DRSC/TRiP Functional Genomics Resources

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Protein Alignment HNRNPH2 and glo

DIOPT Version :9

Sequence 1:NP_001027565.1 Gene:HNRNPH2 / 3188 HGNCID:5042 Length:449 Species:Homo sapiens
Sequence 2:NP_650120.1 Gene:glo / 41431 FlyBaseID:FBgn0259139 Length:586 Species:Drosophila melanogaster


Alignment Length:569 Identity:165/569 - (28%)
Similarity:249/569 - (43%) Gaps:198/569 - (34%)


- Green bases have known domain annotations that are detailed below.


Human    13 VKVRGLPWSCSADEVMRFFSDCKIQNGTSGIRFIYTR-EGRPSGEAFVELESEEEVKLALKKDRE 76
            |::||||||.:..|::.|..:..:.||::||..:.:| :|:.:|||:||:.|:|:|:.|.|.::.
  Fly    51 VRLRGLPWSATHKEILDFLENVNVTNGSAGIHLVTSRVDGKNTGEAYVEVASQEDVEEARKLNKA 115

Human    77 TMGHRYVEVFKSNSVEMDWVLKHTGPNSPDTANDGFVRLRGLPFGCSKEEIVQFFSGLEIVPN-- 139
            :|||||:|||.:...|....::....:.  ||  ..|:|||||:..::::|.:|||||:|..:  
  Fly   116 SMGHRYIEVFTATPKEAKEAMRKISGHG--TA--FVVKLRGLPYAVTEQQIEEFFSGLDIKTDRE 176

Human   140 GMTLPVDFQGRSTGEAFVQFASQEIAEKALKKHKERIGHRYIEIFKSSRAEVRTHYDPPRKLMA- 203
            |:...:|.:||:||||||||.||:..|:||.:::|:|||||||||:||.||::      |...| 
  Fly   177 GILFVMDRRGRATGEAFVQFESQDDTEQALGRNREKIGHRYIEIFRSSIAEMK------RATGAG 235

Human   204 ---MQRPGPYD--RPGAGRGYNSIGRG-----------------AGFER----MRRGAYGGGYGG 242
               ..||||||  ..||.||.|..|.|                 .||..    |..|.:|...||
  Fly   236 GGVGGRPGPYDIRDRGANRGGNDFGGGRNDWGNNGNFGVGANNMLGFNNLPSLMNSGNFGNNQGG 300

Human   243 -------------YDDYGGYNDG---YGFGSD--------RFGRDLNYCFSGMSD---------- 273
                         :.::||.|:|   ..||:|        .||.:....|.|.::          
  Fly   301 NNGNFGNNSGPSNFGNFGGGNNGGNSGNFGNDSGNSGNFGNFGNNGGGNFGGNNNGGGGFNSGNN 365

Human   274 -------HRYGDGGSS---------------FQSTTG---------------------------- 288
                   :.:|:.|.|               |.|::|                            
  Fly   366 FNSPGGVNNFGNNGGSNFGGNGGGGFNNGGNFVSSSGVGNFGPIGGGRNNNNGNFGNSGFGNFGG 430

Human   289 --------------------------------------------------HCVHMRGLPYRATEN 303
                                                              :.:|||||||.:.||
  Fly   431 NNNVGSNFGGGNNGGGGGFNNGSNFGGGNSMGGGGNFGPIGGGRGNDIEYYTIHMRGLPYTSFEN 495

Human   304 DIYNFFSPLNPMRVHIEIGPDGRVTGEADVEFATHEDAVAAMAKDKANMQHRYVELFLN-STAGT 367
            |::.||.|:.|..|.|.....|..:|.||..|.|:||:..||.:.:..|..||:|||.: .|.|.
  Fly   496 DVFKFFEPIRPANVRINYNKKGLHSGTADAYFDTYEDSQVAMKRHREQMGSRYIELFYDGKTRGL 560

Human   368 SGGAYDHSYVELFLNSTAGASGGAYGSQMMGGMGLSNQSSYGGPASQQL 416
            :||.:            .|.:||       ||||    ::.||..|:::
  Fly   561 NGGEH------------GGGNGG-------GGMG----NNGGGNFSRRI 586

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HNRNPH2NP_001027565.1 RRM1_hnRNPH_hnRNPH2_hnRNPF 10..88 CDD:410128 33/75 (44%)
RRM2_hnRNPH_hnRNPH2_hnRNPF 103..192 CDD:410130 46/90 (51%)
2 X 16 AA Gly-rich approximate repeats 234..433 67/318 (21%)
zf-RNPHF 257..290 CDD:369688 11/150 (7%)
RRM3_hnRNPH_hnRNPH2_hnRNPF 289..364 CDD:410133 32/75 (43%)
2 X 19 AA perfect repeats 354..392 12/38 (32%)
gloNP_650120.1 RRM_SF 51..125 CDD:302621 31/73 (42%)
RRM2_hnRNPH_like 146..224 CDD:240948 40/77 (52%)
RRM3_hnRNPH_CRSF1_like 481..555 CDD:240950 32/73 (44%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 78 1.000 Domainoid score I8778
eggNOG 1 0.900 - - E1_KOG4211
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 243 1.000 Inparanoid score I3313
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D392876at33208
OrthoFinder 1 1.000 - - FOG0000855
OrthoInspector 1 1.000 - - otm42118
orthoMCL 1 0.900 - - OOG6_102542
Panther 1 1.100 - - O PTHR13976
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4231
SonicParanoid 1 1.000 - - X436
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
1110.900

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