DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31524 and dpy-18

DIOPT Version :9

Sequence 1:	NP_733379.2	Gene:	CG31524 / 318781	FlyBaseID:	FBgn0051524	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	NP_499464.1	Gene:	dpy-18 / 176569	WormBaseID:	WBGene00001077	Length:	559	Species:	Caenorhabditis elegans

Alignment Length:	524	Identity:	152/524 - (29%)
Similarity:	242/524 - (46%)	Gaps:	59/524 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 SVVNMDDLLNMEDDLVSKLEGYAEKLSYKANTIRWGIQQMREQLDKSKKEQSFDLFNRYSFIRH- 94
            |:.:|.:||..|.::...|:.|......:       :.|:::..::..|:....:.|....|.:
Worm    21 SIADMQNLLETERNIPKILDKYIHDEEER-------LVQLKKLSEEYSKKNEISIENGLKDITNP 78

  Fly    95 MQADWLMWKQYLDKPVIRDELNYKQMDN-----------LRMPQELDLFDASEAIRRMQATYAML 148
            :.|..|:.::..|...|..::|..:..|           :|.|...||..|:..:.|:|.||.:.
Worm    79 INAFLLIKRKIFDWKEIESKMNANKAGNVVSSITDDSYGVRYPTADDLSGAAIGLLRLQDTYRLD 143

  Fly   149 SNDIAEG--FLDGVQYTSKLSPIDCLAMGRHLMNQSRWTIAEQWILAGIKAQDRKGPQTEMILLR 211
            :.|:|:|  :.|...||  .|..||..:.|...|:..:.....|:   .:||.|.|.:.|
Worm   144 TKDLADGKIYADQGNYT--FSAKDCFEIARAAYNEHDFYHTVMWM---EEAQRRLGDEVE----- 198

  Fly   212 GPT--KAELFRTLGKVRFERRNEEGALKAYQAALKHSP-HD--------LEIFQEYQNLKRRVLT 265
             ||  ..::...|....:::.|.:.|||..:...|.:| |.        .|...|.:.::|..:.
Worm   199 -PTVEVEDILEYLAFALYKQNNLKHALKLTEELYKMNPTHPRAKGNVKWYEDLLEQEGVRRSDMR 262

  Fly   266 LSPSEPIREEPNDDI----EEMELPPCCSGRCEGP---RKLNRLYCVYNCVTAPFLRLAPIKTEI 323
            .: ..||:....|.:    |.......|  |.|.|   :.::||||.|. ...|||..||||.||
Worm   263 KN-LPPIQNRRPDSVLGNTERTMYEALC--RNEVPVSQKDISRLYCYYK-RDRPFLVYAPIKVEI 323

  Fly   324 LSVDPFVILLHDMVSHKEGALIRSSSKNQILPSETV--NAANEFEIAKFRTSKSVWFDSDANEAT 386
            ...:|..:|..|::|..|.|.|:..:|.: |...||  :...:...|.:|.|||.|......:..
Worm   324 KRFNPLAVLFKDVISDDEVAAIQELAKPK-LARATVHDSVTGKLVTATYRISKSAWLKEWEGDVV 387

  Fly   387 LKLTQRLGEATGLDMKHSEPFQVINYGIGGVFESHFDTSLADEDRFVN--GYIDRLATTLFYLND 449
            ..:.:|:|..|.|:|:.:|..|:.||||||.::.|||.:..:|.:...  |..:|:||.|||::.
Worm   388 ETVNKRIGYMTNLEMETAEELQIANYGIGGHYDPHFDHAKKEESKSFESLGTGNRIATVLFYMSQ 452

  Fly   450 VPQGGATHFPGLNITVFPKFGTVLMWYNLHTEGMLHVRTMHTGCPVIVGSKWVVSKWIDDKGQEF 514
            ...||.|.|.....|:.|.....|.||||:.:|..:..|.|..|||:||.|||.:|||.:||.||
Worm   453 PSHGGGTVFTEAKSTILPTKNDALFWYNLYKQGDGNPDTRHAACPVLVGIKWVSNKWIHEKGNEF 517

  Fly   515 RRPC 518
            ||||
Worm   518 RRPC 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31524	NP_733379.2	P4Ha_N	31..157	CDD:285528	29/139 (21%)
		TPR_11	215..>259	CDD:290150	10/52 (19%)
		TPR_2	216..249	CDD:285020	7/33 (21%)
		P4Hc	340..507	CDD:214780	60/170 (35%)
dpy-18	NP_499464.1	P4Ha_N	21..152	CDD:285528	29/137 (21%)
dpy-18	NP_499464.1	P4Hc	338..511	CDD:214780	62/173 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.820