DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment dpy and notch2

DIOPT Version :9

Sequence 1:NP_001260032.1 Gene:dpy / 318824 FlyBaseID:FBgn0053196 Length:22949 Species:Drosophila melanogaster
Sequence 2:XP_002939126.3 Gene:notch2 / 100486344 XenbaseID:XB-GENE-6046917 Length:2455 Species:Xenopus tropicalis


Alignment Length:2121 Identity:556/2121 - (26%)
Similarity:755/2121 - (35%) Gaps:727/2121 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    74 CDGTQDCFLGADELSKELKC-TNDCDKDGTKCTHGACLNGVCHCNDGYGGCNCVDKDENECKQRP 137
            |||.| |...::....|.|| |||   ||         :..|.|.|.:.|..|  :.:|.|::..
 Frog    19 CDGLQ-CRGASEPCLNEGKCITND---DG---------SAYCKCTDAFVGKYC--QLQNPCQETI 68

  Fly   138 CDVFAHC--TNTLGSFTCTCFPGYRGNGFHCEDIDECQDP-----AIAARCVENAECCNLPAHFL 195
            |.....|  ::.|....|||.||:.|        :.|:.|     ::...|:....|     |.|
 Frog    69 CLNGGTCKVSSDLSKGVCTCAPGFGG--------ENCKQPVANVCSLTQPCMNGGTC-----HLL 120

  Fly   196 ------CKCKDGYEGDGEVLCTDVDECRNPENCGPNALCTNTPGNYTCSCPDGYVGNNPYREGCQ 254
                  |.|..|:.|:.   |..:|.|.: :.|...:.|......|||||..||.|..     |:
 Frog   121 TLELYDCICPFGWRGND---CKFIDACAS-QPCANGSTCIPNENQYTCSCQAGYTGLK-----CE 176

  Fly   255 -DVDECSYPNVCGPGAICTNLEGSYRCDCPPGYDGDGRSESGCVDQDECARTPCGRNADCLNT-D 317
             ||:||..|.:|..|..|.|..|||||.|.|||.|. |.||..:   .|:.:||.....|..| :
 Frog   177 VDVNECGPPGMCKNGGTCENFPGSYRCQCHPGYTGQ-RCESPFI---PCSPSPCMNGGTCRQTSE 237

  Fly   318 GSFRCLCPDGYSGDPMNGCE-DVDECATNNPCGLGAECVNLGGSFQCRCPSGFVLEHDPHADQLP 381
            .::.|.|..|:.|   ..|| ::|:|.::. |..|..||:...::.||||              |
 Frog   238 FAYECNCLPGFDG---KNCETNIDDCPSHK-CQNGGTCVDGVNTYNCRCP--------------P 284

  Fly   382 QPLNTQQLGYGPGATDIAPYQRTSGAGLACL-DIDECN-QPDGVAKCGTNAKCINFPGSYRCLCP 444
            |                       ..|..|. |:|||. ||:.   |.....|.|..|.|.|:|.
 Frog   285 Q-----------------------WTGQFCTEDVDECQLQPNA---CQNGGTCTNSNGGYNCVCV 323

  Fly   445 SGFQGQGYLHC-ENINECQDNPCGENAICTDTVGSFVCTCKPDYTGDPFRGCVDIDECTALDKPC 508
            :|:.|.   .| :||::|....|...:.|.|.|.||:|.|.....|   ..|...|.|  ...||
 Frog   324 NGWSGD---DCSQNIDDCATAACANGSTCIDRVASFICVCPEGKIG---LLCHKNDAC--FSNPC 380

  Fly   509 GQHAVCE-NTVPGYN-CKCPQGYDGKPDPKVAC-EQVDVNILCSSNFDCTNNAECIENQ----CF 566
            ...::|: |.:.|.. |.||.||.|     .|| |.:|...|.:|| .|.:..:|:..:    |.
 Frog   381 HMGSLCDTNPLTGQAICTCPSGYKG-----TACTEDIDECSLVNSN-PCEHAGKCVNTEGSFYCE 439

