DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpy and snap91

DIOPT Version :9

Sequence 1:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster
Sequence 2:	XP_012818222.1	Gene:	snap91 / 100170497	XenbaseID:	XB-GENE-1013213	Length:	916	Species:	Xenopus tropicalis

Alignment Length:	765	Identity:	160/765 - (20%)
Similarity:	256/765 - (33%)	Gaps:	212/765 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly  5436 IGSTGGQVTEQTTS------SPSEVRTTIRVEESTLPSRSADRTTPSESPETPTLPSDFTTRPHS 5494
            :|...|.:.:.|..      :||.:..|:....:||..:....:..|.||...:.|:...|.|::
Frog   257 VGIDKGDIPDLTQDGCIDEPAPSSLLETLEQHLNTLEGKKPGSSEGSGSPVGKSSPATTVTSPNA 321

  Fly  5495 EQTTESTRDVPTTRPFEASTPSSASLETTVP-------------SVTLETTTNVPIGST--GGQV 5544
                ..::.|.|:.|.:....:||:.....|             |.|..:.:.:|.|::  |..:
Frog   322 ----TPSKTVDTSPPIDLFATASAAAAICSPKLSNDLLDLQPDFSSTTVSASALPGGASAWGDLL 382

  Fly  5545 TEQTTSSPSEFRTTIRVEESTLPSRSADRTTPSESPETPTLPSDFTTRPHSEQTTESTRDVPTTR 5609
            .|.:.|:||         .||:.|            |.|.|...|:..|
Frog   383 GEDSLSAPS---------ASTVTS------------EAPQLSDPFSAEP---------------- 410

  Fly  5610 PFEASTPSPASLETTVPSVTSETTTNVPIGSTGGQVTGQT-TAPPSEVRTTIRVEESTLPSRSTD 5673
              .||..:|:  |||..|| |...||:|..|....:.|.. .|.|.|...|:  :.:..|
Frog   411 --SASIAAPS--ETTNSSV-SAAATNIPTSSAEVDLFGDAFAASPGEATATL--DGAAAP----- 463

  Fly  5674 RTTPSESPETPTI---------LPSDSTTRT------YSDQTTESTRDV--PTTRPFE---ASTP 5718
               |:.:|....:         .||:.:...      ::.:.||::..|  |||....   |:||
Frog   464 ---PTPAPVAAALDACSGHDPFAPSEGSAEAAPELDLFALKPTETSAPVVTPTTSAASTVLATTP 525

  Fly  5719 SP--------ASLETTVPSVTLETTTNVPIGSTGGQVTGQTTATPS-EVRTTIGVEESTLPSRST 5774
            ||        |:...|..:.|..||......:|....|..|||.|: ::...:....|..|:
Frog   526 SPPPPPAAVAAAAAATTTTTTTTTTATTTAATTSASTTTTTTAPPALDIFGDLFDSVSETPA--- 587

  Fly  5775 DRTSPSESPETPTTLPSDFTTRPHSDQTTES---TRDVPTTRPFEASTPSPASLETTVPSVTSET 5836
             .|.|..:|.........|::.||.......   |.|:.:...|.|...:||:    .|:.|..:
Frog   588 -ATKPDAAPSIDLFGTDAFSSPPHGASPVPEASLTGDLLSVDTFAAPAAAPAA----SPAKTESS 647

  Fly  5837 TTNVPIGSTGGQVTE------QTTSSPSEVRTTIGLEESTLPSRSTDRTSPSESPETPTTLPSDF 5895
            ......|...|.|.|      ..|||.:......|...|.:        :||.:|.||.   .:.
Frog   648 AVLDLFGDAFGGVAEPQPAAMAPTSSSASADLLAGFGGSFM--------APSPTPITPA---QNN 701

