DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31524 and CG4174

DIOPT Version :9

Sequence 1:	NP_733379.2	Gene:	CG31524 / 318781	FlyBaseID:	FBgn0051524	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	NP_001034031.2	Gene:	CG4174 / 40023	FlyBaseID:	FBgn0036793	Length:	473	Species:	Drosophila melanogaster

Alignment Length:	495	Identity:	121/495 - (24%)
Similarity:	217/495 - (43%)	Gaps:	70/495 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 FARSVVNMDDLLNMEDDLVSKLEGYAEKLSYKANTIRWGIQQMREQLDKSKKEQSFDLFNRYSFI 92
            ||.|..:...||.:::..|:.|:.|.:.|......||..|:| .|:|.||.|....:|...|..:
  Fly    29 FAISSESQLSLLKLKETHVNNLQSYKKVLKKHLQKIRRAIRQ-SEELLKSTKTSPRNLIYGYKVL 92

  Fly    93 RHMQADWLMWKQYLDKPVIRDELNYKQMDNLRMPQELDLFDASEAIRRMQATYAMLSNDIAEGFL 157
            ||:..||..:.:.|.|.:..:::...||...:.|..:|..::..|:.|:|..|.:.|..:.|||:
  Fly    93 RHLHNDWPQYFRLLKKDLGLEQIAVSQMLLTQQPTSVDFEESMGAMHRLQTVYNLDSYAMTEGFI 157

  Fly   158 DGVQYTSK-LSPIDCLAMGRHLMNQSRWTIAEQWI-LAGIKAQDRKGPQTEMILLRGPTKAELFR 220
            |......: .|..:||.:|...:....:..:|.|: ||.....|...|:.        .|.:|:
  Fly   158 DDKDKNIRNWSADECLMLGLMYLFLKDYNQSENWLELALYHYDDNVSPEV--------LKIKLW- 213

  Fly   221 TLGKVRFERRNEEGALKAYQAALKHSPHDLEIFQEYQNLKRRVLTLSPSEPIREEPNDDIEEMEL 285
                      |....|::...|.|...|..|. ::|.|   .:|:::|:..........::.::.
  Fly   214 ----------NYPNLLESLVEANKGLGHYFEA-KKYAN---ELLSINPNHTYMLTQLPKLKHLQS 264

  Fly   286 PPC---------------CSGRCEGPRKLNRLYCVYNCVTAPFLRLAPIKTEILSVDPFVILLHD 335
            .|.               ||.|..  ||...|.|.|...| |||:|||:|.|.||:.|::.:.:.
  Fly   265 NPAKLTKPKKVFQLQKEICSKRYR--RKSGVLVCRYVDWT-PFLKLAPLKMEELSMKPYISIFYG 326

  Fly   336 MVSHKEGALIRSSSKNQILPSETVNAANEFEIAKFRTSKSVWFDSDANEATLKLTQRLGEATGLD 400
            .:..|:..::::.|:.::...|.::.....:|....||        .::...|:.:.:...||..
  Fly   327 FLGQKDIEVLKNVSRPKLQRIEHLSGNCSCKIGNLSTS--------LHDVVRKVNELILGITGFP 383

  Fly   401 MKHSEPFQVINYGIGGVFESHFDTSLADEDRFVNGYIDRLATTLFYLNDVPQGGATHFPGLNITV 465
            :|.::..:||||||.|.:.       .:|.:     |...|....:|::..:||...||..::.|
  Fly   384 LKGNQMLEVINYGIAGNYN-------PEEPK-----IHNKANAFIFLSNAGKGGEIVFPSRHLKV 436

  Fly   466 FPKFGTVLMWYNLHTEGMLHVRTMHTGCPVIVGSKWVVSK 505
            .|:.|::|:|.||....:.|      .||::.|:.||.:|
  Fly   437 RPRKGSMLVWENLKKSLIYH------QCPILKGNMWVANK 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31524	NP_733379.2	P4Ha_N	31..157	CDD:285528	35/125 (28%)
		TPR_11	215..>259	CDD:290150	9/43 (21%)
		TPR_2	216..249	CDD:285020	5/32 (16%)
		P4Hc	340..507	CDD:214780	39/166 (23%)
CG4174	NP_001034031.2	P4Ha_N	33..157	CDD:285528	34/124 (27%)
		TPR repeat	169..197	CDD:276809	7/27 (26%)
		TPR repeat	202..245	CDD:276809	12/65 (18%)
		2OG-FeII_Oxy	<362..470	CDD:304390	34/133 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461883
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.990