DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cfp1 and DIDO1

DIOPT Version :9

Sequence 1:	NP_572556.1	Gene:	Cfp1 / 31880	FlyBaseID:	FBgn0030121	Length:	663	Species:	Drosophila melanogaster
Sequence 2:	XP_011526806.1	Gene:	DIDO1 / 11083	HGNCID:	2680	Length:	2276	Species:	Homo sapiens

Alignment Length:	817	Identity:	164/817 - (20%)
Similarity:	259/817 - (31%)	Gaps:	297/817 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 SKQKEEIRREIAREFDLPERKSKI----ATILKQEDQA-----------------YCICRSSDCS 71
            |||:.|..:.:..:....:|:||:    |..:|.|:..                 |||||....:
Human   215 SKQEPENDQGVVSQAGKDDRESKLEGKAAQDIKDEEPGDLGRPKPECEGYDPNALYCICRQPHNN 279

  Fly    72 RFMIGCDGCEEWYHGDCIGITEKEAKHIKQ----YYCRRCKKENPELQTIFRLVATERAAASNAA 132
            ||||.||.||||:||||:||:|...:.:::    |.|..|        ||.:
Human   280 RFMICCDRCEEWFHGDCVGISEARGRLLERNGEDYICPNC--------TILQ------------- 323

  Fly   133 STSLNAPGVGPSGAAPAAAPVASATTSQQAPPPTTAAAKRKNSSAREPKMGKRCGTCEGCRRPNC 197
                                |...|.|:.|             ..:|.|.  |.|..:|
Human   324 --------------------VQDETHSETA-------------DQQEAKW--RPGDADG------ 347

  Fly   198 NQCDACRVRVGHKPRCIFRTCVVQAATVLKESQATQAGPSRKREKAA-----PKSRNVQVGP--- 254
                               |......|:.::|...| |...:.||||     .|.:..|.||
Human   348 -------------------TDCTSIGTIEQKSSEDQ-GIKGRIEKAANPSGKKKLKIFQPGPGPV 392

  Fly   255 ----------------RAASPEIFLN------PELQGIRQCYGPNCCSHARPQSKYCSDKCGFN- 296
                            |:.|....|:      .|..|..:|.||.||..|:|.|.|||:.|...
Human   393 PTQLPVLWQVLEIAVSRSISAFTLLHCISCKVIEAPGASKCIGPGCCHVAQPDSVYCSNDCILKH 457

  Fly   297 -LATKRIF----QVLPQRLQEWNLTPS-----RAAEETRKHLDNI------RHKQSLVRFALAEL 345
             .||.:..    :..|:..::..:.|.     :...:....:.::      ..|::.|:.|:. :
Human   458 AAATMKFLSSGKEQKPKPKEKMKMKPEKPSLPKCGAQAGIKISSVHKRPAPEKKETTVKKAVV-V 521

  Fly   346 EKRSEELNMVVERAKRSSIDTLGSQDTADMEDEQSMYCITCGHEIHSRTAIKHMEKCF------- 403
            ..|||.|..  |.|..||..:..|.                    |:..|:| .||..
Human   522 PARSEALGK--EAACESSTPSWASD--------------------HNYNAVK-PEKTAAPSPSLL 563

  Fly   404 --------NKYESQASFGSIFKTRMEGN---------NMF---CDFYN-----PASKTYCKRLRV 443
                    ...|..|:..:..||...|:         |:.   ..|.|     ||.|......:.
Human   564 YKSTKEDRRSEEKAAAMAASKKTAPPGSAVGKQPAPRNLVPKKSSFANVAAATPAIKKPPSGFKG 628

  Fly   444 LCPEHSKDPKVNDTDVCG------------------------SPLVNNVFNPT------------ 472
            ..|   |.|.::.|...|                        :.||..|..|.
Human   629 TIP---KRPWLSATPSSGASAARQAGPAPAAATAASKKFPGSAALVGAVRKPVVPSVPMASPAPG 690

  Fly   473 --GEFCRAPKKNCFKHYAWEKIRRA--EIDLERVRQWLKMDDL-------------MEQERVMRQ 520
              |....||.:.  .....:.|||:  ||..:||..   .|||             :|:|.....
Human   691 RLGAMSAAPSQP--NSQIRQNIRRSLKEILWKRVND---SDDLIMTENEVGKIALHIEKEMFNLF 750

  Fly   521 QLTS-------RANLLGL-------MLHSTYNHEV-MDELVRKQQEHLV--EFEKQRRRLAHQQQ 568
            |:|.       |:.:..|       :.|.....|: :.:|||.:.|.||  |....:.|.| :..
Human   751 QVTDNRYKSKYRSIMFNLKDPKNQGLFHRVLREEISLAKLVRLKPEELVSKELSTWKERPA-RSV 814

  Fly   569 IQTQQKQYQEKQKLMLQQQ---QQQQQQQQQQQQQQQQQQLQQPQQQQQQQQQQQQEQQQLQLKP 630
            ::::.|.:.|.:|...:|:   ..:........::||:.....|::.............:.....
Human   815 MESRTKLHNESKKTAPRQEAIPDLEDSPPVSDSEEQQESARAVPEKSTAPLLDVFSSMLKDTTSQ 879

  Fly   631 H--HLQQLQLQLLQQQQKKAQ---IPQKTQIIYLQKK 662
            |  ||..|..::...|...|:   .|:|.::....||
Human   880 HRAHLFDLNCKICTGQVPSAEDEPAPKKQKLSASVKK 916

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cfp1	NP_572556.1	PHD_Cfp1	62..107	CDD:277028	24/48 (50%)
		zf-CXXC	178..218	CDD:251032	5/39 (13%)
		zf-CpG_bind_C	300..532	CDD:289071	58/345 (17%)
DIDO1	XP_011526806.1	TNG2	<160..302	CDD:227367	31/86 (36%)
		PHD_DIDO1_like	266..319	CDD:277109	24/52 (46%)
		TFS2M	708..809	CDD:128786	25/103 (24%)
		SPOC	1093..1199	CDD:285043
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1632
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900