Protein Alignment Erk7 and MAPK7

DIOPT Version :9

• Sequence 1: NP_001188568.1
• Gene: Erk7 / 31877
• FlyBaseID: FBgn0052703
• Length: 916
• Species: Drosophila melanogaster
• Sequence 2: XP_006721620.1
• Gene: MAPK7 / 5598
• HGNCID: 6880
• Length: 822
• Species: Homo sapiens
• Alignment Length: 636
• Identity: 170/636 - (26%)
• Similarity: 277/636 - (43%)
• Gaps: 167/636 - (26%)

  Fly    25 FDVRKRMGKGAYGIVWKATDRRTKNTVALKKVFDAFRDETDAQRTYREVIFLRAFRCHPNIVRLV 89
            :::.:.:|.||||:|..|..|.|...||:||:.:||...|:|:||.||:..|:.|: |.||:.:.
Human    55 YEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFK-HDNIIAIK 118

  Fly    90 DIFKAS----------NNLDFYLVFEFMESDLHNVIKRGNVLKDVHKRFVMYQLINAIKFIHSGN 144
            ||.:.:          ..:..|:|.:.||||||.:|.....|...|.|:.:|||:..:|::||..
Human   119 DILRPTVPYGEFKSVPYGVPGYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQ 183

  Fly   145 VIHRDLKPSNILIDSKCRLKVADFGLARTLSSRRIYDDLEQDGMLTDYVATRWYRAPEILVASRN 209
            ||||||||||:|::..|.||:.|||:||.|.:    ...|....:|:|||||||||||::::...
Human   184 VIHRDLKPSNLLVNENCELKIGDFGMARGLCT----SPAEHQYFMTEYVATRWYRAPELMLSLHE 244

  Fly   210 YTKGIDMWGLGCILGEMIRQKPLFQGTSTVNQIEKIVTSLPNVTKLDIASIGPSFGSVLLSRNIQ 274
            ||:.||:|.:|||.|||:.::.||.|.:.|:|::.|:..|...:...|.::|           .:
Human   245 YTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVG-----------AE 298

  Fly   275 RDRRY--SL--------DEMMKNCCDDGISLVKALLVLNPHNRLTAKEAIRHPYVSRFQYASAEM 329
            |.|.|  ||        :.:........:||:..:|...|..|::|..|:|||:::::.    :.
Human   299 RVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLAKYH----DP 359

  Fly   330 DLHMDVVPPLKDHVRYDVDQYRNSLYELIDRETSCSNRTVSNSTPSSNRDELPKPVRVTKQARTT 394
            |...|..||      :|.         ..|||.....| :..:..:...|...:...:.:|.|..
Human   360 DDEPDCAPP------FDF---------AFDREALTRER-IKEAIVAEIEDFHARREGIRQQIRFQ 408

  Fly   395 SAKQPTTSPAERKKEPSSVEVTQSRKNIKLLGSAHKAQSKEINHMESAITQVSIASAPPAAAP-- 457
            .:.||..|      ||...:|                   |:....:.....::.|.|||..|
Human   409 PSLQPVAS------EPGCPDV-------------------EMPSPWAPSGDCAMESPPPAPPPCP 448

  Fly   458 ------------PAPAATAPAVPRKSGDKSVPKCQHNNAAVQRELAAVAAAAAVARRKKSSWQSQ 510
                        |.|..:.||.|:|.|           |......||:.||
Human   449 GPAPDTIDLTLQPPPPVSEPAPPKKDG-----------AISDNTKAALKAA-------------- 488

  Fly   511 AQSQGKFHTEAKAHVQTAIQTQKDNIKDSPPRMIQESQSLTEAKAPIPKNRYSNKMCQEKKYKKK 575
                             .:::.:..::|.|...::         ||.|:...:   .||::.:::
Human   489 -----------------LLKSLRSRLRDGPSAPLE---------APEPRKPVT---AQERQRERE 524

  Fly   576 HHSMSCITRDTFPSETEHRQQREERAYQRQMKRELQLKESYRRRIEAESEP 626
                            |.|::|:|||.:|:.:|  |.:|...|...|...|
Human   525 ----------------EKRRRRQERAKEREKRR--QERERKERGAGASGGP 557

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Erk7	NP_001188568.1	STKc_MAPK15-like	17..358	CDD:270841	119/352 (34%)
MAPK7	XP_006721620.1	STKc_ERK5	49..390	CDD:270842	123/370 (33%)
		S_TKc	55..353	CDD:214567	114/313 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0660
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D741207at2759
OrthoFinder	1	1.000	-	-		FOG0000164
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820