DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment dpy and crb2

DIOPT Version :9

Sequence 1:NP_001260032.1 Gene:dpy / 318824 FlyBaseID:FBgn0053196 Length:22949 Species:Drosophila melanogaster
Sequence 2:XP_002937280.2 Gene:crb2 / 100487355 XenbaseID:XB-GENE-989701 Length:1456 Species:Xenopus tropicalis


Alignment Length:1659 Identity:359/1659 - (21%)
Similarity:499/1659 - (30%) Gaps:660/1659 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly    91 LKCTNDCDKDGTKCTHGACLNG----VCHCNDGYGGCNCVDKDENECKQRPCDVFAHCTNTLGSF 151
            |.|||:|.::.....:..|..|    :|.|..||||.:| :.:.:.|.|.||...|.|.....||
 Frog   101 LNCTNECQRNSCPFQNFQCTVGEDSFMCKCQSGYGGVDC-NFEVSPCFQNPCQNNATCLAEGDSF 164

  Fly   152 TCTCFPGYRGNGFHCE-DIDEC-QDPAIAARCVENAECCNLPAHFLCKCKDGYEGDGEVLC-TDV 213
            .|.|.||:.|.  .|| :::|| .:|     |...|.|.:....::|.|..|::|..   | .|:
 Frog   165 RCVCEPGFTGQ--ECEVNVNECASNP-----CQNEALCVDKVDRYMCFCVPGFQGHH---CEIDI 219

  Fly   214 DECRNPENCGPNALCTNTPGNYTCSCPDGYVGNNPYREGCQ-DVDEC-SYPNVCGPGAICTNLEG 276
            :||.: ..|..|..|.|....|.|:|.:||.|.|     |: ::||| |.|  |..||.|.:..|
 Frog   220 NECAS-RPCQNNGTCMNQLDQYECACANGYTGIN-----CEMEIDECQSVP--CQNGATCRDHIG 276

  Fly   277 SYRCDCPPGYDGDGRSESGCVDQDECARTPCGRNADCLNTDGSFRCLCPD-GYSGDPMNGCE-DV 339
            .:.||||.||||:....    |.|||...||.....|::....|||.|.: |:.|   ..|| ::
 Frog   277 YFTCDCPAGYDGEQCQH----DIDECQSQPCQNGGQCMDEINRFRCDCSNTGFVG---GRCEVEI 334

  Fly   340 DECATNNPCGLGAECVNLGGSFQCRCPSGFVLEHDPHADQLPQPLNTQQLGYGPGATDIAPYQRT 404
            .|| .:|||.....|:.....::|.|..|:                                   
 Frog   335 LEC-DSNPCQNNGTCMERVNGYECLCWKGY----------------------------------- 363

  Fly   405 SGAGLAC-LDIDEC-NQPDGVAKCGTNAKCINF-------------------PGSYRCLCPSGFQ 448
              :|:.| :|.:|| .:|     |.....|:..                   ...|.|.|..||.
 Frog   364 --SGIHCEIDDNECFEEP-----CVNGGLCLELSNQSYYGTEPEFNKFSYSQAAGYLCRCQQGFT 421

  Fly   449 GQGYLHCE-NINECQDNPCGENAICTDTVGSFVCTCKPDYTGDPFRGCVDIDECTALDKPCGQHA 512
            |.   :|. ||:||:..||.....|||.:..|:|.|...|||  |...::||||.  |.||...|
 Frog   422 GP---NCSVNIDECESWPCLNGGTCTDLINGFLCNCASGYTG--FDCSINIDECK--DSPCKNGA 479

  Fly   513 VCENTVPGYNCKCPQG------YDGKPDPKVACEQVDVNILCSSNFDCTNNAECIENQCFCLDGF 571
            .||:.|..|:|.||..      :.||        ...|.::......|.|.||||          
 Frog   480 SCEDGVADYSCICPPAAQDGTVWGGK--------NCSVMLIGCLEHSCQNAAECI---------- 526

  Fly   572 EPIGSSCVDIDECRTHAEVCGPHAQCLNTPGSYGCECEAGYVGSPPRMACKQPC--EDVRCGAHA 634
             |:.:.       ::|               ||.|:|:.|:||:    .|..|.  ..:..|...
 Frog   527 -PLYTG-------QSH---------------SYTCKCQPGFVGN----NCSTPTTFSFLSQGYLM 564

  Fly   635 YCKPDQNEAY------------------------------------------------CVCEDGW 651
            |..|..||:|                                                .|.:|  
 Frog   565 YDSPLSNESYQSNMSVRFRTTLPDMVLMYRGDEDSFLALEIYNGFLHMRLKGNGRLFPLVIDD-- 627

