DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Erk7 and MAPK8

DIOPT Version :9

Sequence 1:	NP_001188568.1	Gene:	Erk7 / 31877	FlyBaseID:	FBgn0052703	Length:	916	Species:	Drosophila melanogaster
Sequence 2:	NP_001265476.1	Gene:	MAPK8 / 5599	HGNCID:	6881	Length:	427	Species:	Homo sapiens

Alignment Length:	472	Identity:	137/472 - (29%)
Similarity:	229/472 - (48%)	Gaps:	101/472 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 ESIFDVRKR------MGKGAYGIVWKATDRRTKNTVALKKVFDAFRDETDAQRTYREVIFLRAFR 80
            :|.|.|.||      :|.||.|||..|.|...:..||:||:...|:::|.|:|.|||::.::...
Human    17 DSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVN 81

  Fly    81 CHPNIVRLVDIFKASNNL----DFYLVFEFMESDLHNVIKRGNVLKDVHKR--FVMYQLINAIKF 139
             |.||:.|:::|....:|    |.|:|.|.|:::|..||:    ::..|:|  :::||::..||.
Human    82 -HKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ----MELDHERMSYLLYQMLCGIKH 141

  Fly   140 IHSGNVIHRDLKPSNILIDSKCRLKVADFGLARTLSSRRIYDDLEQDGMLTDYVATRWYRAPEIL 204
            :||..:||||||||||::.|.|.||:.|||||||..:         ..|:|.||.||:|||||::
Human   142 LHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGT---------SFMMTPYVVTRYYRAPEVI 197

  Fly   205 VASRNYTKGIDMWGLGCILGEMIRQKPLFQGTSTVNQIEKIVTSLPNVTKLDIASIGPSFGSVLL 269
            : ...|.:.:|:|.:|||:||||:...||.||..::|..|::..|.......:..:.|:..:.:
Human   198 L-GMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMKKLQPTVRTYV- 260

  Fly   270 SRNIQRDRRYSLDEMM------------KNCCDDGISLVKALLVLNPHNRLTAKEAIRHPYVSRF 322
             .|..:...||.:::.            |........|:..:||::...|::..||::|||::.:
Human   261 -ENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYINVW 324

  Fly   323 QYASAEMDLHMDVVPPLK------DHVRYDVDQYRNSLY-ELIDRETSCSNRTVSNSTPSSNRDE 380
             |..:|.:     .||.|      |...:.:::::..:| |::|.|....|..:..
Human   325 -YDPSEAE-----APPPKIPDKQLDEREHTIEEWKELIYKEVMDLEERTKNGVIRG--------- 374

  Fly   381 LPKPVRVTKQARTTSAKQPTTSPAERKKEPSSVEVTQSRKNIKLLGSAHKAQSKEINHMESAITQ 445
                             ||:         |....|        :.||.|.:.|..:|.:.|..|.
Human   375 -----------------QPS---------PLGAAV--------INGSQHPSSSSSVNDVSSMSTD 405

  Fly   446 VSIA----SAPPAAAPP 458
            .::|    |:..|||.|
Human   406 PTLASDTDSSLEAAAGP 422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Erk7	NP_001188568.1	STKc_MAPK15-like	17..358	CDD:270841	117/366 (32%)
MAPK8	NP_001265476.1	STKc_JNK	25..360	CDD:270840	112/357 (31%)
		TXY	183..185		1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	371..427		17/95 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D741207at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920