DRSC/TRiP Functional Genomics Resources

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Protein Alignment Erk7 and CDK12

DIOPT Version :10

Sequence 1:NP_727335.1 Gene:Erk7 / 31877 FlyBaseID:FBgn0052703 Length:916 Species:Drosophila melanogaster
Sequence 2:NP_057591.2 Gene:CDK12 / 51755 HGNCID:24224 Length:1490 Species:Homo sapiens


Alignment Length:665 Identity:166/665 - (24%)
Similarity:259/665 - (38%) Gaps:172/665 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 ERRIQELDQTVESI--FDVRKRMGKGAYGIVWKATDRRTKNTVALKKVFDAFRDETDAQRTYREV 73
            |||..|.|.....:  ||:...:|:|.||.|:||.|:.|...||||||......|.......||:
Human   711 ERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREI 775

  Fly    74 IFLRAFRCHPNIVRLVDI---------FKASNNLDFYLVFEFMESDLHNVIKRGNV-LKDVHKRF 128
            ..||.. .|.::|.:.:|         ||..... ||||||:|:.||..:::.|.| ..:.|.:.
Human   776 KILRQL-IHRSVVNMKEIVTDKQDALDFKKDKGA-FYLVFEYMDHDLMGLLESGLVHFSEDHIKS 838

  Fly   129 VMYQLINAIKFIHSGNVIHRDLKPSNILIDSKCRLKVADFGLARTLSSRRIYDDLEQDGMLTDYV 193
            .|.||:..:::.|..|.:|||:|.||||:::..::|:|||||||..:|       |:....|:.|
Human   839 FMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNS-------EESRPYTNKV 896

  Fly   194 ATRWYRAPEILVASRNYTKGIDMWGLGCILGEMIRQKPLFQGTSTVNQIEKIVTSL--------- 249
            .|.|||.||:|:....||..||:|..||||||:..:||:||....:.|:| :::.|         
Human   897 ITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLE-LISRLCGSPCPAVW 960

  Fly   250 PNVTKLDIASIGPSFGSVLLSRNIQRDRRYSLDEMMKNCCDDGISLVKALLVLNPHNRLTAKEAI 314
            |:|.||      |.|.::...:..:|..|.....:.....|    |:..:|.|:|..|.||::.:
Human   961 PDVIKL------PYFNTMKPKKQYRRRLREEFSFIPSAALD----LLDHMLTLDPSKRCTAEQTL 1015

  Fly   315 RHPYVSRFQYASAE-------MDLH----------------MDVVPPLKDHVR------------ 344
            :..::...:.:...       .|.|                ::..||.|...:            
Human  1016 QSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVK 1080

  Fly   345 ------------------------YDVDQYRNS-----LYELIDRETSCSNRTV-------SNST 373
                                    .|:.|..|.     |..|:..:|..|...:       ||..
Human  1081 NSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNIHSNPE 1145

  Fly   374 PSSNRDELPKPVRVTKQARTTSAKQPTTSPAERKKE--------PSSVEVT-------QSRKNI- 422
            .....:.|.:.:....:|.:......|.:|.|..||        ||:.:.|       ...:|| 
Human  1146 MQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQTTLEASSTPADMQNIL 1210

  Fly   423 -----KLLGSAHKAQSKEINHMES-----------AITQVSIASAPP--------AAAPPAPAAT 463
                 :|:.:...|.|.|.|:.:.           .:.|...|:.||        ...||.|...
Human  1211 AVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAACPPHILPPEKRPPEPPGPPPP 1275

  Fly   464 APAVPRKSGD-KSVPKCQHNNAAVQRELAAVAAAAAVARRKKSSWQSQAQSQGKFHTEAKAHVQT 527
            .|..|...|| .|.|  |..|.||...|..:.:            |.:|:..|..     .|...
Human  1276 PPPPPLVEGDLSSAP--QELNPAVTAALLQLLS------------QPEAEPPGHL-----PHEHQ 1321

  Fly   528 AIQTQKDNIKDSPPR 542
            |::..:.:.:..|.|
Human  1322 ALRPMEYSTRPRPNR 1336

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Erk7NP_727335.1 STKc_MAPK15-like 17..358 CDD:270841 115/425 (27%)
CDK12NP_057591.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..703
STKc_CDK12 719..1020 CDD:270847 105/320 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1047..1098 3/50 (6%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1161..1189 6/27 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1220..1348 29/136 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1441..1460
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1466..1490
Blue background indicates that the domain is not in the aligned region.

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