DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31524 and CG18749

DIOPT Version :9

Sequence 1:	NP_733379.2	Gene:	CG31524 / 318781	FlyBaseID:	FBgn0051524	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	NP_001027154.1	Gene:	CG18749 / 3771984	FlyBaseID:	FBgn0042182	Length:	491	Species:	Drosophila melanogaster

Alignment Length:	537	Identity:	173/537 - (32%)
Similarity:	262/537 - (48%)	Gaps:	73/537 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPVLKLLFVVIFFLSL----SMGQIEATQPR-FARSVVNMDDLLNMEDDLVSKLEGYAEKLSYKA 60
            |.:||.| ..|.|||.    ..|.:.:...: :|.|.:.:..||.:||:||..|:||.:.|..|.
  Fly     1 MYILKKL-TFIGFLSACFINCQGFVNSNPKKSYAASTMELMKLLEVEDELVDNLKGYVKTLKMKF 64

  Fly    61 NTI-RWGIQQMREQLDKSKKEQSF--DLFNRYSFIRHMQADWLMWKQYLDKPVIRDELNYKQMDN 122
            |.: |..|...||.::.....:|:  :..|.:..|..:...|..|.||..| |..:.|.:  ::|
  Fly    65 NLMERSLIDMSRENMEMKSDYESYLGNPLNSFRLIHRLHTSWRKWYQYAIK-VENNALGH--IEN 126

  Fly   123 LR-----MPQELDLFDASEAIRRMQATYAMLSNDIAEGFLDGV-QYTSKLSPIDCLAMGRHLMNQ 181
            .|     :|...||..|...|..:...|.:...::|.|.|.|. |..:.|:..||||:|...:..
  Fly   127 ARLMRKMLPTSSDLQQACRGIHDLMYFYDLKPEELAAGNLAGYSQPGTGLTAYDCLALGEFGVQN 191

  Fly   182 SRWTIAEQWILAGIKAQDRKGPQTEMILLRGPTKAELFRTLGKVRFERRNEEGAL-KAYQAALKH 245
            .:..:||.|.                             .|...||:...|:..: ||:...|..
  Fly   192 QKDDLAEAWY-----------------------------NLSLTRFDNIIEKYQVHKAWALLLAK 227

  Fly   246 SPHDLEIFQEYQNLKRRVLTLSPSEPIREEPNDDIEEMELPPCCSGRCEGPRKLNRLYCVYNCVT 310
            :....|.||.::|....:  ::.:|.|..|     ..:.....|:...:.|.|  :|:|.||..|
  Fly   228 NKQLTEAFQHFENKPEGI--VASNEVIHFE-----GVLATTQNCTAVVQKPSK--KLHCRYNTST 283

  Fly   311 APFLRLAPIKTEILSVDPFVILLHDMVSHKE-GALIRSSSKNQILPSETVNAANEFEIAKFRTSK 374
            .||.|:||:|.|.|.:||::::.||::...| ..::.||....   ||:|:...    ::.||||
  Fly   284 TPFTRIAPLKMEELGLDPYMVVFHDVIYDTEIDGMLNSSDFGL---SESVSGLK----SEVRTSK 341

  Fly   375 SVWFDSDANEATLKLTQRLGEATGLDMKHSEPFQVINYGIGGVFESHFD-TSLADEDRFVNGYID 438
                ||...:|. .|.:|:.:.|||.|:.|:||.:||||:||.|..|.| ....:..|...|  |
  Fly   342 ----DSHIVDAK-TLNERVTDMTGLSMEMSDPFSLINYGLGGHFILHHDFHEYTNTTRLKQG--D 399

  Fly   439 RLATTLFYLNDVPQGGATHFPGLNITVFPKFGTVLMWYNLHTEGMLHVRTMHTGCPVIVGSKWVV 503
            |:||.||||.:|..||||.||.|||||.||.|:.:.|||||..|.::.:|:||.||||.|||:|:
  Fly   400 RIATVLFYLREVDSGGATVFPMLNITVMPKKGSAVFWYNLHNSGAVNSKTLHTACPVISGSKYVL 464

  Fly   504 SKWIDDKGQEFRRPCLR 520
            :|||::..|.|..||::
  Fly   465 TKWINELPQMFVTPCMK 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31524	NP_733379.2	P4Ha_N	31..157	CDD:285528	37/133 (28%)
		TPR_11	215..>259	CDD:290150	10/44 (23%)
		TPR_2	216..249	CDD:285020	7/33 (21%)
		P4Hc	340..507	CDD:214780	74/168 (44%)
CG18749	NP_001027154.1	P4Ha_N	35..166	CDD:285528	37/133 (28%)
CG18749	NP_001027154.1	P4Hc	314..468	CDD:214780	74/167 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461742
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		mtm1209
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	9	8.890