DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31548 and HSD11B1L

DIOPT Version :9

Sequence 1:	NP_730974.1	Gene:	CG31548 / 318794	FlyBaseID:	FBgn0051548	Length:	256	Species:	Drosophila melanogaster
Sequence 2:	NP_001254797.1	Gene:	HSD11B1L / 374875	HGNCID:	30419	Length:	333	Species:	Homo sapiens

Alignment Length:	242	Identity:	68/242 - (28%)
Similarity:	102/242 - (42%)	Gaps:	17/242 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 GKVVLITGASSGIGAATAIKFAKYGACLALNGRNVENLKKVAAECSKVSQSQPALVVGDIAKEAD 69
            |..||:|||::|:|...|..:|:.|:.|.|.......|:||...|.|:...:...:..|:|....
Human    76 GARVLLTGANAGVGEELAYHYARLGSHLVLTAHTEALLQKVVGNCRKLGAPKVFYIAADMASPEA 140

  Fly    70 TQRIWSETLQQYGKLDVLV-NNAGIIETGTIETTSLEQYDRVMNTNLRAIYHLTMLATPELVKTK 133
            .:.:....|.:.|.||.|| |:.|....|| ...|.:....:|..|..:...||..|.|.|..:|
Human   141 PESVVQFALDKLGGLDYLVLNHIGGAPAGT-RARSPQATRWLMQVNFVSYVQLTSRALPSLTDSK 204

  Fly   134 GNIVNVSSVNGIRSFPGVLAYNISKMGVDQFTRCVALELAAKGVRVNCVNPGVTVTNLHARGGMD 198
            |::|.|||:.|.........|:.:|..:|.|...:..||     .|..||..:|:..|..|....
Human   205 GSLVVVSSLLGRVPTSFSTPYSAAKFALDGFFGSLRREL-----DVQDVNVAITMCVLGLRDRAS 264

  Fly   199 AETYKKFLEHSKTTHALGRPGDVKEVAAAIAFLASDEASFSTGVSLP 245
            |....:     ..|.....||.    .||:|.:... |:.:.||..|
Human   265 AAEAVR-----GVTRVKAAPGP----KAALAVIRGG-ATRAAGVFYP 301

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31548	NP_730974.1	fabG	1..250	CDD:235975	68/242 (28%)
CG31548	NP_730974.1	NADB_Rossmann	3..253	CDD:304358	68/242 (28%)
HSD11B1L	NP_001254797.1	GVQW	3..>26	CDD:290611
		NADB_Rossmann	74..302	CDD:304358	68/242 (28%)
		PRK08251	78..302	CDD:181324	67/240 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140583
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840