  Fly   567 CLDGFEPIGSSC-VDIDECRTHAEVCGPHAQCLNTPGSYGCECEAGYVGSPPRMACKQPCEDVRC 630
            |..||  .|..| :||:||.  :|.|...|.||:..|.:.|.|..||.                 
 Frog   440 CSKGF--TGPRCEMDINECL--SEPCQNDATCLDKIGGFTCLCMPGYK----------------- 483

  Fly   631 GAHAYCKPDQNEAYCVCEDGWTYNPSDVAAGCVDIDECDVMHGPFGSCGQNATCTNSAGGFTCAC 695
            |.|             ||              ::|:||  :..|   |..|..|.:....|.|.|
 Frog   484 GIH-------------CE--------------IEINEC--LSNP---CVNNGECVDKVNRFVCIC 516

  Fly   696 PPGFSGDPHSKC-VDVDECRTGASKCGAGAECVNVPGGGYTCRCPGNTIADPDPSVRCVPIVSCS 759
            ||||:|   |.| :|:|:|  .::.|..||:||:.| .||.|.|     |.....|.|       
 Frog   517 PPGFTG---SVCQIDIDDC--SSTPCQNGAKCVDHP-SGYDCIC-----ATGFTGVLC------- 563

  Fly   760 ANEDCPGNSICDATKRCLCPEPNIGNDCRHPCEALNCGAHAQCMLANGQAQCLCAPGYTGNSALA 824
                                |.||.|     ||...| .:..|........|:|.|||.|  |: 
 Frog   564 --------------------EENINN-----CEPPPC-HYGTCQDGIDSYTCICEPGYMG--AI- 599

  Fly   825 GGCND-IDECRANPCAEKAICSNTAGGYLCQCPGGSSGDPYREGCITSKTVGCSDANPCATGETC 888
              |:| ||||.:|||..:..|.:...||.|.|..|:|| |..|     |.|....:|||..| .|
 Frog   600 --CSDQIDECLSNPCLNEGRCVDLVNGYQCNCLPGTSG-PRCE-----KNVDDCASNPCTYG-NC 655

  Fly   889 VQ--DSYTGNSVCICRQGYERNSENGQCQ-DVDECSVQRGKPACGLNALCKNLPGSYECRCPQGH 950
            |.  :.|.    |:|..|:    ...||: |:|||:   ..| |.....|.|....:.|.||:|.
 Frog   656 VDGINRYD----CVCSPGF----TGPQCKDDIDECA---SNP-CHNGGTCVNEQNRFRCICPEGF 708

  Fly   951 NGNPFIMCEICNTPECQCQSPYKLVGNSCVLSGCSSGQACPSGAECISIAGGVSYCACPKGYQTQ 1015
                       ..|.|..|.. :.|.|.|:...|:..   .:|.:|:          |..|:..:
 Frog   709 -----------RQPSCFSQVD-ECVNNPCIHGNCTDD---VNGYKCL----------CQPGWTGK 748

  Fly  1016 PDGSC-VDVDECEERGAQLCAFGAQCVNKPGSYSCHCPEGYQGDAYNGLCALAQRKCAAD-RECA 1078
               .| ||.:||.   :..|..|..|.|....|.|.|.:|::|  ||         |..| .|||
 Frog   749 ---KCEVDKNECL---SNPCQNGGTCDNLVNGYRCSCKKGFKG--YN---------CQIDIDECA 796

  Fly  1079 ANEKCIQPG---------ECVCPPPYFLDPQDNNKCK---SPCERFPCGINAKCTPSDPPQ---C 1128
            :| .|:..|         .|.|..||     ....|:   :||...||.....|..|:..:   |
 Frog   797 SN-PCLNHGTCRDGINGYTCHCGLPY-----TGTNCQNILTPCSPEPCHNGGICQESEDFKSFSC 855

