DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cfp1 and E(bx)

DIOPT Version :9

Sequence 1:	NP_572556.1	Gene:	Cfp1 / 31880	FlyBaseID:	FBgn0030121	Length:	663	Species:	Drosophila melanogaster
Sequence 2:	NP_001261188.1	Gene:	E(bx) / 44811	FlyBaseID:	FBgn0000541	Length:	2761	Species:	Drosophila melanogaster

Alignment Length:	701	Identity:	148/701 - (21%)
Similarity:	234/701 - (33%)	Gaps:	214/701 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 KYKKTVSFTRCTAIIFL----TTKEVSKQKEEIRREIAREFDLPERKSKIATILKQEDQAYCICR 66
            :|.:..|:.|...:|.|    |.:||:..:..:|:....|...|           .|.|.
  Fly  1377 RYGEKTSYLRRKVVIPLEMPKTVREVTSIRSGLRKRKRAESPQP-----------TEPQI----- 1425

  Fly    67 SSDCSRFMIGCDGCEEWYHGDCIGITEKEAKHIKQYYCRRCKKENPELQTIFRLVATER--AAAS 129
                         .|||...|.:.:.  |.|.:.:      |:|...|..:.|.||:.:  |:.|
  Fly  1426 -------------TEEWVDEDKLELW--EIKFMGE------KQEKARLSAVTRSVASRQLEASGS 1469

  Fly   130 NAASTSLN-APGV-GPSGAAPAAAPVASATTSQQAPPPTTAAAKRKNSSARE------PKMGKRC 186
            |.::||.| |.|| |....||..:........||.........:||..:..|      |..|:..
  Fly  1470 NGSNTSTNGALGVAGRVQLAPKLSEDVKEKMEQQLKLQRAVHQQRKLVATGEITRSVTPVKGQVI 1534

  Fly   187 GTCEGCRRPNCNQCDACRVRVGHKPRCIFRTCVVQAATVLKESQATQAGPSRKREKAAPK----S 247
            |:    ||......|.             .|.::|.|.    :|.::.|.:.....||..    |
  Fly  1535 GS----RRVIVKNPDG-------------TTRIIQQAV----TQVSRTGGANTAAAAASPTVGGS 1578

  Fly   248 RNVQVGPRAASPEIFLNPELQGIRQCYGPNCCSHARPQSKYCSDKCGFNLATKRIFQVLPQRLQE 312
            .:.|..|..::|.     ::|.||   ||:.....|          |.| ..:::.|:...:|..
  Fly  1579 TSTQSNPSTSTPH-----KVQIIR---GPDGKVSVR----------GLN-PGQQLVQMPDGKLHV 1624

  Fly   313 WNLTPSRAAEETRKHLDNIRHKQSLVRFALAELEKRSEELNMVVERAKRSSIDTLGSQDTADMED 377
            ...|.|                        :....:..::.:.::.|..||...:.|..|....
  Fly  1625 LTTTTS------------------------SNSAGQGNKMKVPIKPASTSSSPAISSAQTTTNP- 1664

  Fly   378 EQSMYCITCGHEIHSRTAIKHMEKCFNKYESQASFGSIFKTRMEGNNMFCDFYNPASKTYCKRLR 442
                  :|   .:..:.|:||:.|                             |.|:::.....|
  Fly  1665 ------VT---PVIKQIAVKHVTK-----------------------------NSATQSIASSSR 1691

  Fly   443 VLCP----------------EHSKDP------------KVNDTDVCGSPLVNNVFNPTGEFCRAP 479
            |..|                ..|..|            ||.:|...|..| ..||..:|.
  Fly  1692 VALPLAQIKNKLLLAQQQQQSTSSSPATSSSPVQKIVSKVVNTSTSGQTL-QQVFVQSGS----- 1750

  Fly   480 KKNCFKHYAWEKIRRAEIDLERVRQWLKMDDLMEQERVMRQQLTSRANLLGL-MLHSTYNHEVMD 543
            |....::...:|:    |......|......:.:|:.|..|.:......:.: .:.:....:|:.
  Fly  1751 KLVVGQNAQGQKV----IISTSAAQQQGTSPVQQQQLVQSQPIQQSPQQISMTQVGNQPTQKVIQ 1811

  Fly   544 ELVRK---QQEHLVEFEKQRRRLAHQQQIQTQQKQYQEKQKLMLQQQQQQQQQQQQQQQQQQQQQ 605
            ::|..   ||:.:|  ..||..|:..|.|.||:...|       .|..|..|||.|.||||||..
  Fly  1812 QIVNTSNVQQQIVV--GGQRIILSPGQTIVTQRNVPQ-------SQALQMVQQQIQTQQQQQQHH 1867

  Fly   606 LQQPQQQQQQQQQQQQEQQQLQLKPHHLQQLQLQLLQQQQKKAQIPQKTQI 656
            :.||     |||...|..|.:|..|....:|..||:.|||.:..|.:||||
  Fly  1868 VVQP-----QQQFVVQSNQIVQSSPSAQTKLVKQLVVQQQSQQTIEEKTQI 1913

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cfp1	NP_572556.1	PHD_Cfp1	62..107	CDD:277028	6/44 (14%)
		zf-CXXC	178..218	CDD:251032	7/45 (16%)
		zf-CpG_bind_C	300..532	CDD:289071	36/260 (14%)
E(bx)	NP_001261188.1	DDT	190..245	CDD:280886
		WHIM1	288..337	CDD:292246
		PHD1_BPTF	341..383	CDD:277034
		BAH	361..>438	CDD:295389
		TNG2	<2423..2638	CDD:227367
		PHD_SF	2533..2579	CDD:304600
		PHD2_3_BPTF	2589..2635	CDD:277035
		Bromo_gcn5_like	2653..2752	CDD:99941
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1632
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900