Protein Alignment CG31548 and RDH8

DIOPT Version :10

• Sequence 1: NP_730974.1
• Gene: CG31548 / 318794
• FlyBaseID: FBgn0051548
• Length: 256
• Species: Drosophila melanogaster
• Sequence 2: NP_056540.3
• Gene: RDH8 / 50700
• HGNCID: 14423
• Length: 311
• Species: Homo sapiens
• Alignment Length: 265
• Identity: 74/265 - (27%)
• Similarity: 114/265 - (43%)
• Gaps: 49/265 - (18%)

  Fly     1 MNFAGKVVLITGASSGIGAATAIKFA-----KYGACLALN--GRNVENLKKVAAECSKVSQSQPA 58
            |..|.:.|||:|.|||||...|::.|     :|.....:.  |:. |.|:..|.|
Human     1 MAAAPRTVLISGCSSGIGLELAVQLAHDPKKRYQVVATMRDLGKK-ETLEAAAGE---------- 54

  Fly    59 LVVGDIAKEADTQRIWSETLQQ-----YGKLDVLVNNAGIIETGTIETTSLEQYDRVMNTNLRAI 118
             .:|.....|.......|::.|     .|::||||||||:...|.:|..||.....|.:||....
Human    55 -ALGQTLTVAQLDVCSDESVAQCLSCIQGEVDVLVNNAGMGLVGPLEGLSLAAMQNVFDTNFFGA 118

  Fly   119 YHLTMLATPELVKTK-GNIVNVSSVNGIRSFPGVL---AYNISKMGVDQFTRCVALELAAKGVRV 179
            ..|.....|.:.:.: |:||.:|||.|::   ||:   .|..||..::.|...:|::|....:.:
Human   119 VRLVKAVLPGMKRRRQGHIVVISSVMGLQ---GVIFNDVYAASKFALEGFFESLAIQLLQFNIFI 180

  Fly   180 NCVNPGVTVTNLHAR----------GGMDAETYKKFLE-----HSKTTHALGR-PGDVKEVAAAI 228
            :.|.||..||....:          .|.|.||...|.:     ..|...::|: |.||  |.|.:
Human   181 SLVEPGPVVTEFEGKLLAQVSMAEFPGTDPETLHYFRDLYLPASRKLFCSVGQNPQDV--VQAIV 243

  Fly   229 AFLAS 233
            ..::|
Human   244 NVISS 248

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31548	NP_730974.1	Rossmann-fold NAD(P)(+)-binding proteins	3..253	CDD:473865	73/263 (28%)
RDH8	NP_056540.3	type1_17beta-HSD-like_SDR_c	6..262	CDD:187666	72/260 (28%)