DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31524 and CG9698

DIOPT Version :9

Sequence 1:	NP_733379.2	Gene:	CG31524 / 318781	FlyBaseID:	FBgn0051524	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	NP_651806.2	Gene:	CG9698 / 43629	FlyBaseID:	FBgn0039784	Length:	547	Species:	Drosophila melanogaster

Alignment Length:	548	Identity:	161/548 - (29%)
Similarity:	262/548 - (47%)	Gaps:	56/548 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 PVLKLLFVVIFFLSLSMGQIEATQPRFARSVVNMDDLLNMEDDLVSKLEGYAEKLSYKANTIRWG 66
            ||..:||::......|:..:|     |..|:..|..:...|..:|..::.:......|.:.::..
  Fly     4 PVFSVLFLLFHQAIPSVSGVE-----FFSSIHEMTKVFGYEQKMVLHMQKFLSDNQDKLDFLKAR 63

  Fly    67 IQQMREQLDKSKK--EQSFDL-FNRYSFIRHMQADW-----LMWKQYLDKPVIRDELNYKQMDNL 123
            :::...:.:::::  ...|:. .|:|...:.:..||     ||.....:||:.|..   |..:..
  Fly    64 LREFENERNEAREWGPSYFESPINKYLLNKRLTVDWQRVENLMATSTGEKPLTRLR---KFRNRE 125

  Fly   124 RMPQELDLFDASEAIRRMQATYAMLSNDIAEGFLDGVQYTSKLSPIDCLAMGRHLMNQSRWTIAE 188
            .||.:.:|..|.:.:.|:|..|.:.:.|:|.|.||||.|.::|:...|:.:.|..:......:|.
  Fly   126 TMPDKKELEGAIDGLLRLQYVYRLKAKDLARGILDGVDYGTQLNSEHCVDIARLALRDQHPRLAH 190

  Fly   189 QWI------LAGIKAQDRKGPQTEMILLRGPTKAELFRTLGKVRFERRNEEGALKAYQAALKHSP 247
            .|:      |.|.:.:::..||...:|::...:.|.||.|.....|       |...|:|.:...
  Fly   191 SWLIEANDRLTGGEKEEQLKPQILALLVQAKKELEDFRGLNDTYQE-------LIGIQSASEEHA 248

  Fly   248 HDLEIFQEYQNLKRRVLTLSPSEPIRE--------EPNDDIEEMELPPCCSGRCE-GPRKLNRLY 303
            .:.|.|  ...|..:.| |:.|:||.|        ||..:.:...|  .|||... .|::...|.
  Fly   249 KNYETF--LNALSEKAL-LNESKPILEHAPIPEEGEPVGEFQAYSL--TCSGHWRLTPKEQRHLR 308

  Fly   304 CVYNCVTAPFLRLAPIKTEILSVDPFVILLHDMVSHKEGALIRSSSKNQILPSETVNAANEFEIA 368
            |.|...|.|||.:||:|.|.|..||.::|.||::...|..:||..::|:::.: |:.:.||..::
  Fly   309 CGYVTETHPFLWIAPLKAEELFQDPLLVLYHDVIYQSEIDVIRKLTENRLMRA-TITSHNESVVS 372

  Fly   369 KFRTSKSVWFDSDANEATLKLTQRLGEATGLDMKHSEPFQVINYGIGGVFESH--------FDTS 425
            ..|||:..:....|::....:.||:.:.|.|:||::|..|..||||||.:..|        ||..
  Fly   373 NVRTSQFTFIPVTAHKVLSTIDQRVADMTNLNMKYAEDHQFANYGIGGHYGQHMDWFYQTTFDAG 437

  Fly   426 LADEDRFVNGYIDRLATTLFYLNDVPQGGATHFPGLNITVFPKFGTVLMWYNLHTEGMLHVRTMH 490
            |.......|    |:||.||||:||.|||.|.||.|...:.||......|:|||..|:..|||.|
  Fly   438 LVSSPEMGN----RIATVLFYLSDVAQGGGTAFPQLRTLLKPKKYAAAFWHNLHASGVGDVRTQH 498

  Fly   491 TGCPVIVGSKWVVSKWIDDKGQEFRRPC 518
            ..||:|.|||||.::||.:..|..||||
  Fly   499 GACPIIAGSKWVQNRWIRENDQSDRRPC 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31524	NP_733379.2	P4Ha_N	31..157	CDD:285528	26/133 (20%)
		TPR_11	215..>259	CDD:290150	10/43 (23%)
		TPR_2	216..249	CDD:285020	8/32 (25%)
		P4Hc	340..507	CDD:214780	65/174 (37%)
CG9698	NP_651806.2	P4Ha_N	28..159	CDD:285528	26/133 (20%)
CG9698	NP_651806.2	P4Hc	345..516	CDD:214780	66/175 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461882
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		mtm1209
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	10	9.900