DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Erk7 and MAPK6

DIOPT Version :9

Sequence 1:	NP_001188568.1	Gene:	Erk7 / 31877	FlyBaseID:	FBgn0052703	Length:	916	Species:	Drosophila melanogaster
Sequence 2:	NP_002739.1	Gene:	MAPK6 / 5597	HGNCID:	6879	Length:	721	Species:	Homo sapiens

Alignment Length:	689	Identity:	173/689 - (25%)
Similarity:	296/689 - (42%)	Gaps:	137/689 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 FDVRKR------MGKGAYGIVWKATDRRTKNTVALKKVFDAFRDETDAQRTYREVIFLRAFRCHP 83
            ||:..|      :|.|..|:|:.|.|......||:||:  ...|....:...||:..:|... |.
Human    14 FDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKI--VLTDPQSVKHALREIKIIRRLD-HD 75

  Fly    84 NIVRLVDIFKASNNL------------DFYLVFEFMESDLHNVIKRGNVLKDVHKRFVMYQLINA 136
            |||::.:|...|.:.            ..|:|.|:||:||.||:::|.:|:: |.|..||||:..
Human    76 NIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLEE-HARLFMYQLLRG 139

  Fly   137 IKFIHSGNVIHRDLKPSNILIDSK-CRLKVADFGLARTLSSRRIYDDLEQDGMLTDYVATRWYRA 200
            :|:|||.||:||||||:|:.|::: ..||:.||||||.:...     ....|.|::.:.|:|||:
Human   140 LKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPH-----YSHKGHLSEGLVTKWYRS 199

  Fly   201 PEILVASRNYTKGIDMWGLGCILGEMIRQKPLFQGTSTVNQIEKIVTSLPNVTKLD---IASIGP 262
            |.:|::..||||.||||..|||..||:..|.||.|...:.|::.|:.|:|.|.:.|   :.|:.|
Human   200 PRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVHEEDRQELLSVIP 264

  Fly   263 SFGSVLLSRNIQRDRRYSLDEMMKNCCDDGISLVKALLVLNPHNRLTAKEAIRHPYVSRFQYASA 327
            .:     .||...:....|.:::.....:.:..::.:|..:|.:||||:||:.|||:|.:.:...
Human   265 VY-----IRNDMTEPHKPLTQLLPGISREALDFLEQILTFSPMDRLTAEEALSHPYMSIYSFPMD 324

  Fly   328 EMDLHMDVVPPLKDHVRY------DV---DQYRNSLYELIDRETSCSNRTVSNSTPSSNR---DE 380
            |         |:..|..:      |:   |:..:.:|.. :|...|  :...:..|..|.   ||
Human   325 E---------PISSHPFHIEDEVDDILLMDETHSHIYNW-ERYHDC--QFSEHDWPVHNNFDIDE 377

  Fly   381 LPKPVRVTKQARTTSAKQPTTSP-----AERKK--EPSSVEVTQSRK------------------ 420
            :....|....  .|..::....|     .:|:|  |..:.:...|.:
Human   378 VQLDPRALSD--VTDEEEVQVDPRKYLDGDREKYLEDPAFDTNYSTEPCWQYSDHHENKYCDLEC 440

  Fly   421 ----NIKLLGSAHKA----QSKEINHMESAITQVSIASAPPAAAPPAPAATAPAVPRKSGDKSVP 477
                |.|...|::..    :..|:||.......:.:::....:            ..||..|...
Human   441 SHTCNYKTRSSSYLDNLVWRESEVNHYYEPKLIIDLSNWKEQS------------KEKSDKKGKS 493

  Fly   478 KCQHNNAAVQRELAAVAAAAAVARRKKSSWQSQAQSQG-KFHTEAKAHVQTAIQTQKDNIKDSPP 541
            ||: .|..|:.::|...|:..:|.:::.      ::|| .|.:.....:|.:.|.:..::.|. .
Human   494 KCE-RNGLVKAQIALEEASQQLAGKERE------KNQGFDFDSFIAGTIQLSSQHEPTDVVDK-L 550

  Fly   542 RMIQESQSLTEAKAPIPKNRYSNKMCQEK----------KYKKKHHSM------SCITRDTFPSE 590
            ..:..|.|..|.|:.|.|:....|  |||          .|:....|.      .|...:.|...
Human   551 NDLNSSVSQLELKSLISKSVSQEK--QEKGMANLAQLEALYQSSWDSQFVSGGEDCFFINQFCEV 613

  Fly   591 TEHRQQREERAYQRQMKRELQLKESYRRRIEAESEPLKE 629
            .:..|..:|..|...:.:....||....   .|:||:::
Human   614 RKDEQVEKENTYTSYLDKFFSRKEDTEM---LETEPVED 649

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Erk7	NP_001188568.1	STKc_MAPK15-like	17..358	CDD:270841	116/363 (32%)
MAPK6	NP_002739.1	STKc_MAPK4_6	14..355	CDD:143359	116/364 (32%)
		SEG motif	189..191		0/1 (0%)
		FRIEDE motif	332..337		0/4 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	701..721
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0660
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D741207at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910