DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Erk7 and MPK19

DIOPT Version :9

Sequence 1:	NP_001188568.1	Gene:	Erk7 / 31877	FlyBaseID:	FBgn0052703	Length:	916	Species:	Drosophila melanogaster
Sequence 2:	NP_188090.2	Gene:	MPK19 / 820700	AraportID:	AT3G14720	Length:	598	Species:	Arabidopsis thaliana

Alignment Length:	623	Identity:	189/623 - (30%)
Similarity:	289/623 - (46%)	Gaps:	120/623 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 QERRIQELDQTVE----SIFDVRKRMGKGAYGIVWKATDRRTKNTVALKKVFDAFRDETDAQRTY 70
            :::.::|::...|    :.:.:.:.:|||:||:|..|.|.:|...||:||:.|.|...:||.|..
plant     6 EKKNMKEMEFFTEYGDANRYRILEVIGKGSYGVVCAAIDTQTGEKVAIKKINDVFEHVSDALRIL 70

  Fly    71 REVIFLRAFRCHPNIVRLVDIFKASNNLDF---YLVFEFMESDLHNVIKRGNVLKDVHKRFVMYQ 132
            |||..||..| ||:||.:..|....:..:|   |:|||.||||||.|||..:.|...|.:|.:||
plant    71 REVKLLRLLR-HPDIVEIKSIMLPPSKREFKDIYVVFELMESDLHQVIKANDDLTREHHQFFLYQ 134

  Fly   133 LINAIKFIHSGNVIHRDLKPSNILIDSKCRLKVADFGLARTLSSRRIYDDLEQDGMLTDYVATRW 197
            ::.|:|::|:.||.||||||.|||.::.|:|||.||||||.     .::|.......||||||||
plant   135 MLRALKYMHTANVYHRDLKPKNILANANCKLKVCDFGLARV-----SFNDTPTTVFWTDYVATRW 194

  Fly   198 YRAPEILVA-SRNYTKGIDMWGLGCILGEMIRQKPLFQGTSTVNQIEKIVTSLPNVTKLD-IASI 260
            |||||:..: ...||..||:|.:|||..|::..||||.|.|.|:|:: ::|.|....|.: ||.:
plant   195 YRAPELCGSFCSKYTPAIDIWSIGCIFAEVLTGKPLFPGKSVVHQLD-LITDLLGTPKSETIAGV 258

  Fly   261 GPSFGSVLLSRNIQRDRRYSLDEMMK-----------NCCDDGISLVKALLVLNPHNRLTAKEAI 314
                      || ::.|:| |:||.|           |.....:.|::.||..:|.:|.||.||:
plant   259 ----------RN-EKARKY-LNEMRKKNLVPFSQKFPNADPLALRLLQRLLAFDPKDRPTAAEAL 311

  Fly   315 RHPYVSRFQYASAEMDLHMDVVPPLKDHVRYDVDQYR---NSLYELIDRETSCSNRTVSNSTPSS 376
            ..||..    ..|:::......|..|  :.::.::.|   :.:.|||.||       :....|..
plant   312 ADPYFK----CLAKVEREPSCQPISK--MEFEFERRRLTKDDIRELIYRE-------ILEYHPQL 363

  Fly   377 NRDEL---------PKPV-RVTKQ---ARTTSAKQPTTSPAERKKE--PSSVEVTQSRKNIKLLG 426
            .:|.:         |..: .:.||   ....|.|.....|.:||..  |.|. |..|..|.....
plant   364 LKDYMNSEGSSFLYPSAIGHLRKQFAYLEENSGKSGPVIPPDRKHASLPRSA-VHSSAVNSNAQP 427

  Fly   427 SAHKAQSKEIN---HMESAITQVSIASAPPAAAPP-APAATAPAVPRKSGDKSVPKCQHNNAAVQ 487
            |.:.:.|:.::   .....:...|..|..|...|| .|:..    |.:..:.||   .:.|   .
plant   428 SLNASDSRRVSIEPSRNGVVPSTSAYSTKPLGPPPRVPSGK----PGRVVESSV---TYEN---D 482

  Fly   488 RELAAVAAAAAVARRKKSSWQSQAQSQGKFHTEAKAHVQTAI---QTQKDNIKDSPPRMIQESQS 549
            |.|            |:||:.::.           ::.::.:   ||...|....|..|.||.:|
plant   483 RNL------------KESSYDART-----------SYYRSTVLPPQTVSPNCYFLPNTMNQEKRS 524

  Fly   550 LTEAKAPIPKNRYSNKMCQEKK--------YKKKHHSM 579
            .||| |..||.::....|...|        |.:..|.:
plant   525 GTEA-ASQPKPQFVPTQCNSAKPAELNPNPYVQSQHKV 561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Erk7	NP_001188568.1	STKc_MAPK15-like	17..358	CDD:270841	134/363 (37%)
MPK19	NP_188090.2	STKc_TDY_MAPK	24..361	CDD:143364	137/368 (37%)
MPK19	NP_188090.2	S_TKc	25..316	CDD:214567	127/309 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0660
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D741207at2759
OrthoFinder	1	1.000	-	-		FOG0000164
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820