DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpy and filip1l

DIOPT Version :9

Sequence 1:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster
Sequence 2:	NP_001103956.1	Gene:	filip1l / 100004879	ZFINID:	ZDB-GENE-070410-7	Length:	1129	Species:	Danio rerio

Alignment Length:	632	Identity:	124/632 - (19%)
Similarity:	210/632 - (33%)	Gaps:	185/632 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly  6812 TEQTTSSPSEVRTTIGLEESTLPSRSTDRTS--PSESPETPTTLPSDFITRPHSDQTTESTRDVP 6874
            ||:..|  |::::.:.:.:..|.|..|....  .::|.|..|..|..:..:...::..:.|::|.
Zfish   565 TEEEKS--SDLQSKVSMMKKRLQSLETVERELLRNKSKEEHTKSPGPYRYQQEDNKVKDLTQEVE 627

  Fly  6875 TTR------------------PFEASTPSPASLETTVPSVTSETTTNVPIGSTGGQVTEQTTSSP 6921
            ..|                  .||:.....::.:....::..|..|:....|. .|:.|:..|:.
Zfish   628 RLRRKLKEMKVVEGDLLKTEDEFESLEKRYSNEQERAKALMEELETSRKELSK-YQLAEKEESNQ 691

  Fly  6922 SEVRTTIGLEESTLPSRSTDRTSPSESPETPTTLPSDFITRPHSDQTT-------------ESTR 6973
            .::......||....|..|......:..........:.|.|..:|.||             |..|
Zfish   692 EQILYKRLKEEEAKSSHLTREVEALKEKIHEYMGTEESICRLKTDHTTLQRKLTQQEVRNKELAR 756

  Fly  6974 DVPT-TRPFEASTPSSASLETTVPSVTLETTTNVPIGSTGGQVTEQTTSSPSEVRTTIRVEESTL 7037
            ::.| ||..|.....|.||.   |.:.....:::.: ||....|:.|.|.....:....:|.:.:
Zfish   757 EMETLTRELERYRRFSKSLR---PGMNGRRFSDLHV-STKEVQTDPTDSLSPNYKNLAPLERALV 817

  Fly  7038 PSRSTDRTTPSESPE---------TPTTLPS-------------DFTTRPHSDQTTESSR----- 7075
            ..:....:.|.:...         :|:.:.|             .|.....:.....:.|
Zfish   818 NGKLYVESDPEDEANYNEIHLTKCSPSLMNSVNNLNNNMRRVRGPFLKPRENHHAVNNKRQNGNH 882

  Fly  7076 ----DVPTTQPFEASTPRPVTLQ--------TAVLPVTSETTTNVPIGSTGGQVTEQTTSSPSEV 7128
                ||..|.    |..:||.::        ||.|.:||.|:.|.|  |........||.:|.:.
Zfish   883 VQQGDVVLTH----SPGQPVHIKVTPDHGHNTATLEITSPTSENAP--SYTSTAVIPTTGAPPKQ 941

  Fly  7129 RTTIRVEESTLPS-RSTDRTTPSESPETPTTLPSDFTTRPHSDQTTESSRDVPTTQPFESSTPRP 7192
            |.|| ::.|..|| :......|.|||.||....|..|...:|             |...|.:..|
Zfish   942 RITI-LQNSISPSGKPKGSPPPPESPCTPDRSLSPLTMTAYS-------------QTLTSESCGP 992

  Fly  7193 VTLETAVPPVTSETTTNVPIGSTGGQVTEQTTPSPSEVRTTIRIEESTFPSRSTDRTTPSE---- 7253
            :|.:.|:.|:               |:...||.||                   ||:.|:|
Zfish   993 LTPDRALSPI---------------QIVSVTTGSP-------------------DRSEPAELLGG 1023

  Fly  7254 ------SPE---------TPTTLPSDFTT----------RPHSDQTTESTRDVPTTRPFESSTPR 7293
                  |||         :.:|.|:..||          .|:....|.|.:.:   .|:.|..|.
Zfish  1024 QTVLRVSPERQNSWQIQRSNSTGPNVITTDDNKIHIHLGSPYIQAVTPSAKPI---GPYYSLGPE 1085

  Fly  7294 PVTLEIAVPPVTSET--------TTNVAIGSTGGQVTEQTTSSPSEV 7332
            |     .||.:.:.|        |:::.|..|.|.:     |.||::
Zfish  1086 P-----RVPVLNNGTPAKGNNKITSSIVIKPTSGPI-----SRPSQI 1122

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpy	NP_001260032.1	EGF_3	137..166	CDD:289699
		EGF_CA	212..247	CDD:238011
		EGF_CA	255..>286	CDD:214542
		EGF_CA	298..331	CDD:238011
		EGF_CA	338..373	CDD:238011
		EGF_CA	413..456	CDD:238011
		EGF_CA	457..490	CDD:238011
		EGF_CA	497..>529	CDD:214542
		EGF_CA	580..>612	CDD:214542
		EGF_3	676..702	CDD:289699
		EGF_CA	1022..1056	CDD:214542
		EGF_CA	2227..2260	CDD:238011
		EGF_CA	2393..>2422	CDD:214542
		DUF4758	4088..4282	CDD:292572
		DUF4696	4127..4678	CDD:292395
		DUF4758	4275..4448	CDD:292572
		DUF4758	4377..4574	CDD:292572
		DUF4758	4581..4754	CDD:292572
		DUF4758	4683..4847	CDD:292572
		DUF4758	4785..4964	CDD:292572
		DUF4696	4841..5385	CDD:292395
		DUF4758	4887..5098	CDD:292572
		DUF4758	5193..5371	CDD:292572
		DUF4758	5294..5487	CDD:292572
		DUF4758	5445..5650	CDD:292572
		DUF4758	5700..5877	CDD:292572
		DUF4696	5756..6396	CDD:292395
		DUF4758	5802..5979	CDD:292572
		DUF4758	5964..6171	CDD:292572
		DUF4758	6181..6360	CDD:292572
		DUF4696	6339..6999	CDD:292395	41/220 (19%)
		DUF4758	6662..6839	CDD:292572	6/26 (23%)
		DUF4758	6764..6941	CDD:292572	25/148 (17%)
		DUF4758	6866..7045	CDD:292572	36/210 (17%)
		DUF4758	6968..7179	CDD:292572	56/264 (21%)
		DUF4696	7024..7569	CDD:292395	78/386 (20%)
		DUF4758	7172..7383	CDD:292572	39/198 (20%)
		DUF4696	7330..7964	CDD:292395	1/3 (33%)
		DUF4758	7400..7587	CDD:292572
		DUF4758	7538..7707	CDD:292572
		DUF4758	7798..7979	CDD:292572
		DUF4758	7946..8126	CDD:292572
		YppG	18767..>18832	CDD:290883
		Med25_SD1	18795..18955	CDD:288132
		MISS	19026..19258	CDD:292450
		ZP	22576..22811	CDD:214579
		Zona_pellucida	<22714..22810	CDD:278526
filip1l	NP_001103956.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..59
		CortBP2	59..240	CDD:286770
		MIT_CorA-like	<227..>368	CDD:294313
		COG1340	319..648	CDD:224259	14/84 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	563..582		4/18 (22%)
		Ribosomal_S13	<615..>643	CDD:294236	3/27 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	894..975		26/83 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1110..1129		5/18 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910