DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31524 and CG31016

DIOPT Version :9

Sequence 1:	NP_733379.2	Gene:	CG31524 / 318781	FlyBaseID:	FBgn0051524	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	NP_001263119.1	Gene:	CG31016 / 326113	FlyBaseID:	FBgn0051016	Length:	536	Species:	Drosophila melanogaster

Alignment Length:	554	Identity:	167/554 - (30%)
Similarity:	261/554 - (47%)	Gaps:	57/554 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLFVVIFFLSLS-MGQIEATQPRFARSVVNMDDLLNMEDDLVSKLEGYAEKLSYKANTIRWGIQQ 69
            :||.|.|.|.|| :.:....:..:..||....|||..:.:|:..|:.||.:|:.|...::..:::
  Fly     5 VLFAVSFILVLSWIAEGYRDRQNYVISVEEKMDLLEKDRELIIVLDSYATELNEKIIMLKRIVKE 69

  Fly    70 MREQLDKSKKEQSFDLFN---RYSFIRHMQADWLMWKQYLDKPVIRDELNYKQMDNLRMPQELDL 131
            .::.|:|:|..:...|.|   ..|.:|.|..||...::.|.|||.::::...:.....:|.|.||
  Fly    70 FKQPLEKAKNREEEYLSNPIDSLSLMRQMHEDWEKVEKLLKKPVGQEKIALVEKMREDLPVENDL 134

  Fly   132 FDASEAIRRMQATYAMLSNDIAEGFLDGVQYTSKLSPIDCLAMGRHLMNQSRWTIAEQWILAG-- 194
            .:|::|:.|:..||.:...|::.|::|||||..|:|..||..||........:.||.:|:.|.
  Fly   135 MEANQAMFRILHTYDLEPKDVSAGWIDGVQYGGKMSASDCFTMGTFSFMAGSYQIASKWLSAAKD 199

  Fly   195 -IKAQDRKGPQTEMILLRGPTKAELFRTLGKVRFERRNEEGALKAYQAALKHSPHDLEIFQEYQN 258
             :..|.||..:     :.|.|||::...|.:......|       ...|......|....:....
  Fly   200 LLVDQPRKYHE-----VMGITKADVTLLLARSLIASGN-------VSIATDMLMRDFMFGEAGSA 252

  Fly   259 LKRRVLTLSPSEPIREEPNDDIEEM-ELPPCCSGRCEGPRKLNRLYCVYNCVTAPFLRLAPIKTE 322
            |....|...|...|..|..:..|.. :|....|.|..|..|.:||:|.||.:|.|||:|||.:.|
  Fly   253 LTVHFLRNKPKPSINLESWESDESFNQLCRSSSRRQMGESKPSRLHCRYNTITTPFLKLAPFRME 317

  Fly   323 ILSVDPFVILLHDMVSHKEGALIRSSSKNQILPSETVNAANEFEIAK-------FRTSKSVW--- 377
            .||:||:||..|:::|..|...::...|      ..:..|..|.:.|       .|::...|
  Fly   318 ELSLDPYVIFYHNVLSDAEIEKLKPMGK------PFLERAKVFRVEKGSDEIDPSRSADGAWLPH 376

  Fly   378 --FDSDANEATLKLTQRLGEATGLDMKHSEPFQVINYGIGGVFESHFDTSLADEDRFVNGYI--- 437
              .|.|..|...::.:|:.:.|||:.:.....|.:.||.||.|..|:|        :.|...
  Fly   377 QNIDPDDLEVLNRIGRRIEDMTGLNTRSGSKMQFLKYGFGGHFVPHYD--------YFNSKTFSL 433

  Fly   438 ----DRLATTLFYLNDVPQGGATHFPGLNITVFPKFGTVLMWYNLHTEGM-LHVRTMHTGCPVIV 497
                ||:||.|||||:|..||||.||.||:.|..:.|:.|.|:|:..:.. ...||.|..||:|.
  Fly   434 ETVGDRIATVLFYLNNVDHGGATVFPKLNLAVPTQKGSALFWHNIDRKSYDYDTRTFHGACPLIS 498

  Fly   498 GSKWVVSKWIDDKGQEFRRPCL---RSRLDSKYL 528
            |:|.|:::||.:..|.|..|.:   |||..||.|
  Fly   499 GTKLVMTRWIYELDQMFLIPAVLPPRSRNFSKSL 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31524	NP_733379.2	P4Ha_N	31..157	CDD:285528	36/128 (28%)
		TPR_11	215..>259	CDD:290150	6/43 (14%)
		TPR_2	216..249	CDD:285020	4/32 (13%)
		P4Hc	340..507	CDD:214780	55/186 (30%)
CG31016	NP_001263119.1	P4Ha_N	31..160	CDD:285528	36/128 (28%)
CG31016	NP_001263119.1	P4Hc	333..508	CDD:214780	56/188 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461923
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		mtm1209
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	10	9.900