DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31524 and p4ha1a

DIOPT Version :9

Sequence 1:	NP_733379.2	Gene:	CG31524 / 318781	FlyBaseID:	FBgn0051524	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	XP_009304776.1	Gene:	p4ha1a / 562774	ZFINID:	ZDB-GENE-040724-91	Length:	541	Species:	Danio rerio

Alignment Length:	548	Identity:	168/548 - (30%)
Similarity:	267/548 - (48%)	Gaps:	58/548 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 VIFFLSLSMGQIEATQPRFARSVVNMDDLLNMEDDLVSKLEGYAEKLSYKANTIRWGIQQMREQL 74
            |..||.:|:.:..:....|..|:.:|.|||..|.|||:.|:.|.:....|...::    |..|:|
Zfish     7 VCCFLLISLLKSSSAHSDFFTSIGHMTDLLFTEKDLVTSLKDYIKAEESKLEQVK----QWAEKL 67

  Fly    75 D--KSKKEQSFDLF-----NRYSFIRHMQADWLMWKQYLDKPVIRDELNYKQMDNLRM-----PQ 127
            |  .:...|..:.|     |.:..::.:..:|    ..::..|::| ::...:.||.:     |.
Zfish    68 DALTATAVQDPEGFLGHPVNAFKLMKRLNTEW----GEVEDLVLKD-MSDGFISNLTIQRQYFPN 127

  Fly   128 ELDLFDASEAIRRMQATYAMLSNDIAEGFLDGVQ----YTSKLSPIDCLAMGRHLMNQSRWTIAE 188
            :.|...|::|:.|:|.||.:.:..|:.|.|.||.    |.|.|:..||..:|:...:.:.:...|
Zfish   128 DEDQNGAAKALLRLQDTYKLDTQTISSGDLPGVNTGLPYKSTLTVEDCFELGKIAYSDADYYHTE 192

  Fly   189 QWILAGIKAQDRKGPQTEMILLRGPTKAELFRTLGKVRFERRNEEGALKAYQAALKHSPH----- 248
            .|:...:|..| :|.::.:.:      |.....|....:::...|.||:..:..|...|.
Zfish   193 LWMAQALKQLD-EGEESSVEI------ATALDYLSYSVYQQGELERALEYTKRLLTVEPEHQRAL 250

  Fly   249 -DLEIFQEYQNLKRRVLTLSPS---EPIREEPNDDIEEMELP------PCCSGRCEG----PRKL 299
             :|:.| :||..|::......|   |..:|:...|.::..||      ..|.|  ||    ||:.
Zfish   251 GNLKYF-DYQLAKQKKAEKEQSTKEESKKEQETSDGKKEYLPEKRKYEKLCRG--EGLKMTPRRQ 312

  Fly   300 NRLYCVY-NCVTAPFLRLAPIKTEILSVDPFVILLHDMVSHKEGALIRSSSKNQILPSETVN-AA 362
            ..|:|.| |....||..:.|:|.|.....|.:|..|::::.:|...|:..||.::..:...| ..
Zfish   313 KHLFCRYFNGNRHPFYTIGPVKQEDEWDRPRIIRYHEIITEQEIEKIKELSKPRLRRATISNPIT 377

  Fly   363 NEFEIAKFRTSKSVWFDSDANEATLKLTQRLGEATGLDMKHSEPFQVINYGIGGVFESHFDTSLA 427
            ...|.|.:|.|||.|..:..:....::.||:.:.|||::|.:|..||.|||:||.:|.|||....
Zfish   378 GVLETAHYRISKSAWLAAYEHPVVDRINQRIEDITGLNVKTAEELQVANYGVGGQYEPHFDFGRK 442

  Fly   428 DE-DRFVN-GYIDRLATTLFYLNDVPQGGATHFPGLNITVFPKFGTVLMWYNLHTEGMLHVRTMH 490
            || |.|.. |..:|:||.|||::||..||||.||.:...|.|..||.:.||||...|.....|.|
Zfish   443 DEPDAFKELGTGNRIATWLFYMSDVAAGGATVFPEVGAAVKPLKGTAVFWYNLFPSGEGDYSTRH 507

  Fly   491 TGCPVIVGSKWVVSKWIDDKGQEFRRPC 518
            ..|||:||:|||.:|||.::||||||||
Zfish   508 AACPVLVGNKWVSNKWIHERGQEFRRPC 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31524	NP_733379.2	P4Ha_N	31..157	CDD:285528	34/137 (25%)
		TPR_11	215..>259	CDD:290150	11/49 (22%)
		TPR_2	216..249	CDD:285020	7/38 (18%)
		P4Hc	340..507	CDD:214780	69/169 (41%)
p4ha1a	XP_009304776.1	P4Ha_N	28..157	CDD:285528	34/137 (25%)
		TPR repeat	172..207	CDD:276809	8/35 (23%)
		TPR repeat	212..242	CDD:276809	6/35 (17%)
		Fis1	218..262	CDD:304536	10/44 (23%)
		P4Hc	352..525	CDD:214780	70/172 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583436
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.750