DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Aladin and Aaas

DIOPT Version :9

Sequence 1:	NP_001285049.1	Gene:	Aladin / 31881	FlyBaseID:	FBgn0030122	Length:	466	Species:	Drosophila melanogaster
Sequence 2:	XP_008763926.1	Gene:	Aaas / 300259	RGDID:	1308701	Length:	560	Species:	Rattus norvegicus

Alignment Length:	449	Identity:	136/449 - (30%)
Similarity:	209/449 - (46%)	Gaps:	32/449 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 PQINLNSELLANPAGQRYYGGQ-SFVSVNEGVLKRIARSFFNGGFWKTLEEARSPETREQAPLIA 96
            |.::|..:.|..| |:..:|.: :|:...|.|.||....:.:.|.:..|.|..:.| .|....:.
  Rat    60 PVLHLTKDPLKAP-GRLDHGTRAAFIHHREQVWKRCINVWHDVGLFGVLNEIANSE-EEVFEWVK 122

  Fly    97 QAGDLIAQFLGLATGLR--ILPHTQQLSAERIAQFVETRDWLNSDVRYLAWNQHFFCLAVAGVDD 159
            .|........|.|:.|.  :.||....|.:.||:|.:..:|.:..:|..||:.|....|||.:||
  Rat   123 TASSWALALCGRASSLHGSLFPHLSLRSEDLIAEFAQVTNWSSCCLRVFAWHPHTNKFAVALLDD 187

  Fly   160 VVRIYTKSSSATTATVLKSPSQTQITCMAWRPLCASEIVIGCRQGLCFWEVDST-LHLGRTNAPS 223
            .:|:|  ::::|....||...|..:..:||:||.||.:.:.|:..:..|.:|.| |....::..:
  Rat   188 SIRVY--NANSTIVPSLKHRLQRNVAALAWKPLSASVLAVACQSCILIWTLDPTSLSTRPSSGCA 250

  Fly   224 EIFKYPNNLPITSMQWNKDGTQLATASIGDRSIIIWQPDTGMMQPLK--RLGPPGSLLKWSPDND 286
            ::..:|.:.|:||:.|..:|..|.:||..|..|::|...|....||.  |.|...:|| ||||..
  Rat   251 QVLSHPGHTPVTSLAWAPNGGWLLSASPVDAVILVWDVSTETCVPLPWFRGGGVTNLL-WSPDGS 314

  Fly   287 WLFAATVDRVFRVWNCHQQWTTERWVCGP--GGYVQTACWSPCGRFLLFVSSAEPILYRLQFVQQ 349
            .:.|.|...|||||.. :.||.|.|   |  .|..||.||||.|:.|||....|.::|.|.|.:.
  Rat   315 KVLATTPSAVFRVWEA-RMWTCEGW---PTLSGRCQTGCWSPDGKRLLFTVLGEALIYSLSFPEP 375

  Fly   350 SLLSSS--ADEKEILPIADLNACSI---DANRTLVGGPAQQLAWDPHGNYLVVTFKATNCIAVFR 409
            ......  ...|....:|||:..:|   |....| ||.|..:.|||.|..|.|..|....:....
  Rat   376 CGTEKGHVGGAKSATIVADLSETTIQTPDGEERL-GGEAHAMVWDPSGERLAVLMKGNPRVQDGN 439

  Fly   410 TFIQKFDLQISAAYYL------SGETAAEHPSFICFQPLYEDNDRSVLTIAWSSGRIQY 462
            ..|..|..:.|..:.|      .||..|: ...:.|.|.:  |..::|::.||:|||.:
  Rat   440 PVILLFRTRNSPVFELLPCGVIQGEPGAQ-AQLVSFHPAF--NKGALLSVCWSTGRITH 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aladin	NP_001285049.1	WD40	<130..>420	CDD:225201	96/299 (32%)
		WD40 repeat	137..177	CDD:293791	12/39 (31%)
		WD40 repeat	184..227	CDD:293791	11/43 (26%)
		WD40 repeat	235..274	CDD:293791	14/40 (35%)
		WD40 repeat	276..312	CDD:293791	16/35 (46%)
		WD40 repeat	320..357	CDD:293791	14/38 (37%)
		WD40 repeat	364..400	CDD:293791	15/38 (39%)
		WD40 repeat	407..441	CDD:293791	8/39 (21%)
Aaas	XP_008763926.1	WD40	168..>358	CDD:225201	69/196 (35%)
		WD40	169..>382	CDD:295369	76/219 (35%)
		WD40 repeat	171..207	CDD:293791	13/37 (35%)
		WD40 repeat	211..257	CDD:293791	11/45 (24%)
		WD40 repeat	261..297	CDD:293791	12/35 (34%)
		WD40 repeat	305..342	CDD:293791	18/41 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352865
Domainoid	1	1.000	42	1.000	Domainoid score	I12126
eggNOG	1	0.900	-	-		E1_KOG2139
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H9232
Inparanoid	1	1.050	181	1.000	Inparanoid score	I3889
OMA	1	1.010	-	-		QHG49996
OrthoDB	1	1.010	-	-		D470197at33208
OrthoFinder	1	1.000	-	-		FOG0005612
OrthoInspector	1	1.000	-	-		oto96240
orthoMCL	1	0.900	-	-		OOG6_104613
Panther	1	1.100	-	-	LDO	PTHR14494
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5253
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.770