Protein Alignment CG31548 and HSD17B14

DIOPT Version :10

• Sequence 1: NP_730974.1
• Gene: CG31548 / 318794
• FlyBaseID: FBgn0051548
• Length: 256
• Species: Drosophila melanogaster
• Sequence 2: NP_057330.2
• Gene: HSD17B14 / 51171
• HGNCID: 23238
• Length: 270
• Species: Homo sapiens
• Alignment Length: 256
• Identity: 89/256 - (34%)
• Similarity: 130/256 - (50%)
• Gaps: 23/256 - (8%)

  Fly     3 FAGKVVLITGASSGIGAATAIKFAKYGACLAL------NGRNVENLKKVAAECSKVSQSQP--AL 59
            :|||||::||...||||.....|...||.:.:      .||.:|             |..|  ..
Human     7 YAGKVVVVTGGGRGIGAGIVRAFVNSGARVVICDKDESGGRALE-------------QELPGAVF 58

  Fly    60 VVGDIAKEADTQRIWSETLQQYGKLDVLVNNAG-IIETGTIETTSLEQYDRVMNTNLRAIYHLTM 123
            ::.|:.:|.|.:.:.|||::::|:||.:||||| .......|.||.:.:.:::..||...|.||.
Human    59 ILCDVTQEDDVKTLVSETIRRFGRLDCVVNNAGHHPPPQRPEETSAQGFRQLLELNLLGTYTLTK 123

  Fly   124 LATPELVKTKGNIVNVSSVNGIRSFPGVLAYNISKMGVDQFTRCVALELAAKGVRVNCVNPGVTV 188
            ||.|.|.|::||::|:||:.|.......:.|..:|..|...|:.:||:.:..||||||::||...
Human   124 LALPYLRKSQGNVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPYGVRVNCISPGNIW 188

  Fly   189 TNLHARGGMDAETYKKFLEHSKTTHALGRPGDVKEVAAAIAFLASDEASFSTGVSLPVDGG 249
            |.|...........:..:........|||.|...||.||..|||| ||:|.||:.|.|.||
Human   189 TPLWEELAALMPDPRATIREGMLAQPLGRMGQPAEVGAAAVFLAS-EANFCTGIELLVTGG 248

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31548	NP_730974.1	Rossmann-fold NAD(P)(+)-binding proteins	3..253	CDD:473865	89/256 (35%)
HSD17B14	NP_057330.2	RDH_SDR_c	1..256	CDD:187638	89/256 (35%)