DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cfp1 and Dido1

DIOPT Version :9

Sequence 1:	NP_572556.1	Gene:	Cfp1 / 31880	FlyBaseID:	FBgn0030121	Length:	663	Species:	Drosophila melanogaster
Sequence 2:	XP_006235867.1	Gene:	Dido1 / 362286	RGDID:	1311173	Length:	2258	Species:	Rattus norvegicus

Alignment Length:	753	Identity:	135/753 - (17%)
Similarity:	227/753 - (30%)	Gaps:	309/753 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 LTTKEVSKQKEEIRREIAREFDLPERKSKIATILKQEDQAYCICRSSDCSRFMIGCDGCEEWYHG 86
            |..|.....|||..||..:    |:.:.::    ...:..|||||....:||||.||.||||:||
  Rat   235 LEGKATQGSKEESPREAGK----PKPECEV----YDPNALYCICRQPHNNRFMICCDRCEEWFHG 291

  Fly    87 DCIGITEKEAKHIKQ----YYCRRCKKENPELQTIFRLVATERAAASNAASTSLNAPGVGPSGAA 147
            ||:||:|...:.:::    |.|..|        ||.::          ...||
  Rat   292 DCVGISEARGRLLERNGEDYICPNC--------TILQV----------QDETS------------ 326

  Fly   148 PAAAPVASATTSQQAPPPTTAAAKRKNSSAREPKMGKRCGTCEGCRRPNCNQCDACRVRVGHKPR 212
                  :||...|.|                            |||....:..|...:
  Rat   327 ------SSAADEQDA----------------------------GCRPVGADGTDCTSI------- 350

  Fly   213 CIFRTCVVQAATVLKESQATQAGPSRKREKAAPKSRNVQVGPRAASPEIFLNPELQGIRQCYGPN 277
                      .||.:.|...| |...:.||||..|...::  :...|.:    |..|..:|.||.
  Rat   351 ----------GTVEQRSGEDQ-GIKGRIEKAANPSGKKKL--KIFQPVV----EAPGAAKCIGPG 398

  Fly   278 CCSHARPQSKYCSDKCGFN--LATKRIF----QVLPQRLQEWNLTP------------------- 317
            |.:.|:|.|.|||:.|...  .||.:|.    :..|:..::..:.|
  Rat   399 CSNVAQPDSVYCSNDCILKHAAATMKILSSGKEQKPKPKEKVKMKPEKFSLPKCSVQAGIKISSV 463

  Fly   318 -SRAAEETR----KHLDNIRHKQSLVRFALAEL-------------------------------- 345
             .|.|.|.|    |.:......::.|:.|..|.
  Rat   464 HKRLASEKRENPVKKVTLASRSETSVKEATCESTPSWASDHNYNAVKPEKPEKPEKPTALSPTLL 528

  Fly   346 ------EKRSEELNMVVERAKRSSI---DTLGSQDTAD--MEDEQSMYCITCGHEIHSRTAIKHM 399
                  :||.|:..:......:.::   ..:|.|.:..  :..:...|....|    ::||:|.:
  Rat   529 SKSMKDDKRVEDRTVAAAAVPKKAVPPGSVMGRQTSPRNLVPKKLPPYPNMAG----AKTAVKKL 589

  Fly   400 EKCF-------------------------------NKYESQASFGSIFKTRMEGNNMFCDFYNPA 433
            ...|                               .|....|:...|.:..|..|       .||
  Rat   590 PSGFKGTIPKRPWPSATLSGTSARQAGPTPVIAASKKLPGSAAVVGIARKPMSAN-------VPA 647

  Fly   434 SKTYCKRLRVLCPEHSKDPKVNDTDVCGSPLVNNVFNPTGEFCRAPKKNCFKHYAWEKIRRAEID 498
            :.....||..:.|..|:.         .|.:..|:            :...|...|:::..:
  Rat   648 ASPVPGRLGPVSPAPSQP---------NSQIRQNI------------RRSLKEILWKRVNDS--- 688

  Fly   499 LERVRQWLKMDDLMEQERVMRQQLTSRANLLG-LMLHSTYNHEVMDELVRKQQEHLVEFEKQRRR 562
                      |||:..|           |.:| :.||                     .||:...
  Rat   689 ----------DDLIMTE-----------NEVGKIALH---------------------IEKEMFN 711

  Fly   563 LAHQQQIQTQQKQYQEKQKLMLQQQQQQQQQQQQQQQQQQQQQLQQPQQQQQQQQQQQQE---QQ 624
            |     .|....:|:.|.:.::                   ..|:.|:.|....:..::|   .:
  Rat   712 L-----FQVTDNRYKSKYRSIM-------------------FNLKDPKNQGLFHRVLREEISLAK 752

  Fly   625 QLQLKPHHLQQLQLQLLQQQQKKAQIPQKTQIIYLQKK 662
            .:::||..|...:|.:..::..|:.|..:|:::...||
  Rat   753 LVRMKPEELVSKELSMWTEKPTKSVIESRTKLLNESKK 790

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cfp1	NP_572556.1	PHD_Cfp1	62..107	CDD:277028	24/48 (50%)
		zf-CXXC	178..218	CDD:251032	4/39 (10%)
		zf-CpG_bind_C	300..532	CDD:289071	43/334 (13%)
Dido1	XP_006235867.1	TNG2	<157..299	CDD:227367	29/71 (41%)
		PHD_DIDO1_like	263..316	CDD:277109	24/52 (46%)
		TFS2M	671..772	CDD:128786	25/181 (14%)
		SPOC	1046..1194	CDD:400205
		SWIRM-assoc_1	<1465..1502	CDD:406808
		PHA03247	<1564..2085	CDD:223021
		SF-CC1	2144..>2182	CDD:273721
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1632
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900