  Fly  1129 MCEAGFKGDPLLGCT-DEDECSHLPCAYGAYCVNKKGGYQCVCPKDYTGDPYKSGCIFESGTPKS 1192
            :|..|:.|.   .|| |.|||...||.....|.|.||||.|.|.:.:.|               .
 Frog   856 LCATGWHGQ---RCTIDIDECITNPCKNYGRCQNTKGGYICHCFEGFNG---------------V 902

  Fly  1193 KCLSN-DDCASNLACLEG-SCVSPCSSLLCGSNAYCETEQHAGWCRCRVGYVKNGDGDCVSQCQ- 1254
            .|.:| |||.|| .|..| |||.       |.|.:.        |.|..|:  :||     :|| 
 Frog   903 NCENNIDDCLSN-PCQNGASCVD-------GINTFS--------CNCLAGF--HGD-----KCQK 944

  Fly  1255 DVICGDGALCIPTSEGPTCKCPQGQLGNPFPGGSCSTDQCSAARPCGERQICINGRCKERCEGVV 1319
            ||                                   |:| |:.||                   
 Frog   945 DV-----------------------------------DEC-ASNPC------------------- 954

  Fly  1320 CGIGATCDRNNGKCICEPNFVGNPDLICMPPIEQAKCSPGCGENAHCEYGLGQSRCACNPGTFGN 1384
                    :|.|.|   .::|.:  ..|       ||.||. :..||:..:.:            
 Frog   955 --------KNGGSC---TDYVNS--YTC-------KCQPGF-DGIHCDNNIDE------------ 986

  Fly  1385 PYEGCGAQSKNVCQPNSCGPNAECRAVGNHISCLCPQGFSGNPYIGCQ-DVDECANKPCGLNAAC 1448
                        |...||...|.|....|..:|.|||||:|.   .|. :::||.:.||.....|
 Frog   987 ------------CTDTSCFNGATCVDGINSFTCQCPQGFTGQ---FCLFEINECGSHPCINGGTC 1036

  Fly  1449 LNRAGGFECLCLSGHAGNPYSSCQPIESKFCQDANKCQCNERVECPEGYSCQKGQCKNLCSQASC 1513
            ::..|.:.|.|..|:.|.                   .|.|.|:...|:.|:.   :.:|.|...
 Frog  1037 VDGMGTYHCTCPVGYRGK-------------------NCEELVDLCSGFPCKN---RGICKQVKT 1079

  Fly  1514 GPRAICDAGNCICPMGYIG------DPHDQVHGCSIRGQCGNDADCLHSEICFQLGKGLR-KC-- 1569
            .|:       ||||.|:.|      |...:| ..|.||....|. |.|:.||...|...| :|  
 Frog  1080 EPK-------CICPTGWTGIYCDIPDVSCEV-AASQRGVAVQDL-CQHAGICINTGFSHRCQCRQ 1135

  Fly  1570 ----------VDACSKIQCGPNALCVSEDHRSSCICSDGFFGNPSNLQVGCQPERTVPEEEDKCK 1624
                      :|.|:...|..:|.||.......|.|..|:.|      |.|:      .|.|:|:
 Frog  1136 GYIGSYCEGELDECASNPCQNSATCVDRHGGYECKCLPGYQG------VNCE------YEIDECQ 1188

  Fly  1625 SDQDCSRGYGCQASVNGIKECINLCSNVVCGP---NELCKINPAGHAICNCAESYVWNPVVSSCE 1686
            . |.|..|..|...||..:     ||   |.|   ..||:.|     |.:||.|           
 Frog  1189 I-QPCHNGGTCVDLVNQFR-----CS---CPPGTRGPLCEEN-----IDDCAPS----------- 1228

