DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31524 and P4ha2

DIOPT Version :9

Sequence 1:	NP_733379.2	Gene:	CG31524 / 318781	FlyBaseID:	FBgn0051524	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	NP_001101745.1	Gene:	P4ha2 / 360526	RGDID:	1309673	Length:	535	Species:	Rattus norvegicus

Alignment Length:	550	Identity:	173/550 - (31%)
Similarity:	261/550 - (47%)	Gaps:	54/550 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 VIFFLSLSMGQIEATQPRFARSVVNMDDLLNMEDDLVSKLEGYAEKLSYKANTIRWGIQQMREQL 74
            |:..|....|.:...|..|..|:.:|.||:..|.|||..|:.|......|.:.|:....:|....
  Rat     5 VLVLLMSWFGVLSWVQAEFFTSIGHMTDLIYAEKDLVQSLKEYILAEEAKLSKIKSWASKMEALT 69

  Fly    75 DKSKKEQSFDL---FNRYSFIRHMQADWLMWKQYLDKPVIRD-------ELNYKQMDNLRMPQEL 129
            .||..:....|   .|.|..::.:..||    ..|...|::|       .|:.::.   ..|.:.
  Rat    70 SKSAADPEGYLAHPVNAYKLVKRLNTDW----PALGDLVLQDAAAGFVANLSVQRQ---FFPTDE 127

  Fly   130 DLFDASEAIRRMQATYAMLSNDIAEGFLDGVQYTSKLSPIDCLAMGRHLMNQSRWTIAEQWILAG 194
            |...|:.|:.|:|.||.:..:.|:.|.|.|.:|.:.||..||..|||...|:..:.....|:...
  Rat   128 DESGAARALMRLQDTYKLDPDMISRGELPGTKYQAMLSVDDCFGMGRSAYNEGDYYHTVLWMEQV 192

  Fly   195 IKAQDRKGPQTEMILLRGPTKAELFRTLGKVRFERRNEEGALKAYQAALKHSP-HD-----LEIF 253
            :|..| .|.:..:      ||:.:...|....|:..:...|::..:..|...| |:     |..|
  Rat   193 LKQLD-AGEEATV------TKSLVLDYLSYAVFQLGDLHRAVELTRRLLSLDPSHERAGGNLRYF 250

  Fly   254 QEYQNLKR-RVLT------LSPSEPIREEPNDDIEEMEL-PPCCSGRCEG----PRKLNRLYCVY 306
            :.....:| :.|:      |:..|.:.|.|.|.:.|.:: ...|.|  ||    ||:..||:|.|
  Rat   251 ERLLEEERGKSLSNQTDAGLASQENLYERPVDYLPERDVYESLCRG--EGIKMTPRRQKRLFCRY 313

  Fly   307 ---NCVTAPFLRLAPIKTEILSVDPFVILLHDMVSHKEGALIRSSSKNQILPSETVN--AANEFE 366
               |.|  |.|.:||.|.|.....|.::..:|::|.:|...|:..:|.: |...||.  ......
  Rat   314 HHGNRV--PQLLIAPFKEEDEWDSPHIVRYYDVMSDEEIERIKEIAKPK-LARATVRDPKTGVLT 375

  Fly   367 IAKFRTSKSVWFDSDANEATLKLTQRLGEATGLDMKHSEPFQVINYGIGGVFESHFDTSLADE-D 430
            :|.:|.|||.|.:.|.:....::.:|:...|||.:|.:|..||.|||:||.:|.|||.|.:|| |
  Rat   376 VASYRVSKSSWLEEDDDPVVARVNRRMQHITGLTVKTAELLQVANYGMGGQYEPHFDFSRSDERD 440

  Fly   431 RFVN-GYIDRLATTLFYLNDVPQGGATHFPGLNITVFPKFGTVLMWYNLHTEGMLHVRTMHTGCP 494
            .|.. |..:|:||.|.|::||..||||.||.|...::||.||.:.||||...|....||.|..||
  Rat   441 AFKRLGTGNRVATFLNYMSDVEAGGATVFPDLGAAIWPKKGTAVFWYNLLRSGEGDYRTRHAACP 505

  Fly   495 VIVGSKWVVSKWIDDKGQEFRRPCLRSRLD 524
            |:||.|||.:||..::||||.|||..:.:|
  Rat   506 VLVGCKWVSNKWFHERGQEFLRPCGTTEVD 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31524	NP_733379.2	P4Ha_N	31..157	CDD:285528	34/135 (25%)
		TPR_11	215..>259	CDD:290150	9/49 (18%)
		TPR_2	216..249	CDD:285020	5/33 (15%)
		P4Hc	340..507	CDD:214780	71/170 (42%)
P4ha2	NP_001101745.1	P4Ha_N	27..104	CDD:400573	20/80 (25%)
P4ha2	NP_001101745.1	P4Hc	346..519	CDD:214780	73/173 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.820