  Fly   652 TYNPSDVAAGCVDID-------ECDVMHGPF--GSCGQNATCTNSAGGFTCACPPGFSG------ 701
             |..:|.....|::|       :..:.|...  |.|.|..|.|.   ||....|..|..      
 Frog   628 -YKVNDGHWHNVEVDLLSNSFLKISLFHNDCRNGLCSQKQTPTE---GFDPYLPESFRSLYIGGL 688

  Fly   702 ------------------------D-----PHS-----------KCVDVDECRTGASKCGAGAEC 726
                                    |     ||:           .|...:.|.  .:.|..||.|
 Frog   689 IQESLIKNTLSQQNFTGCLEDLVVDLVTQLPHNVSSDRSFGMVLGCKKAEVCH--PNPCHNGANC 751

  Fly   727 VNVPGGGYTCRC----PGNTIADPDPSVRCVP--IVSCSANEDCPGNSICDATKRCLCPEPNIGN 785
            ::: ...:||.|    .|:|         |:.  |......|..|.:|..:..:       :.|.
 Frog   752 IDL-WSSFTCECIRPFKGST---------CMQEYIAGTFFREGIPSHSYFELNQ-------DFGT 799

  Fly   786 DCRHPCEALNCGAHAQCMLANG---QAQCLCAP---GYTGNSALAGGCNDIDECRANPCAEKAIC 844
                   :.|..|..:.:.:||   |......|   .|..||.:     .|:...|.|...|   
 Frog   800 -------SFNISAFIRTLKSNGLLLQISYGTTPYFRTYLNNSWI-----HIETLSAQPLVFK--- 849

  Fly   845 SNTAGG-----------------------YLCQCP------------GG-SSGDP------YREG 867
            .|.:.|                       ||...|            || ::.|.      |.:|
 Frog   850 KNVSDGMKHFISISVREGNVTVTDLQQEVYLGMLPPVIITKGDAVHVGGLATADSTIFWGGYFKG 914

  Fly   868 CITSKTVGCSD------------------ANPCATGETCVQDSYTGNSVCICRQGYERNSENGQC 914
            |:....:. :|                  .|.....|.|:.|.       :|.||..||..|   
 Frog   915 CVQDLRIN-NDHLEFFHPEHINVQETLYFGNNTNVTENCISDD-------VCHQGPCRNEGN--- 968

  Fly   915 QDVDECSVQRGKPACGLNALCKNLPGSYECRCPQGHNGNPFIMCEICNTPECQCQSPYKLVGNSC 979
                 |||..               ..:.|.||....|.             :|:.|.     .|
 Frog   969 -----CSVTW---------------NDFVCSCPANFTGK-------------RCEEPV-----WC 995

  Fly   980 VLSGCSSGQAC---PSGAEC--------------------------------------------- 996
            ..|.|..|..|   |.|..|                                             
 Frog   996 RRSPCLPGSTCVDVPKGFVCLANVSFQGHSSAVFTPIISEEHNLTSISLAFRTRDRDAVLLQSSK 1060

  Fly   997 ------ISIAGGVSYCACPKGYQTQPDG----SCVDVDECEERGAQLCAFGAQCVNKPGSY---- 1047
                  |.|.||..:.....|  ...||    ..:||.:.......:....|..||...::    
 Frog  1061 NVDSVLIEIQGGYLFVDLQSG--NNVDGVQLNGTIDVADAIWHRVVITMERATKVNSHWTFQLDD 1123

  Fly  1048 SCHCPEGYQGDAYNGL-----CALAQ--RKCAADRECAANEKCIQPGECVCPPPYFLD---PQDN 1102
            |......::||..|.:     ..||:  ..|..|         :..|....|   |.|   ||.:
 Frog  1124 SVQKKFQWEGDNLNFMRNNISIVLAEGYTGCLGD---------VSIGGIYLP---FTDHVLPQQD 1176

  Fly  1103 NKCKSPCERFPCGINAKCTPSDPPQCMCEAGFKGDPL-LGCTDEDECSHLPCAYGAYCVNKKGGY 1166
            ...:                            |.|.| |||...|.||..||.:|..|.:....:
 Frog  1177 QFIR----------------------------KSDALELGCRGADVCSESPCLHGGTCQDLFNSF 1213

  Fly  1167 QCVCPKDYTGDPYKSGCIFESGTPKSKCLSN-DDCASNLACLEGSCVSPCSSLLCGSNAYCETEQ 1230
            .|.|...:.|               .:|..| |||.|: .||.|.|:.            .|.:.
 Frog  1214 SCTCRIGWNG---------------HRCEINIDDCKSS-PCLHGFCID------------LEADY 1250

  Fly  1231 HAGWCRCRVGYVKNGDGDCVSQCQDVICGDGALCIPTSEGPTCKCPQGQLGN----PFPGGSCST 1291
            .   |.|..||........::.||...|.:|..|:......|||||....|.    |||      
 Frog  1251 Q---CSCEAGYTSRNCEININDCQHHQCLNGGTCVDGVNNYTCKCPANYAGTFCQWPFP------ 1306

