DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Aladin and AT3G56900

DIOPT Version :9

Sequence 1:	NP_001285049.1	Gene:	Aladin / 31881	FlyBaseID:	FBgn0030122	Length:	466	Species:	Drosophila melanogaster
Sequence 2:	NP_191249.2	Gene:	AT3G56900 / 824857	AraportID:	AT3G56900	Length:	447	Species:	Arabidopsis thaliana

Alignment Length:	431	Identity:	114/431 - (26%)
Similarity:	181/431 - (41%)	Gaps:	80/431 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 FWKTLEEARSPETREQAPLIAQA------GDLIAQFLGLATGLRILPHTQQLSAERIAQFVETRD 134
            :.|.|....||.:.:..|...|.      ||..:   |.:.||  :...|...|:.:.|.::..|
plant    34 YGKVLGMVFSPVSFDSTPSSLQENEGQENGDKAS---GESKGL--VATLQMKVADSLKQILQPTD 93

  Fly   135 ---WLNSDVRYLAWNQHFFCLA-VAGVDDV-VRIYTKSSSATTATVLKSPSQTQITCMAWRPLCA 194
               ....|::.::|:|....:| ::|.:.| :|.| :........:|.|.||..:..:.|||...
plant    94 VTLLSEIDLQGVSWHQGKHIIAFISGANQVTIRDY-EDKDEKEPCILTSDSQRNVKALEWRPNGG 157

  Fly   195 SEIVIGCRQGLCFWEVD--STLHLGRTNAPS----------------EIFKYPNNLPITSMQWNK 241
            ..:.|.||.|:|.|...  ..:.|.|:...:                :..:..|:..|:::.|:.
plant   158 KSLSIACRGGICIWAASYPGNMALVRSGGSALRGSLSRGSGTRWILVDFLRCQNDEQISALSWSP 222

  Fly   242 DGTQLATASIGDRSIIIWQPDTGMMQPLKRLGPPG-SLLKWSPDNDWLFAATVDRVFRVWNCHQQ 305
            .|..||:||....|..||....|...|::| |..| |:|||||..|:.|||..|..|.:|..: .
plant   223 CGRYLASASYDSSSFTIWDVSQGAGTPIRR-GLGGISMLKWSPTGDYFFAARFDGTFCLWETN-T 285

  Fly   306 WTTERWVCGPG-GYVQTACWSPCGRFLLFVSSAEPILYRLQFVQQ--SLLSSSADEKEILP---- 363
            ||:|.|....| |.|..|.|.|.|||:|...|....|..:.|..:  ||      :..:||
plant   286 WTSEPWSLSSGSGSVTGAIWDPEGRFILISFSKSSTLGSVHFSSKPPSL------DAHLLPVELP 344

  Fly   364 -IADLNACSIDANRTLVGGPAQQLAWDPHGNYLVVTFKA-----TNCIAVF---RTFIQKFDLQI 419
             ||.|..|.          ..:::|||..|..|.|::|.     ...||::   ||.|    :..
plant   345 EIASLTGCE----------GIEKIAWDASGERLAVSYKGGDENYKGLIAIYDTRRTPI----VSA 395

  Fly   420 SAAYYLSGETAAEHPSFICFQPLYEDNDRS--VLTIAWSSG 458
            |...::.|  ..|:|..:.|.  :.|..:.  :|::.||:|
plant   396 SLVGFIRG--PGENPKALSFS--FHDKFKQGPLLSVCWSTG 432

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aladin	NP_001285049.1	WD40	<130..>420	CDD:225201	90/329 (27%)
		WD40 repeat	137..177	CDD:293791	8/41 (20%)
		WD40 repeat	184..227	CDD:293791	11/60 (18%)
		WD40 repeat	235..274	CDD:293791	12/38 (32%)
		WD40 repeat	276..312	CDD:293791	17/36 (47%)
		WD40 repeat	320..357	CDD:293791	12/38 (32%)
		WD40 repeat	364..400	CDD:293791	10/35 (29%)
		WD40 repeat	407..441	CDD:293791	8/36 (22%)
AT3G56900	NP_191249.2	WD40	83..>388	CDD:225201	88/323 (27%)
		WD40	<105..282	CDD:295369	50/178 (28%)
		WD40 repeat	105..141	CDD:293791	8/36 (22%)
		WD40 repeat	147..194	CDD:293791	11/46 (24%)
		WD40	215..419	CDD:295369	71/229 (31%)
		WD40 repeat	216..255	CDD:293791	13/39 (33%)
		WD40 repeat	257..283	CDD:293791	13/25 (52%)
		WD40 repeat	287..317	CDD:293791	13/29 (45%)
		WD40 repeat	322..372	CDD:293791	16/65 (25%)
		WD40 repeat	380..417	CDD:293791	10/44 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	45	1.000	Domainoid score	I4670
eggNOG	1	0.900	-	-		E1_KOG2139
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9232
Inparanoid	1	1.050	112	1.000	Inparanoid score	I2058
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D628517at2759
OrthoFinder	1	1.000	-	-		FOG0005612
OrthoInspector	1	1.000	-	-		oto3059
orthoMCL	1	0.900	-	-		OOG6_104613
Panther	1	1.100	-	-	LDO	PTHR14494
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5253
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.830