Protein Alignment Aladin and AAAS

DIOPT Version :9

• Sequence 1: NP_001285049.1
• Gene: Aladin / 31881
• FlyBaseID: FBgn0030122
• Length: 466
• Species: Drosophila melanogaster
• Sequence 2: XP_011537080.1
• Gene: AAAS / 8086
• HGNCID: 13666
• Length: 560
• Species: Homo sapiens
• Alignment Length: 498
• Identity: 149/498 - (29%)
• Similarity: 227/498 - (45%)
• Gaps: 78/498 - (15%)

  Fly     9 QCPPFSTLPDLALRHNHIPELERYPQINLNSELLANPAGQRYYGGQ-SFVSVNEGVLKRIARSFF 72
            :.||    ||...:..::|.|:      |..:.|..| |:..:|.: :|:...|.|.||....:.
Human    32 ESPP----PDFRGQWINLPVLQ------LTKDPLKTP-GRLDHGTRTAFIHHREQVWKRCINIWR 85

  Fly    73 NGGFWKTLEEARSPETREQAPLIAQAGDLIAQFLGLATGL-------------RILPHTQQLSAE 124
            :.|.:..|.|            ||.:.:.:.:::..|:|.             .:.||....|.:
Human    86 DVGLFGVLNE------------IANSEEEVFEWVKTASGWALALCRWASSLHGSLFPHLSLRSED 138

  Fly   125 RIAQFVETRDWLNSDVRYLAWNQHFFCLAVAGVDDVVRIYTKSSSATTATVLKSPSQTQITCMAW 189
            .||:|.:..:|.:..:|..||:.|....|||.:||.||:|  ::|:|....||...|..:..:||
Human   139 LIAEFAQVTNWSSCCLRVFAWHPHTNKFAVALLDDSVRVY--NASSTIVPSLKHRLQRNVASLAW 201

  Fly   190 RPLCASEIVIGCRQGLCFWEVDST-LHLGRTNAPSEIFKYPNNLPITSMQWNKDGTQLATASIGD 253
            :||.||.:.:.|:..:..|.:|.| |....::..:::..:|.:.|:||:.|...|.:|.:||..|
Human   202 KPLSASVLAVACQSCILIWTLDPTSLSTRPSSGCAQVLSHPGHTPVTSLAWAPSGGRLLSASPVD 266

  Fly   254 RSIIIWQPDTGMMQPLK--RLGPPGSLLKWSPDNDWLFAATVDRVFRVWNCHQQWTTERWVCGP- 315
            .:|.:|...|....||.  |.|...:|| ||||...:.|.|...|||||.. |.||.|||   |
Human   267 AAIRVWDVSTETCVPLPWFRGGGVTNLL-WSPDGSKILATTPSAVFRVWEA-QMWTCERW---PT 326

  Fly   316 -GGYVQTACWSPCGRFLLFVSSAEPILYRLQFVQQSLLSSS--ADEKEILPIADLNACSI---DA 374
             .|..||.||||.|..|||....||::|.|.|.::......  ...|....:|||:..:|   |.
Human   327 LSGRCQTGCWSPDGSRLLFTVLGEPLIYSLSFPERCGEGKGCVGGAKSATIVADLSETTIQTPDG 391

  Fly   375 NRTLVGGPAQQLAWDPHGNYLVVTFK-------ATNCIAVFRTFIQK-FD------------LQI 419
            ...| ||.|..:.|||.|..|.|..|       ....|.:|||.... |:            |..
Human   392 EERL-GGEAHSMVWDPSGERLAVLMKGKPRVQDGKPVILLFRTRNSPVFELLPCSLLASGCLLTF 455

  Fly   420 SAAYYLSGETAAEHPSFICFQPLYEDNDRSVLTIAWSSGRIQY 462
            |::..:.||..|: |..|.|.|.:  |..::|::.||:|||.:
Human   456 SSSGIIQGEPGAQ-PQLITFHPSF--NKGALLSVGWSTGRIAH 495

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Aladin	NP_001285049.1	WD40	<130..>420	CDD:225201	105/319 (33%)
		WD40 repeat	137..177	CDD:293791	14/39 (36%)
		WD40 repeat	184..227	CDD:293791	11/43 (26%)
		WD40 repeat	235..274	CDD:293791	14/40 (35%)
		WD40 repeat	276..312	CDD:293791	18/35 (51%)
		WD40 repeat	320..357	CDD:293791	15/38 (39%)
		WD40 repeat	364..400	CDD:293791	15/38 (39%)
		WD40 repeat	407..441	CDD:293791	12/46 (26%)
AAAS	XP_011537080.1	WD40	<133..343	CDD:295369	78/216 (36%)
		WD40	154..>413	CDD:225201	96/266 (36%)
		WD40 repeat	157..193	CDD:293791	15/37 (41%)
		WD40 repeat	197..243	CDD:293791	11/45 (24%)
		WD40 repeat	247..283	CDD:293791	12/35 (34%)
		WD40 repeat	291..328	CDD:293791	20/41 (49%)
		WD40 repeat	356..390	CDD:293791	7/33 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158866
Domainoid	1	1.000	78	1.000	Domainoid score	I8844
eggNOG	1	0.900	-	-		E1_KOG2139
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H9232
Inparanoid	1	1.050	188	1.000	Inparanoid score	I3914
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49996
OrthoDB	1	1.010	-	-		D470197at33208
OrthoFinder	1	1.000	-	-		FOG0005612
OrthoInspector	1	1.000	-	-		oto89111
orthoMCL	1	0.900	-	-		OOG6_104613
Panther	1	1.100	-	-	LDO	PTHR14494
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5823
SonicParanoid	1	1.000	-	-		X5253
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800