DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpy and nedd9

DIOPT Version :9

Sequence 1:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster
Sequence 2:	XP_002932712.1	Gene:	nedd9 / 100487989	XenbaseID:	XB-GENE-490926	Length:	782	Species:	Xenopus tropicalis

Alignment Length:	444	Identity:	88/444 - (19%)
Similarity:	132/444 - (29%)	Gaps:	165/444 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly  5954 QTTAPPSEVRTTIG-VEESTLPSRSTDRTSPSESPETPTTLPSDFITRPHSEQTTESTRDVPTTR 6017
            |..||.:.::..|| |.||.....:.....|.      ..||......|.:.. .:|...||
Frog    52 QGIAPGNRLKLLIGPVSESYKHENTKQEAHPQ------NFLPQQIYQVPQASY-QDSVYQVP--- 106

  Fly  6018 PFEASTPSPASLKTTVPSVTSEATTNVPIGSTGQRIGTTPSESPETPTTLPSDFTTRP------- 6075
                    |:....||..|:...|                ||..:..|.||....:.|
Frog   107 --------PSQHNPTVYKVSRGYT----------------SEDKKPMTALPESMDSSPGNKVKCQ 147

  Fly  6076 ------HSEKTTE----STRDVPTTRPFETSTPSPASLETTVPSVTLETTTNVPIGSTGGQVTEQ 6130
                  :|...|.    |..|:|.|||                    :...:||..:.|...
Frog   148 PRMTQGYSHDCTSRWQTSVYDIPPTRP--------------------QGVYDVPATAKGSMY--- 189

  Fly  6131 TTSSPSEVRTTIRVEESTLPSRSADRTTPSESPETPTLPSDFTTRPHSEQTTESTRDVPTTRPFE 6195
             :|||::.:....|..    |::...|.||.:.:....||.      |::|.|.|.||
Frog   190 -SSSPTKDQGIYDVPS----SQAVYNTLPSNNGKMYDFPSS------SKKTVEPTYDV------- 236

  Fly  6196 ASTPSPASLETTVPSVTSETTTNVPIGSTGGQVTGQTTAPPSEVRTTIGVEESTLPSRSTDRTSP 6260
                                                  .|||.  ||...|:|.       :.|.
Frog   237 --------------------------------------LPPSS--TTFSQEKSR-------KVSM 254

  Fly  6261 SESPETPTTLPSDFITRPHSEQTTESTRDVPTTRPFEAST------------PSPASLKTTVPSV 6313
            ..||....|..|.....|.|:||...|.|....|..::..            |..||.::.|...
Frog   255 VVSPPLEATRKSSVYDFPRSQQTQPQTDDYDFPRGIQSENFVSDGQDGVYDFPPQASERSKVVQD 319

  Fly  6314 TSEATTNVPIGSTGGQVTEQTTSSPSEVRTTIRVEESTLPSRSTDRTTPSESPE 6367
            .::....:...|||...:..:|||.:.       :||::.|      :||:.|:
Frog   320 VTDGVNRLSFSSTGSTRSNMSTSSTTS-------KESSVTS------SPSQDPK 360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpy	NP_001260032.1	EGF_3	137..166	CDD:289699
		EGF_CA	212..247	CDD:238011
		EGF_CA	255..>286	CDD:214542
		EGF_CA	298..331	CDD:238011
		EGF_CA	338..373	CDD:238011
		EGF_CA	413..456	CDD:238011
		EGF_CA	457..490	CDD:238011
		EGF_CA	497..>529	CDD:214542
		EGF_CA	580..>612	CDD:214542
		EGF_3	676..702	CDD:289699
		EGF_CA	1022..1056	CDD:214542
		EGF_CA	2227..2260	CDD:238011
		EGF_CA	2393..>2422	CDD:214542
		DUF4758	4088..4282	CDD:292572
		DUF4696	4127..4678	CDD:292395
		DUF4758	4275..4448	CDD:292572
		DUF4758	4377..4574	CDD:292572
		DUF4758	4581..4754	CDD:292572
		DUF4758	4683..4847	CDD:292572
		DUF4758	4785..4964	CDD:292572
		DUF4696	4841..5385	CDD:292395
		DUF4758	4887..5098	CDD:292572
		DUF4758	5193..5371	CDD:292572
		DUF4758	5294..5487	CDD:292572
		DUF4758	5445..5650	CDD:292572
		DUF4758	5700..5877	CDD:292572
		DUF4696	5756..6396	CDD:292395	88/444 (20%)
		DUF4758	5802..5979	CDD:292572	8/25 (32%)
		DUF4758	5964..6171	CDD:292572	43/224 (19%)
		DUF4758	6181..6360	CDD:292572	37/190 (19%)
		DUF4696	6339..6999	CDD:292395	6/29 (21%)
		DUF4758	6662..6839	CDD:292572
		DUF4758	6764..6941	CDD:292572
		DUF4758	6866..7045	CDD:292572
		DUF4758	6968..7179	CDD:292572
		DUF4696	7024..7569	CDD:292395
		DUF4758	7172..7383	CDD:292572
		DUF4696	7330..7964	CDD:292395
		DUF4758	7400..7587	CDD:292572
		DUF4758	7538..7707	CDD:292572
		DUF4758	7798..7979	CDD:292572
		DUF4758	7946..8126	CDD:292572
		YppG	18767..>18832	CDD:290883
		Med25_SD1	18795..18955	CDD:288132
		MISS	19026..19258	CDD:292450
		ZP	22576..22811	CDD:214579
		Zona_pellucida	<22714..22810	CDD:278526
nedd9	XP_002932712.1	SH3_NEDD9	7..63	CDD:212935	3/10 (30%)
		Serine_rich_NEDD9	360..521	CDD:211404	0/1 (0%)
		DUF3513	576..776	CDD:371854
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910