  Fly  1292 DQCSAARPCGERQICINGRCKERCEGVVCGIGATCDRNNGKCICEPNFVGNPDLICMPPIEQAKC 1356
                 ...|.:...|.||   .||...:.|         ..|.|.|.|.|.              
 Frog  1307 -----PEQCNKNITCFNG---GRCNSGIWG---------ANCTCRPGFSGR-------------- 1340

  Fly  1357 SPGCGENAHCEYGLGQSRCACNPGTFGNPYEGCGAQSKNVCQPNSCGPNAECRAVGNHISCLCPQ 1421
                             ||..|               .|.|:.|.|.....|:...|...|:|..
 Frog  1341 -----------------RCEIN---------------VNDCESNPCLNGGTCQDSVNTFKCICNS 1373

  Fly  1422 GFSGNPYIGCQDVDECANKP-----------CGL 1444
            .|||   :.|:..|..:..|           ||:
 Frog  1374 SFSG---VRCEKSDAASMFPFPLVGVAVPVTCGV 1404

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dpyNP_001260032.1 EGF_3 137..166 CDD:289699 11/28 (39%)
EGF_CA 212..247 CDD:238011 13/34 (38%)
EGF_CA 255..>286 CDD:214542 14/31 (45%)
EGF_CA 298..331 CDD:238011 12/33 (36%)
EGF_CA 338..373 CDD:238011 9/34 (26%)
EGF_CA 413..456 CDD:238011 12/62 (19%)
EGF_CA 457..490 CDD:238011 14/32 (44%)
EGF_CA 497..>529 CDD:214542 15/37 (41%)
EGF_CA 580..>612 CDD:214542 5/31 (16%)
EGF_3 676..702 CDD:289699 9/55 (16%)
EGF_CA 1022..1056 CDD:214542 6/37 (16%)
EGF_CA 2227..2260 CDD:238011
EGF_CA 2393..>2422 CDD:214542
DUF4758 4088..4282 CDD:292572
DUF4696 4127..4678 CDD:292395
DUF4758 4275..4448 CDD:292572
DUF4758 4377..4574 CDD:292572
DUF4758 4581..4754 CDD:292572
DUF4758 4683..4847 CDD:292572
DUF4758 4785..4964 CDD:292572
DUF4696 4841..5385 CDD:292395
DUF4758 4887..5098 CDD:292572
DUF4758 5193..5371 CDD:292572
DUF4758 5294..5487 CDD:292572
DUF4758 5445..5650 CDD:292572
DUF4758 5700..5877 CDD:292572
DUF4696 5756..6396 CDD:292395
DUF4758 5802..5979 CDD:292572
DUF4758 5964..6171 CDD:292572
DUF4758 6181..6360 CDD:292572
DUF4696 6339..6999 CDD:292395
DUF4758 6662..6839 CDD:292572
DUF4758 6764..6941 CDD:292572
DUF4758 6866..7045 CDD:292572
DUF4758 6968..7179 CDD:292572
DUF4696 7024..7569 CDD:292395
DUF4758 7172..7383 CDD:292572
DUF4696 7330..7964 CDD:292395
DUF4758 7400..7587 CDD:292572
DUF4758 7538..7707 CDD:292572
DUF4758 7798..7979 CDD:292572
DUF4758 7946..8126 CDD:292572
YppG 18767..>18832 CDD:290883
Med25_SD1 18795..18955 CDD:288132
MISS 19026..19258 CDD:292450
ZP 22576..22811 CDD:214579
Zona_pellucida <22714..22810 CDD:278526
crb2XP_002937280.2 EGF_CA <149..178 CDD:238011 11/30 (37%)
EGF_CA 180..216 CDD:238011 10/43 (23%)
EGF_CA 218..254 CDD:238011 14/41 (34%)
EGF_CA 257..292 CDD:238011 18/36 (50%)
EGF_CA 294..331 CDD:238011 13/39 (33%)
EGF_CA 336..369 CDD:238011 10/70 (14%)
EGF_CA 428..463 CDD:238011 16/36 (44%)
EGF_CA 466..>494 CDD:214542 14/29 (48%)
Laminin_G_2 582..712 CDD:366983 16/135 (12%)
EGF_CA 742..771 CDD:238011 9/38 (24%)
Laminin_G_2 807..921 CDD:366983 22/121 (18%)
EGF_CA <961..990 CDD:238011 11/64 (17%)
Laminin_G_2 1046..1160 CDD:366983 20/124 (16%)
EGF_CA 1196..1227 CDD:238011 8/45 (18%)
EGF_CA 1229..1264 CDD:238011 14/50 (28%)
EGF_CA 1266..1302 CDD:238011 11/35 (31%)
EGF_CA 1345..1381 CDD:238011 12/53 (23%)
Insulin_TMD <1396..1427 CDD:375394 2/9 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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