DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Erk7 and MPK20

DIOPT Version :9

Sequence 1:	NP_001188568.1	Gene:	Erk7 / 31877	FlyBaseID:	FBgn0052703	Length:	916	Species:	Drosophila melanogaster
Sequence 2:	NP_565989.1	Gene:	MPK20 / 818888	AraportID:	AT2G42880	Length:	606	Species:	Arabidopsis thaliana

Alignment Length:	575	Identity:	182/575 - (31%)
Similarity:	267/575 - (46%)	Gaps:	89/575 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 FDVRKRMGKGAYGIVWKATDRRTKNTVALKKVFDAFRDETDAQRTYREVIFLRAFRCHPNIVRLV 89
            |.|::.:|||:||:|..|.|..|...||:||:.|.|...:||.|..||:..||..| ||:||.:.
plant    25 FKVQEVIGKGSYGVVCSAIDTLTGEKVAIKKIHDIFEHISDAARILREIKLLRLLR-HPDIVEIK 88

  Fly    90 DIFKASNNLDF---YLVFEFMESDLHNVIKRGNVLKDVHKRFVMYQLINAIKFIHSGNVIHRDLK 151
            .|....:..:|   |:|||.||||||.|||..:.|...|.:|.:|||:.|:|:||:.||.|||||
plant    89 HIMLPPSRREFKDIYVVFELMESDLHQVIKANDDLTREHYQFFLYQLLRALKYIHTANVYHRDLK 153

  Fly   152 PSNILIDSKCRLKVADFGLARTLSSRRIYDDLEQDGMLTDYVATRWYRAPEILVA-SRNYTKGID 215
            |.|||.::.|:||:.||||||.     .::|.......|||||||||||||:..: ...||..||
plant   154 PKNILANANCKLKICDFGLARV-----AFNDTPTTIFWTDYVATRWYRAPELCGSFYSKYTPAID 213

  Fly   216 MWGLGCILGEMIRQKPLFQGTSTVNQIEKIVTSLPNVTKLDIASIG-PSFGSVLLSRNIQRDRRY 279
            :|.:|||..|::..||||.|.:.|:|:: ::|.|          :| ||..::...|| ::.|||
plant   214 IWSIGCIFAEVLMGKPLFPGKNVVHQLD-LMTDL----------LGTPSLDTISRVRN-EKARRY 266

  Fly   280 SLDEMMK-----------NCCDDGISLVKALLVLNPHNRLTAKEAIRHPYVSRFQYASAEMDLHM 333
             |..|.|           |.....:.|::.||..:|.:|.||:||:..||..    ..|:::...
plant   267 -LTSMRKKPPIPFAQKFPNADPLSLKLLERLLAFDPKDRPTAEEALADPYFK----GLAKVEREP 326

  Fly   334 DVVPPLKDHVRYDVDQY-RNSLYELIDRETSCSNRTVSNSTPSSNRDEL----------PKPV-- 385
            ...|..|....::..:. :..:.|||.||       :....|...:|.:          |..|
plant   327 SCQPITKMEFEFERRKVTKEDIRELISRE-------ILEYHPQLLKDHMNGADKASFLYPSAVDQ 384

  Fly   386 --RVTKQARTTSAKQPTTSPAERKKE--PSSVEVTQSR----KNIKLLGSAH-----KAQSKEIN 437
              |........|.|....:|.|||..  |.|..:..:.    ...||:.:.:     ..|:...|
plant   385 FRRQFAHLEENSGKTGPVAPLERKHASLPRSTVIHSTAVARGGQPKLMNNTNTLNPETTQNIPFN 449

  Fly   438 HMESAITQVSIASAPPAA--APPAPAATAPAVPRKSGDKSVPKC---QHNNAAVQRELAAVAAAA 497
            |......|.::::|.|:.  .|.||....    |.|.|...|:.   ..|....|:..|.||...
plant   450 HATIQAQQRNLSAAKPSTFMGPVAPFDNG----RISRDAYDPRSFIRSTNLPFSQQSAATVAMGK 510

  Fly   498 AVARRKKSSWQSQAQSQGKFHTEAKAHVQTAIQTQKDNIKDSPPRMIQESQSLTE 552
            ...||.....:.||:...:::..|.   ..||     ||.::|..|.:...:..|
plant   511 QQERRTTMEPEKQARQISQYNRYAP---DVAI-----NIDNNPFIMARTGMNKAE 557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Erk7	NP_001188568.1	STKc_MAPK15-like	17..358	CDD:270841	133/349 (38%)
MPK20	NP_565989.1	STKc_TDY_MAPK	24..361	CDD:143364	137/365 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0660
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D741207at2759
OrthoFinder	1	1.000	-	-		FOG0000164
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820