...:.|:    .||    
 Frog  2297 CVCHPGYYG---ENCI---DVCQLNPCENRGVCRHQPSAPMGYTCECSKNHIGR----YCEHRLD 2351

  Fly  8814 --LPSNPCDPSPCGPNTQCSVLSNGF--------SKCTCLPNYVESPNTIRGCVEPINPCDPNPC 8868
              .|......:.||| ..|.| :.||        .:|.| ..:...|.....|:    |||    
 Frog  2352 QQCPKGWWGNATCGP-CHCDV-NKGFDPDCNKTNGQCNC-KEFHYRPKGSETCL----PCD---- 2405

  Fly  8869 GTGAICDSSRHPVCYCPDNKIGNPFRLCDKPAVTIELCQPGPCGRNAECYVAGNREECYCRSGYV 8933
                         ||    .||:..|.||:        :.|               :||||.|.:
 Frog  2406 -------------CY----PIGSSSRACDQ--------ETG---------------QCYCRPGVI 2430

  Fly  8934 GDAYQGCREPSRTVCDPNPCGPNANCVVAGDGQTACVCPDGLSGD---PTSVIGCHGYECQVDAD 8995
            |.....|..|...|   :|.|    |.|..||     ||..|:..   |.:..|       :.|.
 Frog  2431 GRECNNCDSPFAQV---SPSG----CEVIYDG-----CPKTLTAGVWWPRTKFG-------LPAA 2476

  Fly  8996 CPNSKACMGYRCYDPCPGACGQGA---HC 9021
            .|..|..:|.|         |:||   ||
 Frog  2477 VPCPKGSLGLR---------GKGAAIRHC 2496

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dpyNP_001260032.1 EGF_3 137..166 CDD:289699
EGF_CA 212..247 CDD:238011
EGF_CA 255..>286 CDD:214542
EGF_CA 298..331 CDD:238011
EGF_CA 338..373 CDD:238011
EGF_CA 413..456 CDD:238011
EGF_CA 457..490 CDD:238011
EGF_CA 497..>529 CDD:214542
EGF_CA 580..>612 CDD:214542
EGF_3 676..702 CDD:289699
EGF_CA 1022..1056 CDD:214542
EGF_CA 2227..2260 CDD:238011
EGF_CA 2393..>2422 CDD:214542
DUF4758 4088..4282 CDD:292572
DUF4696 4127..4678 CDD:292395
DUF4758 4275..4448 CDD:292572
DUF4758 4377..4574 CDD:292572
DUF4758 4581..4754 CDD:292572
DUF4758 4683..4847 CDD:292572
DUF4758 4785..4964 CDD:292572
DUF4696 4841..5385 CDD:292395
DUF4758 4887..5098 CDD:292572
DUF4758 5193..5371 CDD:292572
DUF4758 5294..5487 CDD:292572
DUF4758 5445..5650 CDD:292572
DUF4758 5700..5877 CDD:292572
DUF4696 5756..6396 CDD:292395
DUF4758 5802..5979 CDD:292572
DUF4758 5964..6171 CDD:292572
DUF4758 6181..6360 CDD:292572
DUF4696 6339..6999 CDD:292395
DUF4758 6662..6839 CDD:292572
DUF4758 6764..6941 CDD:292572
DUF4758 6866..7045 CDD:292572
DUF4758 6968..7179 CDD:292572 21/95 (22%)
DUF4696 7024..7569 CDD:292395 115/611 (19%)
DUF4758 7172..7383 CDD:292572 54/270 (20%)
DUF4696 7330..7964 CDD:292395 152/773 (20%)
DUF4758 7400..7587 CDD:292572 44/256 (17%)
DUF4758 7538..7707 CDD:292572 42/190 (22%)
DUF4758 7798..7979 CDD:292572 45/239 (19%)
DUF4758 7946..8126 CDD:292572 54/290 (19%)
YppG 18767..>18832 CDD:290883
Med25_SD1 18795..18955 CDD:288132
MISS 19026..19258 CDD:292450
ZP 22576..22811 CDD:214579
Zona_pellucida <22714..22810 CDD:278526
celsr3XP_031757039.1 Cadherin_repeat 669..768 CDD:206637 20/110 (18%)
Cadherin_repeat 776..876 CDD:206637 20/99 (20%)
Cadherin_repeat 885..982 CDD:206637 19/103 (18%)
Cadherin_repeat 990..1087 CDD:206637 15/100 (15%)
Cadherin_repeat 1095..1189 CDD:206637 25/117 (21%)
Cadherin_repeat 1197..1292 CDD:206637 25/130 (19%)
Cadherin_repeat 1300..1398 CDD:206637 24/112 (21%)
Cadherin_repeat 1406..1500 CDD:206637 21/97 (22%)
Cadherin_repeat 1520..1601 CDD:206637 15/81 (19%)
EGF_CA 1767..1802 CDD:238011 14/48 (29%)
EGF_CA 1812..1844 CDD:238011 4/37 (11%)
LamG 1847..2030 CDD:238058 40/221 (18%)
EGF_CA 2056..2087 CDD:238011 13/75 (17%)
Laminin_G_2 2123..2252 CDD:396680 24/145 (17%)
EGF_CA 2277..2309 CDD:238011 12/34 (35%)
EGF_CA 2309..2347 CDD:238011 12/44 (27%)
EGF_Lam 2404..2449 CDD:214543 21/95 (22%)
HormR 2453..2519 CDD:214468 17/65 (26%)
GAIN 2536..2777 CDD:406802
GPS 2805..2854 CDD:413374
7tmB2_CELSR3 2865..3118 CDD:320659
TM helix 1 2868..2892 CDD:320659
TM helix 2 2901..2922 CDD:320659
TM helix 3 2932..2954 CDD:320659
TM helix 4 2973..2989 CDD:320659
TM helix 5 3008..3031 CDD:320659
TM helix 6 3054..3076 CDD:320659
TM helix 7 3080..3105 CDD:320659
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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