  Fly  1687 KPSLPDCTSDANCPD-----ASACRPDVLGVLKC---VAICDAFTCPANSV--CVARQHQGRCDC 1741
             ...|.|.:...|.|     :..|.|...|. :|   |..|.:..|.|...  |:...:...|.|
 Frog  1229 -SEGPHCFNGGRCLDKIGGYSCECLPGFAGE-RCEGDVNECLSNPCSAKGSLDCIQLDNNYLCKC 1291

  Fly  1742 LNGFVGNPNDRNGCQPAQKHHCRNHAECQESEACIKDESTQTLGCRPACDTVKC---GPRAVCVT 1803
            ..||.|             .||               |:.|.|     |.|..|   |..||.|.
 Frog  1292 KPGFTG-------------RHC---------------ETIQDL-----CPTRPCLNGGTCAVAVN 1323

  Fly  1804 NNHQAQCQCPPGPFAGDPYDPFNGCQSVPCVYNHDCPPSQMCNRMTHTCFDVCDEESC--GDNAI 1866
            ......||||||         |:|.:   |.|::                :.|....|  |:|  
 Frog  1324 MPEGFTCQCPPG---------FSGSK---CQYSN----------------NTCGHYKCKVGEN-- 1358

  Fly  1867 CLAEDHRAVCQCPPGFKGDPLPEVACTKQGGCAAGTCHPSAICEVTPEGPVCKCPPLFVGDAKSG 1931
            |:.......|.||.|..|:     ||..:.|||:..|..:.:|:...:.|...|           
 Frog  1359 CIKTPLGPRCYCPTGPAGN-----ACQSKLGCASQPCKNNGVCQRKDQPPYYTC----------- 1407

  Fly  1932 GCRPDGQCPNGDADCPANTICAGGVCQNPCDNACGSNAECKVINRKPVCSCPLRFQPISDTAKDG 1996
                  .||||                     ..|...|..:|:...:..||       |.|:||
 Frog  1408 ------NCPNG---------------------IVGLQCEILLIDGCHLHHCP-------DKARDG 1438

  Fly  1997 -CARTIS--KCLTD------------VDCGGAL-C---YNGQCRIACRNSQ------DCSDGESC 2036
             |.:..:  :||.|            .:|..:| |   :||||...|...:      :|.:.|| 
 Frog  1439 YCDQECNTHECLWDGGDCSLTMEDPWANCSSSLKCWEYFNGQCDELCNTPECLFDNFECQEKES- 1502

  Fly  2037 LKNVCVV--ACLDHSQCASGLACVEGHCTIGCRSNKECKQD 2075
               :|..  .|.||        ...|||...| :.|||..|
 Frog  1503 ---ICKYDKYCEDH--------YANGHCDKSC-NTKECGWD 1531

