DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Aladin and aaas

DIOPT Version :9

Sequence 1:	NP_001285049.1	Gene:	Aladin / 31881	FlyBaseID:	FBgn0030122	Length:	466	Species:	Drosophila melanogaster
Sequence 2:	XP_002936677.1	Gene:	aaas / 100485071	XenbaseID:	XB-GENE-967146	Length:	519	Species:	Xenopus tropicalis

Alignment Length:	469	Identity:	142/469 - (30%)
Similarity:	217/469 - (46%)	Gaps:	58/469 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 LERYPQINLNSELLANPAGQRYYGGQSFVSVNEGVLKRIARSFFNGGFWKTLEEARSPETREQAP 93
            |...|::.:..:.:..|.........:|:...|.:.||...::.|.|....|||..:  ::|:.|
Frog    42 LVNIPELTIPIDAVKAPGRMELSSKTAFIHHKESIWKRCLNAWHNVGLAGFLEEMSN--SKEEVP 104

  Fly    94 ----LIAQAGDLIAQFLGLATGLRILPHTQQLSAERIAQFVETRDWLNSDVRYLAWNQHFFCLAV 154
                .:|:....:.:.:....| .:.||....|.:..|:|.:..||.:|.:|..||:.|....|:
Frog   105 PWLCHVARCSLAVCRSVSSLHG-SLFPHLTMKSEDLTAEFSQALDWADSPLRAFAWHPHTNKFAL 168

  Fly   155 AGVDDVVRIYTKSSSATTATVLKSPSQTQITCMAWRPLCASEIVIGCRQGLCFWEVDST-LHLGR 218
            |.:||.:||||..|  .|...||...|..:..|||:|:|||.:.:.|:..:..|.||.| |....
Frog   169 ALLDDSIRIYTAGS--PTIPTLKHRLQKDVASMAWKPMCASVLAVACQSCVLVWHVDPTSLSTRP 231

  Fly   219 TNAPSEIFKYPNNLPITSMQWNKDGTQLATASIGDRSIIIWQPDTGMMQPLKRLGPPG-SLLKWS 282
            ::..:::..:|.:.|:||:.|:..|..|.:||..|.::::|...|....||:|:|..| :.|.||
Frog   232 SSGCAQVLSHPGHSPVTSVCWSPKGGVLLSASPVDTAMLVWDVPTESCIPLQRVGGGGVTFLSWS 296

  Fly   283 PDNDWLFAATVDRVFRVWNCHQQWTTERWVCGP--GGYVQTACWSPCGRFLLFVSSAEPILYRLQ 345
            ||...:.|||...|||||.. |:||.|||   |  .|..||.||||.|..|||....|.::|.|.
Frog   297 PDGSKVLAATPSCVFRVWET-QKWTCERW---PTLQGRCQTGCWSPDGSRLLFAVKGESVIYSLC 357

  Fly   346 F-----VQQSLLSSSADEKEILPIADLNACSIDANRTLVGGPAQQLAWDPHGNYLVVTFK----- 400
            |     ..|:.:..|.....:..:::: ..:..|....|||..|.:.|||.|..|.|..|
Frog   358 FSVSEGETQAGVGGSQSATVVADVSEV-VFTTSAGEIRVGGDIQSMCWDPSGERLAVLLKGNPEF 421

  Fly   401 --ATNCIAVFRT------------FIQKFDLQISAAYYLSGETAAEHPSFICFQPLYEDNDRSVL 451
              :...||||||            |||.          ..|||    |....|.|.:...  ::|
Frog   422 EESQPVIAVFRTRNSPIFELLPCGFIQG----------RKGET----PQLFQFHPGFHKG--ALL 470

  Fly   452 TIAWSSGRIQYYAF 465
            :..|||||:.::.|
Frog   471 SELWSSGRVNHFPF 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aladin	NP_001285049.1	WD40	<130..>420	CDD:225201	108/317 (34%)
		WD40 repeat	137..177	CDD:293791	15/39 (38%)
		WD40 repeat	184..227	CDD:293791	13/43 (30%)
		WD40 repeat	235..274	CDD:293791	13/38 (34%)
		WD40 repeat	276..312	CDD:293791	19/36 (53%)
		WD40 repeat	320..357	CDD:293791	16/41 (39%)
		WD40 repeat	364..400	CDD:293791	11/35 (31%)
		WD40 repeat	407..441	CDD:293791	12/45 (27%)
aaas	XP_002936677.1	WD40	152..413	CDD:392136	95/267 (36%)
		WD40 repeat	155..190	CDD:293791	15/36 (42%)
		WD40 repeat	196..240	CDD:293791	13/43 (30%)
		WD40 repeat	248..286	CDD:293791	13/37 (35%)
		WD40 repeat	290..328	CDD:293791	20/41 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	71	1.000	Domainoid score	I9325
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H9232
Inparanoid	1	1.050	200	1.000	Inparanoid score	I3664
OMA	1	1.010	-	-		QHG49996
OrthoDB	1	1.010	-	-		D470197at33208
OrthoFinder	1	1.000	-	-		FOG0005612
OrthoInspector	1	1.000	-	-		oto102966
Panther	1	1.100	-	-	LDO	PTHR14494
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5823
SonicParanoid	1	1.000	-	-		X5253
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.110