  Fly  5896 ITRPHSDQTTESTRDVPTTRPFEAS-----------TPSPASLETT--VPSVTSETTTNVPIGS- 5946
            :.:|..|....:::...:...|:||           |.:|||..::  .||..:.......:||
Frog   702 LIQPSFDAAFVTSQPAASASSFDASVFDGLGDLLIPTMTPASQPSSSLTPSAGNAGAAGKALGSD 766

  Fly  5947 --------TGGQVTGQTTAPPSEVRTTIGVEESTLPSRSTDRTSPSESPETPTTLPSDFITRPHS 6003
                    .|......||....:::...|.::.|    ......|..:|.|.:|
Frog   767 LDSSLASLVGNLGIAGTTVKKGDLQWNAGEKKLT----GGANWQPKVAPATWST----------- 816

  Fly  6004 EQTTESTRDVPTTRPFEASTPSPASLKTTVPSVTSEATTNVPIGSTGQRIGTTPSESPETPTTLP 6068
                    ..|::.|.:.||| |.|   .||...|.|.:..|:...|...||.....|:.|....
Frog   817 --------GGPSSSPMQGSTP-PVS---GVPPAASAAPSTQPVAGFGLPSGTGVPMMPQQPMMYG 869

  Fly  6069 SDFTTRPHSEKTTESTRDVPTTRPF----------ETSTPSPASLETTVP 6108
            .                  |..||.          .:.:|||||.....|
Frog   870 Q------------------PMIRPSFGGAAVPGAPLSPSPSPASQSPKKP 901

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpy	NP_001260032.1	EGF_3	137..166	CDD:289699
		EGF_CA	212..247	CDD:238011
		EGF_CA	255..>286	CDD:214542
		EGF_CA	298..331	CDD:238011
		EGF_CA	338..373	CDD:238011
		EGF_CA	413..456	CDD:238011
		EGF_CA	457..490	CDD:238011
		EGF_CA	497..>529	CDD:214542
		EGF_CA	580..>612	CDD:214542
		EGF_3	676..702	CDD:289699
		EGF_CA	1022..1056	CDD:214542
		EGF_CA	2227..2260	CDD:238011
		EGF_CA	2393..>2422	CDD:214542
		DUF4758	4088..4282	CDD:292572
		DUF4696	4127..4678	CDD:292395
		DUF4758	4275..4448	CDD:292572
		DUF4758	4377..4574	CDD:292572
		DUF4758	4581..4754	CDD:292572
		DUF4758	4683..4847	CDD:292572
		DUF4758	4785..4964	CDD:292572
		DUF4696	4841..5385	CDD:292395
		DUF4758	4887..5098	CDD:292572
		DUF4758	5193..5371	CDD:292572
		DUF4758	5294..5487	CDD:292572	12/56 (21%)
		DUF4758	5445..5650	CDD:292572	49/226 (22%)
		DUF4758	5700..5877	CDD:292572	47/199 (24%)
		DUF4696	5756..6396	CDD:292395	78/395 (20%)
		DUF4758	5802..5979	CDD:292572	40/207 (19%)
		DUF4758	5964..6171	CDD:292572	32/155 (21%)
		DUF4758	6181..6360	CDD:292572
		DUF4696	6339..6999	CDD:292395
		DUF4758	6662..6839	CDD:292572
		DUF4758	6764..6941	CDD:292572
		DUF4758	6866..7045	CDD:292572
		DUF4758	6968..7179	CDD:292572
		DUF4696	7024..7569	CDD:292395
		DUF4758	7172..7383	CDD:292572
		DUF4696	7330..7964	CDD:292395
		DUF4758	7400..7587	CDD:292572
		DUF4758	7538..7707	CDD:292572
		DUF4758	7798..7979	CDD:292572
		DUF4758	7946..8126	CDD:292572
		YppG	18767..>18832	CDD:290883
		Med25_SD1	18795..18955	CDD:288132
		MISS	19026..19258	CDD:292450
		ZP	22576..22811	CDD:214579
		Zona_pellucida	<22714..22810	CDD:278526
snap91	XP_012818222.1	ANTH	19..291	CDD:284961	6/33 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910