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dpyNP_001260032.1 EGF_3 137..166 CDD:289699 9/30 (30%)
EGF_CA 212..247 CDD:238011 12/34 (35%)
EGF_CA 255..>286 CDD:214542 16/30 (53%)
EGF_CA 298..331 CDD:238011 8/33 (24%)
EGF_CA 338..373 CDD:238011 10/34 (29%)
EGF_CA 413..456 CDD:238011 16/44 (36%)
EGF_CA 457..490 CDD:238011 11/32 (34%)
EGF_CA 497..>529 CDD:214542 10/33 (30%)
EGF_CA 580..>612 CDD:214542 12/31 (39%)
EGF_3 676..702 CDD:289699 10/25 (40%)
EGF_CA 1022..1056 CDD:214542 11/33 (33%)
EGF_CA 2227..2260 CDD:238011
EGF_CA 2393..>2422 CDD:214542
DUF4758 4088..4282 CDD:292572
DUF4696 4127..4678 CDD:292395
DUF4758 4275..4448 CDD:292572
DUF4758 4377..4574 CDD:292572
DUF4758 4581..4754 CDD:292572
DUF4758 4683..4847 CDD:292572
DUF4758 4785..4964 CDD:292572
DUF4696 4841..5385 CDD:292395
DUF4758 4887..5098 CDD:292572
DUF4758 5193..5371 CDD:292572
DUF4758 5294..5487 CDD:292572
DUF4758 5445..5650 CDD:292572
DUF4758 5700..5877 CDD:292572
DUF4696 5756..6396 CDD:292395
DUF4758 5802..5979 CDD:292572
DUF4758 5964..6171 CDD:292572
DUF4758 6181..6360 CDD:292572
DUF4696 6339..6999 CDD:292395
DUF4758 6662..6839 CDD:292572
DUF4758 6764..6941 CDD:292572
DUF4758 6866..7045 CDD:292572
DUF4758 6968..7179 CDD:292572
DUF4696 7024..7569 CDD:292395
DUF4758 7172..7383 CDD:292572
DUF4696 7330..7964 CDD:292395
DUF4758 7400..7587 CDD:292572
DUF4758 7538..7707 CDD:292572
DUF4758 7798..7979 CDD:292572
DUF4758 7946..8126 CDD:292572
YppG 18767..>18832 CDD:290883
Med25_SD1 18795..18955 CDD:288132
MISS 19026..19258 CDD:292450
ZP 22576..22811 CDD:214579
Zona_pellucida <22714..22810 CDD:278526
notch2XP_002939126.3 EGF_CA 141..176 CDD:238011 12/40 (30%)
EGF_CA 178..215 CDD:238011 20/37 (54%)
EGF_CA 256..292 CDD:238011 13/73 (18%)
EGF_CA 294..331 CDD:238011 15/42 (36%)
EGF_CA 334..369 CDD:238011 12/37 (32%)
EGF_CA 411..450 CDD:238011 11/41 (27%)
EGF_CA 452..488 CDD:238011 16/67 (24%)
EGF_CA 491..526 CDD:238011 16/42 (38%)
EGF_CA 528..564 CDD:238011 16/70 (23%)
EGF_CA 566..600 CDD:238011 14/44 (32%)
EGF_CA 604..639 CDD:238011 16/35 (46%)
EGF_CA 641..676 CDD:238011 12/43 (28%)
EGF_CA 678..713 CDD:238011 13/49 (27%)
EGF_CA 717..751 CDD:238011 8/50 (16%)
EGF_CA 753..789 CDD:238011 14/49 (29%)
EGF_CA 791..827 CDD:238011 11/41 (27%)
EGF_CA 869..905 CDD:238011 15/50 (30%)
EGF_CA 907..943 CDD:238011 18/58 (31%)
EGF_CA 945..980 CDD:238011 16/110 (15%)
EGF_CA 983..1018 CDD:238011 13/61 (21%)
EGF_CA 1022..1057 CDD:238011 10/53 (19%)
EGF_CA 1147..1181 CDD:238011 11/39 (28%)
EGF_CA 1184..1219 CDD:238011 13/43 (30%)
EGF_CA 1221..1261 CDD:238011 12/57 (21%)
EGF_CA 1263..1301 CDD:238011 12/65 (18%)
EGF_CA <1311..1342 CDD:238011 13/42 (31%)
Notch 1430..1456 CDD:395019 10/32 (31%)
Notch 1469..1497 CDD:395019 7/27 (26%)
Notch 1506..1535 CDD:395019 11/35 (31%)
NOD 1541..1595 CDD:399654
NODP 1621..1676 CDD:400155
JMTM_Notch_APP 1661..1742 CDD:425406
PHA03095 <1822..>2032 CDD:222980
ANK repeat 1829..1876 CDD:293786
ANK repeat 1879..1909 CDD:293786
ANK repeat 1911..1976 CDD:293786
ANK repeat 1978..2009 CDD:293786
PTZ00322 1984..>2086 CDD:140343
ANK repeat 2011..2042 CDD:293786
DUF3454 2371..2431 CDD:403221
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 45 1.000 Domainoid score I12014
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.910

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