Protein Alignment Erk7 and MAPK11

DIOPT Version :10

• Sequence 1: NP_727335.1
• Gene: Erk7 / 31877
• FlyBaseID: FBgn0052703
• Length: 916
• Species: Drosophila melanogaster
• Sequence 2: NP_002742.3
• Gene: MAPK11 / 5600
• HGNCID: 6873
• Length: 364
• Species: Homo sapiens
• Alignment Length: 423
• Identity: 129/423 - (30%)
• Similarity: 207/423 - (48%)
• Gaps: 89/423 - (21%)

  Fly    15 QELDQTVESIFDVRKRM------GKGAYGIVWKATDRRTKNTVALKKVFDAFRDETDAQRTYREV 73
            |||::||   ::|.:|:      |.||||.|..|.|.|.:..||:||:...|:....|:|||||:
Human    11 QELNKTV---WEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYREL 72

  Fly    74 IFLRAFRCHPNIVRLVDIFKASNNL-DF---YLVFEFMESDLHNVIKRGNVLKDVHKRFVMYQLI 134
            ..|:..: |.|::.|:|:|..:.:: ||   |||...|.:||:|::| ...|.|.|.:|::|||:
Human    73 RLLKHLK-HENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVK-CQALSDEHVQFLVYQLL 135

  Fly   135 NAIKFIHSGNVIHRDLKPSNILIDSKCRLKVADFGLARTLSSRRIYDDLEQDGMLTDYVATRWYR 199
            ..:|:|||..:|||||||||:.::..|.|::.||||||           :.|..:|.||||||||
Human   136 RGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLAR-----------QADEEMTGYVATRWYR 189

  Fly   200 APEILVASRNYTKGIDMWGLGCILGEMIRQKPLFQGTSTVNQIEKIVTSLPNVTKLDIASIGPSF 264
            ||||::...:|.:.:|:|.:|||:.|:::.|.||.|:..::|:::|           :..:|...
Human   190 APEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRI-----------MEVVGTPS 243

  Fly   265 GSVLLSRNIQRDRRY----------SLDEMMKNCCDDGISLVKALLVLNPHNRLTAKEAIRHPYV 319
            ..||...:.:..|.|          .|..:.:......|.|:..:|||:...|::|.||:.|.|.
Human   244 PEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYF 308

  Fly   320 SRFQYASAEMDLHMDVVPPLKDHVRYDVDQYRNSLYELIDRETSCSNRTVSNSTPSSNRDELPKP 384
            |::.....|.:.                        |..|.......||:......:.::.|
Human   309 SQYHDPEDEPEA------------------------EPYDESVEAKERTLEEWKELTYQEVL--- 346

  Fly   385 VRVTKQARTTSAKQPTTSPAERKKEPSSVEVTQ 417
                           :..|.|..|.|.|:|:.|
Human   347 ---------------SFKPPEPPKPPGSLEIEQ 364

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Erk7	NP_727335.1	STKc_MAPK15-like	17..358	CDD:270841	116/360 (32%)
MAPK11	NP_002742.3	Protein Kinases, catalytic domain	8..348	CDD:473864	122/405 (30%)
		TXY	180..182		1/1 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	311..331		3/43 (7%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	343..364		7/38 (18%)